Search results for "Agoni"

showing 10 items of 2493 documents

El consentimiento en el proceso penal : ¿un oxímoron?

2021

We are involved in a moment of deep changes in Criminal Procedure due, among other reasons, to the permanent expansion of Criminal Law. Legislative modifications have taken place one another over the world and they have led to a functional reformulation of the role played by the protagonists of Criminal Procedure. These changes have not finished yet and the future is still to come, but new elements are already emerging: the consent of the actors of the process and of the victims and the reinforcement of the principle of opportunity are undoubtedly some of them. Probation, diversion, compliance, criminal mediation are institutions that stand on the principle of consent for procedural purpose…

:CIENCIAS JURÍDICAS [UNESCO]principle of oppotunity 208 235among other reasonscriminal mediation are institutions that stand on the principle of consent for procedural purposes and show this new scenario that is emerging. Speaking about consent in criminal proceedings seems to be no longer an oxymoron Consentimientoto the permanent expansion of Criminal Law. Legislative modifications have taken place one another over the world and they have led to a functional reformulation of the role played by the protagonists of Criminal Procedure. These changes have not finished yet and the future is still to comecompliance2070-8157 22082 Revista Boliviana de Derecho 565487 2021 31 7730057 El consentimiento en el proceso penal ¿un oxímoron? Barona VilarConsentbut new elements are already emerging: the consent of the actors of the process and of the victims and the reinforcement of the principle of opportunity are undoubtedly some of them. ProbationUNESCO::CIENCIAS JURÍDICASdiversionprincipio de oportunidadSilvia We are involved in a moment of deep changes in Criminal Procedure duethe consent of the actors of the process and of the victims and the reinforcement of the principle of opportunity are undoubtedly some of them. Probation [but new elements are already emerging]
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Influencia de la diabetes experimental sobre la reactividad de las arterias carótida y renal de conejo al péptido atrial natriurético : mecanismos im…

2013

La diabetes está asociada a una mayor prevalencia de hipertensión, ictus, enfermedades cardiovasculares y nefropatía. El péptido atrial natriurético (ANP) juega un papel importante en la fisiopatología cardiovascular y podría tener acciones protectoras cardiovasculares y nefrovasculares en pacientes diabéticos. En este trabajo hemos estudiado las modificaciones producidas por la diabetes en los mecanismos que regulan la respuesta de las arterias carótida y renal de conejo al ANP. La concentración plasmática de ANP en conejos diabéticos fue mayor que en conejos control. ARTERIA CARÓTIDA. El ANP indujo una relajación de la arteria carótida, que fue menor en conejo diabético que en conejo cont…

:CIENCIAS MÉDICAS ::Patología::Patología cardiovascular [UNESCO]:CIENCIAS MÉDICAS ::Patología::Patología experimental [UNESCO]diabetesUNESCO::CIENCIAS MÉDICAS ::Patología::Patología experimentalUNESCO::CIENCIAS MÉDICAS ::Patología::Patología cardiovascularcanales de potasioarteria carótidapéptido atrial natriuréticocardiovascular systemarteria renalprostanoidesendoteliohormones hormone substitutes and hormone antagonistscirculatory and respiratory physiology
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Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the a…

2015

Chronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of his…

:Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Organogenesis::Neurogenesis [Medical Subject Headings]CB1 receptorTubulina (proteína)Cannabinoid receptorCarbamatosEtanol:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Nuclear Proteins::Histones [Medical Subject Headings]Ventrículos lateralesSacarosaNeuronasSubgranular zone0302 clinical medicine:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors G-Protein-Coupled::Receptors Cannabinoid::Receptor Cannabinoid CB1 [Medical Subject Headings]Histonas:Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids Acyclic::Carbamates [Medical Subject Headings]Receptor cannabinoide CB1Cannabinoid receptor type 2:Organisms::Eukaryota::Animals [Medical Subject Headings]:Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation [Medical Subject Headings]:Anatomy::Cells::Stem Cells::Neural Stem Cells [Medical Subject Headings]:Anatomy::Nervous System::Neurons [Medical Subject Headings]health care economics and organizations:Anatomy::Nervous System::Central Nervous System::Brain::Cerebral Ventricles::Lateral Ventricles [Medical Subject Headings]Original Research:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyuridine::Bromodeoxyuridine [Medical Subject Headings]0303 health sciencesAlcoholismoalcoholConsumo de alcoholNeurogenesis:Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markers [Medical Subject Headings]:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Cannabinoid Receptor Modulators::Cannabinoid Receptor Agonists [Medical Subject Headings]Benzamidas:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors G-Protein-Coupled::Receptors Cannabinoid::Receptor Cannabinoid CB2 [Medical Subject Headings]Endocannabinoid system3. Good healthbromodesoxiuridinaneurogenesisEndocannabinoidesmedicine.anatomical_structure:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases [Medical Subject Headings]ACEADietaAlcoholFosforilaciónAgonistmedicine.medical_specialtyHidrolasasmedicine.drug_classNeurogenesiseducation:Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism [Medical Subject Headings]Subventricular zoneBiology:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Hippocampus::Dentate Gyrus [Medical Subject Headings]lcsh:RC321-57103 medical and health sciencesCellular and Molecular NeuroscienceRatasInternal medicine:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Nerve Tissue Proteins::Tubulin [Medical Subject Headings]JWH133medicineGiro dentadolcsh:Neurosciences. Biological psychiatry. Neuropsychiatry030304 developmental biologyCélulas madre nerviosas:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids [Medical Subject Headings]Dentate gyrusmarcadores genéticosCB2 receptor:Chemicals and Drugs::Carbohydrates::Polysaccharides::Oligosaccharides::Disaccharides::Sucrose [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Hypothalamus [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol [Medical Subject Headings]Endocrinology:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings]nervous system:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings]:Chemicals and Drugs::Organic Chemicals::Amides::Benzamides [Medical Subject Headings]030217 neurology & neurosurgeryHipotálamoNeuroscience
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Cardiovascular and Renal Outcomes of Renin–Angiotensin System Blockade in Adult Patients with Diabetes Mellitus: A Systematic Review with Network Met…

