Search results for "African"
showing 4 items of 334 documents
Cronache dalla terra dei più felici al mondo
2023
Translation into Italian of Nobel Laureate Wole Soyinka's 2021 novel Chronicles from the Land of the Happiest People on Earth. Soyinka's Chronicles - published 48 years after his latest novel, The Interpreters - offers a fictional fresco of contemporary Nigeria, a country ridden by political and moral corruption. During the latest political campaigns, Dr. Menka finds out that some colleagues at the hospital where he works sell body parts for ritualistic reasons. Afflicted by such an unexpected discovery, he shares the news with his oldest college friend, bon viveur, star engineer, and Yoruba royal Duyole Pitan-Payne, who is about to leave the country to assume a prestigious post at the Unit…
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…
“Silence was all the boy ever got”: the silent treatment of trauma in The Nickel Boys by Colson Whitehead
2023
Gordimer's Short Novel The Late Bourgeois World. Elisabeth, a Woman in the Interregnum
1997
Focusing on a close-reading of Nobel laureate Nadine Gordimer's short novel The Late Bourgeois World, the essay investigates the history of Apartheid South African society and its racial tensions in one of its most critical moments. Gordimer's fiction and non-fiction frame the study, as well as an array of references to the major critical texts regarding the author.