Search results for "Administration"

The Effect of Tiotropium in Symptomatic Asthma Despite Low- to Medium-Dose Inhaled Corticosteroids: A Randomized Controlled Trial.

2014

BackgroundTiotropium, a once-daily long-acting anticholinergic bronchodilator, has demonstrated efficacy in patients with asthma who were symptomatic despite treatment with medium- to high-dose inhaled corticosteroids (ICS).ObjectiveThe objective of this study was to evaluate the efficacy and safety of once-daily tiotropium Respimat (5 μg or 2.5 μg), compared with placebo Respimat, as add-on therapy to low- to medium-dose ICS for adults with symptomatic asthma.MethodsA phase III, double-blind, placebo-controlled trial was conducted (NCT01316380). Adults with symptomatic asthma receiving low- to medium-dose ICS (200-400 μg budesonide or equivalent dose) and a pre-bronchodilator forced expira…

Comparison of magnetic resonance imaging of inhaled SF6 with respiratory gas analysis

2008

Magnetic resonance imaging of inhaled fluorinated inert gases ((19)F-MRI) such as sulfur hexafluoride (SF(6)) allows for analysis of ventilated air spaces. In this study, the possibility of using this technique to image lung function was assessed. For this, (19)F-MRI of inhaled SF(6) was compared with respiratory gas analysis, which is a global but reliable measure of alveolar gas fraction. Five anesthetized pigs underwent multiple-breath wash-in procedures with a gas mixture of 70% SF(6) and 30% oxygen. Two-dimensional (19)F-MRI and end-expiratory gas fraction analysis were performed after 4 to 24 inhaled breaths. Signal intensity of (19)F-MRI and end-expiratory SF(6) fraction were evaluat…

The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography.

2008

In patients with mild chronic obstructive pulmonary disease (COPD), the effect of deep inspirations (DIs) to reverse methacholine-induced bronchoconstriction is largely attenuated. In this study, we tested the hypothesis that the effectiveness of DI is reduced with increasing disease severity and that this is associated with a reduction in the ability of DI to distend the airways. Fifteen subjects [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I–II: n = 7; GOLD stage III–IV: n = 8] underwent methacholine bronchoprovocation in the absence of DI, followed by DI. The effectiveness of DI was assessed by their ability to improve inspiratory vital capacity and forced expira…

Facteurs limitant une opération de sponsoring sportif comme source d’avantage concurrentiel

2016

International audience

Pathogenicity of intrathoracically administrated Bacillus thuringiensis spores in Blatta orientalis.

2006

Abstract The ability of Bacillus thuringiensis to produce septicaemia in Periplaneta americana and Blatta orientalis has been investigated. Spores and crystals from several wild-type strains as well as spores of a B. thuringiensis crystal-deficient mutant, were first orally administrated at high doses, and no significant mortality was recorded. Intrathoracic injection of spore suspensions in P. americana revealed that this species is not very susceptible to B. thuringiensis spores. B. orientalis , by contrast, was found to be very susceptible to B. thuringiensis , with a LD 50 of about 35,000 spores, that is similar to that reported on Lepidoptera challenged with parenterally injected B. th…

Bericht über die Sitzung der Stadtverordneten Versammlung vom 29. April 1918

1918

Actionnariat salarié et création de valeur dans le cadre d'une gouvernance actionnariale et partenariale : application au contexte français

2010

The present thesis investigates the nature of relationship between the employee stock ownership and the wealth creation, in the framework of the shareholder governance and the stakeholder governance. Results indicate a non linear relation between both the employee stock ownership and the shareholder value creation taking an inversed-U form. In fact, a positive relation associates these variables for low levels of employee stock ownership. Starting from a level of 3%, the relation became negative. Results notice also a positive impact of employee stock ownership plan on the share of value allocated to employees when the percentage of employee stock ownership is significant. Under than 3% the…

Déterminants de la viabilité financière des PME

2020

To be interested in the survival of SME (small and medium-sized enterprises) is to question their ability to create rent and therefore their financial viability. Our panel study on French SMEs, between 2000 and 2018, shows that several factors play a different role in the annuity creation process. If the effectiveness of state governance seems to play a negative role, through the policies put in place, it turns out that debt plays a positive role in the wealth creation process of SME. Given the nature of the goods or service activities, the impact of suppliers and customers is different. In any case, SME in France suffer from a problem of generation renewal and transmission of knowledge whi…

Le dialogue avec les parties prenantes dans l’exercice de la RSE : caractéristiques clés pour une prise de parole collective et effective

2021

National audience; Des appels à un changement radicale des modes de production accentuent la responsabilité sociale des entreprises. Cette notion de responsabilité longtemps affiliée à la satisfaction des seuls actionnaires est aujourd’hui tournée vers d’autres acteurs tout aussi exigeants, au-delà des frontières de l’entreprise. La responsabilité sociale de l’entreprise se traduit par une pression omniprésente qui contraint les entreprises à s’adapter. Cette adaptation passe par l’intégration des préoccupations liées à l’environnement, aux questions sociales et sociétales dans la conduite de leurs activités (Gond et ali., 2011 : 121). Elle passe aussi par la prise en compte de l’ensemble d…

La mobilità volontaria nel Pubblico Impiego: margini di discrezionalità dell'Amministrazione di destinazione

2022

Il contributo, a partire da una recente pronuncia del Tribunale di Catanzaro, affronta la questione dei margini di discrezionalità della pubblica amministrazione reclutante nei procedimenti di mobilità individuale volontaria ex art. 30 d.lgs. n. 165/2001, con specifico riferimento alla fase di valutazione delle competenze professionali dei candidati. Ciò offre l’occasione per soffermarsi sulla natura dell’istituto, anche alla luce dei più recenti approdi legislativi in materia.