Search results for "Ageing"

Mechanisms of adaptation from a multiple to a single step recovery strategy following repeated exposure to forward loss of balance in older adults

2012

When released from an initial, static, forward lean angle and instructed to recover with a single step, some older adults are able to meet the task requirements, whereas others either stumble or fall. The purpose of the present study was to use the concept of margin of stability (MoS) to investigate balance recovery responses in the anterior-posterior direction exhibited by older single steppers, multiple steppers and those that are able to adapt from multiple to single steps following exposure to repeated forward loss of balance. One hundred and fifty-one healthy, community dwelling, older adults, aged 65–80 years, participated in the study. Participants performed four trials of the balanc…

Biomarkers and Inflammatory Network in Aging: Targets for Therapies in Inflammation, advancing age and nutrition

2014

Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing?

2021

It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particular interest is a new branch of the medical science, called anti-ageing medicine since CVD are the result of cardiovascular ageing. Senescent cells (SC) accumulate in cardiovascular system contributing to the onset of typical age-related cardiovascular conditions (i.e., atherosclerosis, medial aorta degeneration, vascular remodeling, stiffness). Such conditions progress in cardiovascular pathologies (i.e., heart failure, coronary artery disease, myocardial…

Dietary Patterns and Healthy Ageing

2021

Ageing is a complex process in which multiple factors are involved that can contribute to determine whether a person will or not be affected by diseases that are more frequently observed in advanced age. The factors involved comprise genetic, environmental, behavioural, and dietary factors, which influence pathways that regulate the ageing process and the life expectancy, rendering longevity a multifaceted phenomenon. Even if a miraculous elixir or pill is not yet available, there is general agreement that nutrition has a major impact on the overall mortality and on the development of age-related chronic non-communicable diseases. Nutrition research has focused for decades on single nutrien…

Natural oxygenation of Champagne wine during ageing on lees: A metabolomics picture of hormesis

2016

International audience; The oxygenation of Champagne wine after 4 and 6 years of aging on lees in bottle was investigated by FTICR-MS and UPLC-Q-TOF-MS. Three levels of permeability were considered for the stoppers, ranging from 0.2 to 1.8 mg/L/year of oxygen transfer rate. Our results confirmed a good repeatability of ultrahigh resolution FTICR-MS, both in terms of m/z and coefficient of variation of peak intensities among biological replicates. Vintages appeared to be the most discriminated features, and metabolite annotations suggested that the oldest wines (2006) were characterized by a higher sensitivity towards oxygenation. Within each vintage, the oxygenation mechanisms appeared to b…

Le petit mangeur âgé

2019

National audience

La nutrition des personnes âgées : l'affaire de tous !

2019

National audience

STEM CELLS FOR TREATMENT OF CARDIOVASCULAR DISEASES: AN UMBRELLA REVIEW OF RANDOMIZED CONTROLLED TRIALS

2021

AIMS:\ud \ud Stem cells are a promising therapy for various medical conditions. The literature regarding their adoption for the clinical care of cardiovascular diseases (CVD) is still conflicting. Therefore, our aim is to assess the strength and credibility of the evidence on clinical outcomes and application of stem cells derived from systematic reviews and meta-analyses of intervention studies in CVD.\ud \ud METHODS and RESULTS:\ud \ud Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. For meta-analyses of RCTs, outcomes with a random-effect p-value< 0.05, the GRADE (Grading of Recommendations Ass…

Ikä, identiteetti ja ohjaava koulutus. Ikääntyvät pitkäaikaistyöttömät oppimisyhteiskunnan haasteena

2007

Piia Silvennoinen tutki väitöskirjassaan, millainen merkitys työvoimapoliittisella koulutuksella on ikääntyvien pitkäaikaistyöttömien elämässä. Koulutusten oletetaan parantavan ikääntyvien pitkäaikaistyöttömien työmarkkinakelpoisuutta ja elämänhallintaa. Silvennoinen haki vastausta siihen, miten ikääntyvät pitkäaikaistyöttömät itse suhtautuvat työvoimapoliittisiin koulutuksiin; onko niistä heille haittaa vai hyötyä. Silvennoinen kertoo, että koulutuksen hyödyllisyyttä arvioidaan sen työllistävän vaikutuksen kautta. – Mitä vähemmän koulutus työllistää, sitä enemmän myös sen muut merkitykset menettävät arvoaan ikääntyvien pitkäaikaistyöttömien elämässä, Silvennoinen toteaa. Nykyinen itseohjau…

Microstructure and rheological response of laboratory-aged SBS-modified bitumens

2019

Polymer additives are widely used to improve the performance of road bitumens including their resistance to hardening during oxidation, although their oxidative inhibitor effect has not been well documented. This study aims to investigate the effect of laboratory-simulated ageing on the microstructure, and rheological properties of Polymer Modified Bitumens (PMBs) prepared with a Styrene-Butadiene-Styrene (SBS) copolymer and sulphur as a cross-linker. The laboratory ageing was conducted through the Rolling Thin Film Oven (RTFO) and the Pressure Aging Vessel (PAV) procedures. The unaged and aged binders were characterised using the Multiple Stress Creep and Recovery (MSCR) test, Gel Permeati…