Search results for "Adoptive"
showing 2 items of 182 documents
Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma
2018
Natural killer (NK) cells are innate lymphocytes with a strong antitumor ability. In tumor patients, such as multiple myeloma (MM) patients, an elevated number of NK cells after stem cell transplantation (SCT) has been reported to be correlated with a higher overall survival rate. With the aim of improving NK cell use for adoptive cell therapy, we also addressed the cytotoxicity of patient-derived, cytokine-stimulated NK cells against MM cells at specific time points: at diagnosis and before and after autologous stem cell transplantation. Remarkably, after cytokine stimulation, the patients' NK cells did not significantly differ from those of healthy donors. In a small cohort of MM patients…
"I just cursed and opened a beer" : Explaining Mobile Users' Non-Complaining Behavior Through Coping
2015
Many users experience frustrating incidents with mobile applications. However, most users do not complain about their highly negative incidents to the application providers. Such dissatisfied non-complainers cause damage to application providers: they tend to exit, switch, and spread negative word-of-mouth. Therefore, it is important to understand why mobile users do not complain about their highly negative incidents. Within information systems (IS), there are no explanations for this dilemma. To address this gap, we conducted a qualitative study. By utilizing the theory of coping as a theoretical lens, we generated a mobile-specific theory that comprises problem-focused and emotion-focused…