Search results for "Ageing"
showing 10 items of 609 documents
Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors
2020
Abstract Aims Leucocyte telomere length (LTL) shortening is a marker of cellular senescence and associates with increased risk of cardiovascular disease (CVD). A number of cardiovascular risk factors affect LTL, but the correlation between elevated LDL cholesterol (LDL-C) and shorter LTL is debated: in small cohorts including subjects with a clinical diagnosis of familial hypercholesterolaemia (FH). We assessed the relationship between LDL-C and LTL in subjects with genetic familial hypercholesterolaemia (HeFH) compared to those with clinically diagnosed, but not genetically confirmed FH (CD-FH), and normocholesterolaemic subjects. Methods and results LTL was measured in mononuclear cells-d…
Muscle performance, sex hormones and training in peri-menopausal and post-menopausal women
2003
Age-related deterioration in muscle performance is one of the major reasons for decreased functional capacity and disability in older people. In women, impaired muscle performance has already been observed during peri-menopause in concert with rapid and dramatic decrease in ovarian hormone production. This observation suggests that female sex steroids may have an important role among other agents in regulating muscle performance in middle-aged and older women. Previous experimental studies have shown that hormone replacement therapy (HRT) and intensive physical training have positive effects on muscle force and explosive power in healthy post-menopausal women. Hormone replacement therapy in…
Ageing and sexuality
2016
Abstract Sexuality is a dimension that concerns human health with profound implications not only in the biological and psychological aspects, but also in the social and cultural dimensions, affecting all ages of life. Sexuality in old age is still conditioned by biases, prejudices and from a stereotyped vision, which considered older people as “asexual”, in spite of several studies and surveys showing that older persons have sexual potential to express. In population surveys, a fair number of men and women aged over 60 years reported having sex at least once a month. The most influential predictor of sexual activity seems to be the physical health in older men, and the quality of the relati…
Multimorbidity and anxiety symptoms among adults aged 50 years and over from six low- and middle-income countries
2021
Currently, there are limited data on the association between multimorbidity (i.e., ≥ 2 chronic conditions) and anxiety, especially among the older population in low- and middle-income countries (LMICs). Thus, the aim of the present study was to examine the association between multimorbidity and anxiety symptoms in a large sample of adults aged ≥ 50 years from six LMICs (China, India, Ghana, Mexico, Russia, South Africa). Cross-sectional, nationally representative, community-based data from the Study on Global Ageing and Adult Health (SAGE) were analysed. A total of 11 chronic physical conditions were assessed. Anxiety symptoms referred to extreme/severe problems with worry or anxiety in the…
Sex-specific effects of natural and sexual selection on the evolution of life span and ageing in Drosophila simulans
2014
Summary Variation in the strength of age-dependent natural selection shapes differences in ageing rates across species and populations. Likewise, sexual selection can promote divergent patterns of senescence across the sexes. However, the effects of these processes on the evolution of ageing have largely been considered independently, and interactions between them are poorly understood. We use experimental evolution to investigate how natural and sexual selection affect life span and ageing in Drosophila simulans. Replicate populations were evolved under lifetime monogamy (relaxed sexual selection) or lifetime polyandry (elevated sexual selection) and at one of two temperatures, 25 °C (rela…
TRafficking profile in naive and memory B cells in young and old subjects
2012
Ikääntyvät ja työhyvinvointi : 45-64-vuotiaiden työssäjaksamiskokemuksia
2017
The aim of this study was to offer an additional point of view of the age political discourse on work endurance, initiated by Finland’s public administration in the early 2000s. The personal experiences of the staff of a multi-professional work community were exploited to find clues to occupational well-being and endurance at work. Seventeen employees aged 45—64 at the actual work community were chosen as data or material for study, i.e. to be interviewed. A phenomenological-hermeneutical approach was applied to shed light on how to create well-being at work. Personal experiences of work endurance were analyzed and interpreted along the guidelines of the stepwise method used in phenomenolog…
Diet to Reduce the Metabolic Syndrome Associated with Menopause. The Logic for Olive Oil
2020
The rates of metabolic syndrome are increasing in parallel with the increasing prevalence of obesity, primarily due to its concomitant insulin resistance. This is particularly concerning for women, as the years around menopause are accompanied by an increase in visceral obesity, a strong determinant of insulin resistance. A fall in estrogens and increase in the androgen/estrogen ratio is attributed a determining role in this process, which has been confirmed in other physiological models, such as polycystic ovary syndrome. A healthy lifestyle, with special emphasis on nutrition, has been recommended as a first-line strategy in consensuses and guidelines. A consistent body of evidence has ac…
Le petit mangeur âgé : quand l'appétit fragilise le statut nutritionnel
2018
National audience; Le vieillissement est associé à de nombreux changements physiologiques, sensoriels, psychologiques et sociologiques susceptibles d'avoir un impact délétère sur la prise alimentaire de la personne âgée. Dans le cadre de RENESSENS, 68 personnes âgées vivant en institution (66 à 100 ans ; 87,4±0.9 d'âge moyen ; 75% de femmes) ont été recrutées et suivies pendant 24 heures de façon à peser tous les aliments et toutes les boissons consommées. Les résultats ont montré que 83% des résidents ne satisfaisaient pas à leurs besoins caloriques et protidiques (43% présentaient un apport inférieur au 2/3 des apports conseillés), essentiellement à cause d'une consommation insuffisante d…