Search results for "Administration"

Лифляндская губернская подготовительная комиссія, 1906 г. [Лифляндская губернская подготовительная комиссия, 1906 г.]

1906

Содержание: Журналы заседаний Лифляндской губернской подготовительной комиссии (№ 1-13) по делам земского самоуправления, по учебной части, по делам церковного управления, по аграрным вопросам, о реорганизации волостного самоуправления, по судебной части. Список членов Лифл. губернской подготовительной комиссии. Перечен вопросов, внесенных на обсуждение Лифл. подготовительной комисси и другие материалы.

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

The European Regional Convergence Process, 1980-1995: Do Spatial Regimes and Spatial Dependence Matter?

2002

International audience; The authors show that spatial dependence and spatial heterogeneity matter in the estimation of the ß-convergence process among 138 European regions over the 1980 to 1995 period. Using spatial econometrics tools, the authors detect both spatial dependence and spatial heterogeneity in the form of structural instability across spatial convergence clubs. The estimation of the appropriate spatial regimes spatial error model shows that the convergence process is different across regimes. The authors also estimate a strongly significant spatial spillover effect: the average growth rate of per capita GDP of a given region is positively affected by the average growth rate of …

Les paradoxes de la Norme en matière de Responsabilité Sociale et Environnementale d'Entreprise, en France

2010

The relationship between organizational interdependency and additionality obtained from innovation ecosystem participation

2019

Abstract Despite the increased interest in innovation ecosystems, few studies have assessed the extent to which the proclaimed benefits from participating in such ecosystems also occur, and under which circumstances they do occur. Uniting the literature on organizational interdependence and social exchange theory, we assess the behavioral and output additionality obtained by innovation ecosystem participants. In doing so, we build upon a sample of 473 innovative Finnish companies, of which 312 participated in an innovation ecosystem. We find a significantly positive relationship between organizational interdependence and output additionality, and find that this relationship is mediated by b…

Decisione pubblica e responsabilità dell’amministrazione nella società dell’algoritmo

2019

In the information society, algorithms are increasingly employed to take crucial decisions that affect people’s life. By including, excluding, classifying and ranking, algorithms decide prizes and penalties, benefits and liabilities, both in the private and in the public sector: health, employment, education, finance, housing, and even criminal justice. Despite being often presented as scientific, objective and neutral, made of numbers, rules and data, this is rarely the case: in fact, algorithms adopt predictive models which involve critical judgements based on questionable opinions, beliefs, values, biases and sometimes prejudices. Algorithmic decisions are also highly resistant to legal …

La desamortización y enajenación del dominio de Sueca a finales del antiguo régimen: la presencia de Godoy como duque y señor de Sueca

2010

La concesión del ducado de Sueca a Manuel Godoy y la adquisición, mediante pública subasta del término y las pertenencias de esta villa, provocó importantes cambios en la jurisdicción y administración de la anterior posesión de la Orden de Montesa. La modificación en las condiciones de la compra, confirieron al Príncipe de la Paz los mismos privilegios de los que disfrutaba el Rey como Gran Maestre y Administrador Perpetuo, lo que acabó generando tensiones con los vecinos, terratenientes y el propio Ayuntamiento. The granting of the Duchy of Sueca to Manuel Godoy and the acquisition by auction of the territory and the belongings of this town, led to significant changes in the jurisdiction a…

Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…

2021

Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…

Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro ex…

2014

Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence…

New prospective in treatment of Parkinson's disease: Studies on permeation of ropinirole through buccal mucosa

2012

The aptitude of ropinirole to permeate the buccal tissue was tested using porcine mucosa mounted on Franz-type diffusion cells as ex vivo model. Drug permeation was also evaluated in presence of various penetration enhancers and in iontophoretic conditions. Ropinirole, widely used in treatment of motor fluctuations of Parkinson's disease, passes the buccal mucosa. Flux and permeability coefficient values suggested that the membrane does not appear a limiting step to the drug absorption. Nevertheless, an initial lag time is observed but the input rate can be modulated by permeation enhancement using limonene or by application of electric fields. Absorption improvement was accompanied by the …