Search results for "Aggregation"

Effect of mesoglycan on macrorheologic and microrheologic parameters

1992

Abstract Whole blood filtration, mean erythrocyte aggregation, and erythrocyte membrane fluidity were examined in 10 patients with vascular atherosclerotic disease (VAD) and in 15 VAD patients with noninsulin-dependent diabetes mellitus (NIDDM) treated with mesoglycan (100 mg orally twice a day) for 30 days. The red cell membrane transverse fluidity gradient was evaluated in the VAD subjects, and the red cell membrane protein lateral mobility was measured in the VAD subjects with NIDDM. In both groups, mesoglycan treatment was responsible for an increase in erythrocyte membrane fluidity. This finding, which reflects an improvement in the dynamic properties of red cell membrane, assumes part…

Editorial: Ischemic Stroke Prevention

2014

Time scale of protein aggregation dictated by liquid-liquid demixing

2003

The growing impact of protein aggregation pathologies, together with the current high need for extensive information on protein structures are focusing much interest on the physics underlying the nucleation and growth of protein aggregates and crystals. Sickle Cell Hemoglobin (HbS), a point-mutant form of normal human Hemoglobin (HbA), is the first recognized and best-studied case of pathologically aggregating protein. Here we reanalyze kinetic data on nucleation of deoxy-HbS aggregates by referring them to the (concentration-dependent) temperature Ts characterizing the occurrence of the phase transition of liquid-liquid demixing (LLD) of the solution. In this way, and by appropriate scalin…

BODIPY - phosphane - gold complexes : towards the elaboration of optical theranostics

2015

This work describes new anticancer agents that could be detected by optical imaging, namely optical theranostics.After a first chapter describing the context of cancer imaging and therapy, a second chapter describes a first series of BODIPY-phosphine-gold theranostics, the synthesis of which has been optimized (less steps, shortening the reaction time, scale up). Their conjugation with biomolecules (glucose, peptide) has been achieved by developing a simple and efficient method that leads to the coupling between the gold atom of the probe and the thiol of the biomolecule (modified or not), leading to a gold sulfur bound. Hence, it makes the biovectorization of the probes possible in order t…

Platelet function testing in pigs using the Multiplate® Analyzer.

2019

PLOS ONE 14(8), e0222010 (2019). doi:10.1371/journal.pone.0222010

γ‐Agregation operators and some aspects of generalized aggregation problem

2010

We explore questions related to the aggregation operators and aggregation of fuzzy sets. No preliminary knowledge of the aggregation operators theory and of the fuzzy sets theory are required, because all necessary information is given in Section 2. Later we introduce a new class of γ‐aggregation operators, which “ignore” arguments less than γ. Due to this property γ‐aggregation operators simplify the aggregation process and extend the area of possible applications. The second part of the paper is devoted to the generalized aggregation problem. We use the definition of generalized aggregation operator, introduced by A. Takaci in [7], and study the pointwise extension of a γ‐agop. First publ…

UNDERSTANDING THE RELATIONSHIP BETWEEN NORMAL FUNCTION AND ABERRANT AGGREGATION: THE CASE OF ATAXIN-3

2020

Thermodynamics of Surfactant, Block Copolymer and Their Mixtures in Water: The Role of the Isothermal Calorimetry

2009

The thermodynamics of conventional surfactants, block copolymers and their mixtures in water was described to the light of the enthalpy function. The two methodologies, i.e. the van't Hoff approach and the isothermal calorimetry, used to determine the enthalpy of micellization of pure surfactants and block copolymers were described. The van't Hoff method was critically discussed. The aqueous copolymer+surfactant mixtures were analyzed by means of the isothermal titration calorimetry and the enthalpy of transfer of the copolymer from the water to the aqueous surfactant solutions. Thermodynamic models were presented to show the procedure to extract straightforward molecular insights from the …

Formulation and test of an ice aggregation scheme for two-moment bulk microphysics schemes

2013

A simple formulation of aggregation for 2-moment bulk microphysical models is de-rived. The solution involves the evaluation of a double integral of the collection kernelweighted with the crystal size (or mass) distribution. This quantity is to be inserted intothe differential equation for the crystal number concentration which has classical form. The double integrals are evaluated numerically for log-normal size distributions overa large range of geometric mean masses. A polynomial fit of the results is given thatyields good accuracy. Various tests of the new parameterization are described: aggre-gation as stand-alone process, in a box-model, and in 2-D simulations of a cirrostratuscloud. …

The impact of gender and age at onset on the familial aggregation of schizophrenia.

1993

Some recent family studies have shown that the familial risk for schizophrenia is higher in female than in male schizophrenics. It is debated whether the risks for the other disorders, such as schizotypal personality disorder or affective disorders in families of schizophrenics are similarly influenced by the proband's gender. Also, the reason for the effect of proband's gender on the recurrence risk for schizophrenia has not been clarified. This family study (159 probands, 589 first degree relatives) confirms that schizophrenia, but also schizophrenia spectrum disorders were more frequent in families of female compared with male schizophrenics. Neither age at onset in probands nor the inte…