Search results for "Administration"

Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention.

2018

Nowadays, chemoprevention by administering natural supplements is considered an attractive strategy to reverse, suppress, or prevent the evolution of premalignant oral lesions. In particular, Barbaloin exhibits anti-proliferative, anti-inflammatory, and anti-cancer properties, and it results useful in multi-therapy with classic chemotherapeutics. Therefore, in this work, mucoadhesive buccal films, as locoregional drug delivery system able to provide a targeted and efficient therapeutic delivery of Barbaloin, are proposed. Thus, Aloin extract-loaded Eudragit (R) RL100 or Eudragit (R) RS100-based buccal films were designed in order to obtain an easily self-administrable formulation capable of…

Perspectives et bilan après 20 ans de recherche et de stratégie au bas de la pyramide, une étude bibliométrique pour le futur du management internati…

2020

Conférence en ligne; International audience; Cet article propose une analyse bibliométrique du champ des stratégies au bas de la pyramide (BoP). Différents outils sont mobilisés pour analyser et comprendre la structure du champ et, plus généralement, en identifier les différentes écoles de pensée. 364 articles citant issus de la plateforme Web of Science fournissent une base de 15 292 références. Six groupes structurant le champ émergent de nos analyses, chacun mettant en évidence une spécificité des stratégies BoP. Le mapping de ce réseau de recherches permet d'envisager de nombreuses pistes de recherche et confirme l'intérêt du BoP comme axe de recherche futur du management international.

Basic skills provision for the have‐nots: a rights hoax? Re‐examining international standards on the right to education

2011

In the present era of accelerating globalisation of the labour market and education, access to knowledge of value has become increasingly complicated. This study enquired into the rights to post‐compulsory basic education by analysing the contemporary standard‐setting instruments of the United Nations, the Council of Europe and the European Community. An analytical scheme was developed that suggested four interconnected areas of education legislation, disregard of which cumulatively maintains exclusion of educationally disadvantaged individuals from knowledge and skills with proper value in the job market. The four thematic aspects identified were rights, recognition, resources and represen…

Beer tourism and craft beer

2021

International audience

Lever Press Duration as a Measure of Frustration Motivated Response Variation in Rat Self-administration to Investigate the Effects of Frustration on…

2023

In human studies, frustration has been identified as a potential risk factor for substance use disorders. Currently, there is little research into the role of frustration in substance use disorders despite research showing that frustration tolerance in humans is associated with a lower likelihood of developing substance use problems, better outcomes in recovery, and fewer relapses. To address this need, our studies use rat self-administration models to focus on frustration-related behavior in natural reward and addiction-related behavioral procedures. First, to study frustration in operant responding, there is a need to establish a real-time objective measure and validate its use in predict…

Some effects of color incongruity in a visual Ad

2009

32; While the effects of an ad's colour on attitudes towards it have already been investigated, far less work has been done on the influence of incongruous colours. This paper examines the effects of an ad using an incongruous colour on several variables of the advertising persuasion process. Analyses of variance have been conducted for an experimental study involving 407 respondents. The results show that a colour that is incongruous with the ad or with the product advertised affects the elements of surprise, perceived provocation, attitudes towards the ad and the positive beliefs about it.

Local E-Government in Norway

2005

Efficacy of bendamustine and rituximab in splenic marginal zone lymphoma: results from the phase II BRISMA/IELSG36 study.

2018

Splenectomy in addition to immunotherapy with rituximab can provide quick and sometimes durable disease control in patients with splenic marginal zone lymphoma (SMZL). However, systemic chemotherapy is ultimately required in many cases. The BRISMA (Bendamustine-rituximab as first-line treatment of splenic marginal zone lymphoma)/IELSG (International Extranodal Lymphoma Study Group)36 trial is an open-label, single arm phase II study designed by the IELSG in cooperation with the Fondazione Italiana Linfomi and the lymphoma Study Association according to Simon's two-stage method. The primary endpoint was complete response rate. Fifty-six patients with SMZL diagnosis confirmed on central revis…

RISQUE ASSOCIE A L'UTILISATION DE LA LOI DE BENFORD POUR DETECTER DES VENTES FRAUDULEUSES DE BIENS INNOVANTS A LA MODE

2010

Benford's law has been promoted as providing the auditors with a turnkey solution for fraud detection. The purpose of this paper is to show it is not always possible to detect fraudulent sales with that law. We use sales in volume of game consoles in Japan (since 1989), in United-States, in France, in Germany and in United-Kingdom (since 2000). After reviewing briefly the literature and our study design, the chi-square test and the bias analysis were used to measure the goodness-of-fit to Benford's law. Despite the absence of actual fraud, these sale series of fashion goods are not significantly in conformity with Benford's law. Thus, for the detection of fraudulent sales in this sector, th…

Neuroethics 1995-2012. A bibliometric analysis of the guiding themes of an emerging research field

2016

International audience; In bioethics, the first decade of the twenty-first century was characterized by the emergence of interest in the ethical, legal and social aspects of neuroscience research. At the same time an ongoing extension of the topics and phenomena addressed by neuroscientists was observed alongside its rise as one of the leading disciplines in the biomedical science. One of these phenomena addressed by neuroscientists and moral psychologists was the neural processes involved in moral decision-making. Today both strands of research are often addressed under the label of neuroethics. To understand this development we recalled literature from 1995 to 2012 stored in the Mainz Neu…