Search results for "Adiponectine"
showing 3 items of 3 documents
Effects of modulation of body fat in production of adiponectin in mice : consequences on hepatic metabolism of lipids
2010
Adiponectin (ApN), a 30-kDa adipokine abundantly produced by adipose tissue has been described for the first time in 1995. Early findings demonstrating serum adiponectin levels are inversely correlated with obesity initiated intense investigation of the relationship between adiponectin and all symptoms of the metabolic syndrome. Of these studies, strong evidence suggests that a weight loss induced by medication or hypocaloric diet led to increased circulating ApN levels and improvement of biochemical parameters. Thus, high levels of ApN have been correlated with an improvement of insulin sensitivity and lipid parameters reducing cardiovascular risk. However mechanisms involved in the improv…
Impact du système endocannabinoïdien sur la physiologie de l'obésité : effets de l'antagonisme des récepteurs CB1 sur le métabolisme glucido-lipidiqu…
2010
The endocannabinoïd system (ECS) is involved in many biological functions such as regulation of energy metabolism. Recently, several studies have shown an association between obesity and ECS overactivity. In addition, specific CB1R antagonists such as Rimonabant (SR141716) improved metabolic parameters in obese patients essentially through inactivation of central CB1R. However, peripheral CB1R inactivation could also contribute to the improvement of these parameters and it is this notion that we have studied. To this purpose, we tested the effects of SR141716 on obese mice in order to establish relationships between the ECS activity and lipid metabolism by looking more specifically to its r…