Search results for "Aggregate"
showing 10 items of 287 documents
A peptide from the staphylococcal protein Efb binds P‐selectin and inhibits the interaction of platelets with leukocytes
2022
AimsP-selectin is a key surface adhesion molecule for the interaction of platelets with leukocytes. We have shown previously that the N-terminal domain of S. aureus extracellular fibrinogen-binding protein (Efb) binds to P-selectin and interferes with platelet-leukocyte aggregate formation. Here, we aimed to identify the minimal Efb motif required for binding platelets and to characterise its ability to interfering with the formation of platelet-leukocyte aggregates.Methods and ResultsUsing a library of synthetic peptides, we mapped the platelet-binding site to a continuous 20 amino acid stretch. The peptide Efb68-87 was able to bind to resting and, to a greater extent, thrombin-stimulated …
PHEA-graft-polymethacrylate supramolecular aggregates for protein oral delivery
2013
Abstract Salmon calcitonin (sCT) is characterized by a poor oral availability. A new copolymer, β-poly(N-2-hydroxyethyl)-graft-{N-2-ethylene[2-poly(methacrylic acid sodium salt)isobutyrate]}- d , l -aspartamide (PHEA-IB-p(MANa + )), was designed for the oral administration of sCT through the formation of supramolecular aggregates (SAs) based on electrostatic interactions. Several sCT/PHEA-IB-p(MANa + ) weight ratios were characterized by turbidimetry, DLS, zeta potential, and microscopy analysis. After the incubation of sCT/PHEA-IB-p(MANa + ) complex with digestive enzymes, 10% (w/w) of loaded sCT was released in the native form. In vitro investigation was carried out to determine the copol…
Hydraulic conductivity and strength of pervious concrete for deep trench drains
2019
Abstract Pervious concrete for deep trench drains, used to stabilise slopes, must meet many requirements, namely, adequate hydraulic conductivity, adequate shear strength a few days after pouring, capacity to act as a protective filter for soils in which the drain is installed, good resistance to clogging and adequate residual hydraulic conductivity. In current engineering practice, the composition of pervious concrete for drains is improperly selected according to criteria used for no-fines concrete for road pavements. To detect more suitable and specific criteria, a laboratory investigation has been conducted aimed at identifying the composition and the properties of pervious concrete sat…
Aggregate Behavior and Microdata
2004
Abstract It is shown how one can effectively use microdata in modelling the change over time in an aggregate (e.g. mean consumption expenditure) of a large and heterogeneous population. The starting point of our aggregation analysis is a specification of explanatory variables on the micro-level. Typically, some of these explanatory variables are observable and others are unobservable. Based on certain hypotheses on the evolution over time of the joint distributions across the population of these explanatory variables we derive a decomposition of the change in the aggregate which allows a partial analysis: to isolate and to quantify the effect of a change in the observable explanatory variab…
Observations on mucus aggregates along Sicilian coasts during 1991–1992
1995
Abstract The results of some observations on gelatinous material accumulating on the sea ground and free floating in the water column along Sicilian coasts are reported. The phenomenon showed different development patterns moving from the Tyrrherian to the Jonian coast and to the Sicilian Channel. Moreover, in 1991, mucus aggregates in the Tyrrhenian sea showed a similar structure, behaviour and origin to those observed in the Adriatic sea, whereas, in 1992, only a massive growth of metaphytic threadlike algae, more or less producing gelatinous sheaths, occurred.
Computational Study on Cesium Azide Trapped in a Cyclopeptidic Tubular Structure
2008
The structures and the electronic properties of host-guest complexes formed by a cyclopeptidic tubular aggregate and the species CsN3, CS2(N-3)(2), and CS2N6 have been investigated by means of density functional theory. Taking advantage of the azide property to act as a bridge ligand between two or more metal cations, it may be possible to trap N-3(-) ions inside a confined space. This could be important for the preparation of polynitrogen molecules N-n. Results show that there are significant attractive interactions between the azide ion and the cavity walls, which make the ion stay inside the inner empty space of the cyclopeptidic aggregate. The confinement of the species CS2(N-3)(2) forc…
Protein/lipid coaggregates are formed during α-synuclein-induced disruption of lipid bilayers.
2014
Amyloid formation is associated with neurodegenerative diseases such as Parkinson's disease (PD). Significant α-synuclein (αSN) deposition in lipid-rich Lewy bodies is a hallmark of PD. Nonetheless, an unraveling of the connection between neurodegeneration and amyloid fibrils, including the molecular mechanisms behind potential amyloid-mediated toxic effects, is still missing. Interaction between amyloid aggregates and the lipid cell membrane is expected to play a key role in the disease progress. Here, we present experimental data based on hybrid analysis of two-photon-microscopy, solution small-angle X-ray scattering and circular dichroism data. Data show in real time changes in liposome …
Investigations of Chl a aggregates cross-linked by dioxane in 3-methylpentane
1997
In this work, dioxane-bound aggregates of chlorophyll a are prepared in 3-methylpentane. The properties of the aggregates are studied by using steady-state and time-resolved spectroscopies. The Q -region absorption spectrum of the y chlorophyll a-dioxane aggregate shows four clearly resolvable narrow bands with comparable intensities. The band maxima are located at 683, 689, 698 and 702 nm. The emission spectrum consists of two emission bands centred at 699 and 702 nm suggesting the presence of two types of aggregates. High degree of fluorescence polarization is detected yielding the angles between the absorption transition moments with respect to the 702 nm emission transition moment. The …
MADE – A Groupware Application to Support Real-Time Activities of Distributed and Cooperating Communities
2003
Abstract. Distributed work has increased during the last few years. Employees travelling around in different countries still need access to information and must be reachable by their colleagues. A variety of mobile devices have been utilised for this purpose. However, often, when using multiple devices, the information is available to the appropriate device only. Transferring data between the devices is not always an intuitive or easy thing to do – not while conversing at least. This paper presents a groupware application to support real-time actions of distributed communities. The problem of separate devices is addressed by combining multiple tools, media, into a platform independent aggre…
A Note on Symmetry in Job Contact Networks
2007
Since the seminal work of Granovetter (1995), the sociological literature highlighted the importance of social relationships, like friends, relatives and acquaintances, as sources of information on jobs in labor markets. Such importance is also confirmed by a number of empirical studies.3 More recently, economists have devoted considerable attention to this topic,4 so that the study of individual and aggregate economic outcomes produced by the presence of social relationships in labor markets is becoming a fruitful research area in economics.