Search results for "Adhesive"
showing 10 items of 299 documents
A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices.
2020
Polydimethylsiloxane (PDMS) is commonly used in medical devices because it is non-toxic and stable against oxidative stress. Relatively high blood platelet adhesion and the need for chemical crosslinking through curing, however, limit its utility. In this research, a biostable PDMS-based polyurethane-urea bearing zwitterion sulfobetaine (PDMS-SB-UU) was synthesized for potential use in the fabrication or coating of blood-contacting devices, such as a conduits, artificial lungs, and microfluidic devices. The chemical structure and physical properties of synthesized PDMS-SB-UU were confirmed by (1)H-nuclear magnetic resonance ((1)H-NMR), X-ray diffraction (XRD), and uniaxial stress-strain cur…
Platelet-endothelial interaction in tumor angiogenesis and microcirculation
2003
Activated platelets release angiogenic growth factors and have therefore been proposed to contribute to tumor angiogenesis within a potentially prothrombotic tumor microcirculation. The aim of the study was to investigate interactions of platelets with the angiogenic microvascular endothelium of highly vascularized solid tumors during growth and in response to endothelial stimulation in comparison with normal subcutaneous tissue. Experiments were performed in the dorsal skinfold chamber preparation of C57BL/6J mice bearing the Lewis lung carcinoma (LLC-1) or methylcholanthrene-induced fibrosarcoma (BFS-1). Fluorescently labeled rolling and adherent platelets, red blood cell velocity, and ve…
Targeted SERPIN (TaSER): A dual‐action antithrombotic agent that targets platelets for SERPIN delivery
2021
BACKGROUND Occlusive thrombi are not homogeneous in composition. The core of a thrombus is rich in activated platelets and fibrin while the outer shell contains resting platelets. This core is inaccessible to plasma proteins. We produced a fusion protein (targeted SERPIN-TaSER), consisting of a function-blocking VH H against glycoprotein Ibα (GPIbα) and a thrombin-inhibiting serine protease inhibitor (SERPIN; α1-antitrypsin 355 AIAR358 ) to interfere with platelet-driven thrombin formation. AIM To evaluate the antithrombotic properties of TaSER. METHODS Besides TaSER, we generated three analogous control variants with either a wild-type antitrypsin subunit, a non-targeting control VH H, or …
Intraparenchymal Brain Hemorrhage: "Birdlime" Effect Usefulness.
2018
The authors previously reported the novel transposition techniquefor microvascular decompression (MVD) using a tissue glue-coated collagen sponge (TachoSil Tissue Sealing Sheet; CSLBehring KK, Tokyo, Japan) soaked withfibrin glue (Tisseel 2-Component Fibrin Sealant, Vapor-Heated; Baxter Healthcare,Glendale, California, USA), termed the“birdlime”technique
Analysis of the mechanical performance of hybrid (SPR/bonded) single-lap joints between CFRP panels and aluminum blanks
2013
Abstract The increasing use of innovative materials in manufacturing of modern mechanical components has led to the development of reliable joints between innovative (composite materials etc.) and traditional materials (steel, aluminum etc.). In the last few years, hybrid joints, combining the advantages of the adhesive joints and traditional mechanical joints as bolted or riveted joints, have been shown an increasing industrial interest especially in automotive and aerospace sectors. In the present paper a systematic experimental study of hybrid lap joints was carried out with the aim to detect the optimal joint configuration. Tensile tests on hybrid joints made by combining adhesive bondi…
Immediate and long-term microshear bond strength of resin-based cements to core build-up materials
2021
Background To evaluate the microshear bond strength (μ-SBS) between resin-based cements and core build-up materials after water storage. Material and methods Cylinders (1x1 mm) of conventional dual-cure resin cement (RelyX ARC, 3M ESPE), universal dual-cure resin cement (RelyX Ultimate, 3M ESPE) or self-adhesive resin cement (RelyX U200, 3M ESPE) were adhered to disks (6x2 mm) made with commercial core build-up materials (Bis-Core, Bisco or LuxaCore Z, DMG) or conventional nanocomposite resin (Filtek Z350 XT, 3M ESPE). The specimens (n=10) were submitted to μ-SBS test using a universal testing machine and fracture pattern analysis at 48 hours or after 9 months of water storage. The data wer…
The Micro-Shear bond strength of different cements to commercially pure titanium
2019
Background The most appropriate luting agent for attaching the prefabricated Ti-based insert of hybrid abutments to its ceramic component has not yet been determined. This study was done aimed at examining the micro-shear bond strength (μSBS) of different cements to commercially pure titanium (Cp Ti). Material and Methods A total of 100 milled cubes of Cp Ti was airborne-particle abraded using 250 μm aluminum oxide particles. Specimens were then divided into 5 groups (n=20) according to the type of resin cement used: (1) Panavia F.2, (2) Rely X U200, (3) Panavia SA LUTING Plus, (4) GC Fuji I, and (5) GC FujiCEM 2. After 24h storage, half of the samples were subjected to 5000 cycles of therm…
Shear bond strength of debonded ceramic restorations re-cemented by means of a cleaning and retreatment protocol
2019
Background As there is no standard method for re-cementing debonded partial ceramic restorations, the aim of this study was to evaluate the use of a non-invasive thermal protocol for cleaning and retreatment, and to study its influence on shear bond strength. Material and methods Twenty ceramic samples (IPS e.max CAD®) were bonded to composite cement cylinders and underwent a shear bond strength test (G1, n=20). A second group was created (G2, n=20), representing debonded restorations. To simulate debonding, the samples were artificially contaminated with composite cement. After debonding, these underwent a thermal protocol to remove remaining adhesive. After rebonding to the composite ceme…
Cleaning and retreatment protocol for a debonded ceramic restoration
2014
Objectives: The aim of this article is to propose a resin cement cleaning protocol for use before recementing a debonded restoration. Study Design: Ceramic samples were fabricated from IPS d.sign® and IPS e.max Press® and were treated with hydrofluoric acid etching (HF), or HF+silane (S), or HF+S+adhesive or HF+S+A+resin cement. All samples were placed in a furnace at 650º for one minute in order to attempt to pyrolyze the composite. Each step was examined under scanning electron microscopy (SEM). Results: When the cleaning protocol had been performed, it left a clean and retentive surface. Conclusions: If the restoration is placed in a furnace at 650º for one minute, the composite cement w…
A Central Nervous System Focused Treatment Program for People with Frozen Shoulder: A Feasibility Study
2022
Background: Frozen shoulder (FS) is a highly disabling pathology of poorly understood etiology, which is characterized by the presence of intense pain and progressive loss of range of motion (ROM). The aim of this study is to evaluate the feasibility and clinical impact of a CNS-focused treatment program for people with FS. Methods: 10 subjects with primary FS received a 10-week CNS-focused intervention including sensory discrimination training and graded motor imagery techniques delivered as clinic sessions (60 min) and home therapy (30 min five times per week). Measurements were taken at baseline, after a 2-week “washout” period, after treatment, and at three months follow-up.…