2016

Background Medications aimed at inhibiting the renin–angiotensin system (RAS) have been used extensively for preventing cardiovascular and renal complications in patients with diabetes, but data that compare their clinical effectiveness are limited. We aimed to compare the effects of classes of RAS blockers on cardiovascular and renal outcomes in adults with diabetes. Methods and Findings Eligible trials were identified by electronic searches in PubMed/MEDLINE and the Cochrane Database of Systematic Reviews (1 January 2004 to 17 July 2014). Interventions of interest were angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and direct renin (DR) inhibitors. T…

ACE inhibitorsMyocardial InfarctionAngiotensin-Converting Enzyme Inhibitors030204 cardiovascular system & hematologyACE inhibitor therapyBiochemistryRenin-Angiotensin SystemAnginachemistry.chemical_compoundEndocrinologyMathematical and Statistical Techniques0302 clinical medicineReninMedicine and Health SciencesSecondary Prevention030212 general & internal medicineMyocardial infarctionDiureticsStrokePharmaceuticsRDrugsEnzyme inhibitorsCardiovascular therapyGeneral Medicine3. Good healthHospitalizationStrokeNephrologyCardiovascular DiseasesPhysical SciencesCardiologyMedicineDrug therapyStatistics (Mathematics)Research Articlemedicine.drugAdultmedicine.medical_specialtyEndocrine DisordersCardiologyResearch and Analysis MethodsAngina PectorisDiabetes ComplicationsAngiotensin Receptor Antagonists03 medical and health sciencesDiabetes mellitusInternal medicineRenal DiseasesDiabetes MellitusmedicineHumansStatistical MethodsRenal Insufficiency ChronicPharmacologyHeart FailureCreatinineBiology and life sciencesbusiness.industryOdds ratiomedicine.diseasechemistryMetabolic DisordersHeart failuresistema cardiovascularACE inhibitorEnzymologyKidney Failure ChronicbusinessMathematicsMeta-AnalysisPLOS Medicine
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Central functional response to the novel peptide cannabinoid, hemopressin.

2013

Hemopressin is the first peptide ligand to be described for the CB₁ cannabinoid receptor. Hemopressin acts as an inverse agonist in vivo and can cross the blood-brain barrier to both inhibit appetite and induce antinociception. Despite being highly effective, synthetic CB₁ inverse agonists are limited therapeutically due to unwanted, over dampening of central reward pathways. However, hemopressin appears to have its effect on appetite by affecting satiety rather than reward, suggesting an alternative mode of action which might avoid adverse side effects. Here, to resolve the neuronal circuitry mediating hemopressin's actions, we have combined blood-oxygen-level-dependent, pharmacological-ch…

AM251MaleCannabinoid receptorHypothalamus MiddleNerve Tissue ProteinsNucleus accumbensSatiety ResponseRats Sprague-DawleyCellular and Molecular Neurosciencechemistry.chemical_compoundHemoglobinsMiceRandom AllocationPiperidinesReceptor Cannabinoid CB1Appetite DepressantsmedicineInverse agonistAnimalsPeriaqueductal GrayPharmacologyMice KnockoutNeuronsBehavior AnimalCannabinoidsHemopressinPeptide FragmentsRatsVentral tegmental areamedicine.anatomical_structurechemistryPyrazolesRaphe NucleiBrain stimulation rewardRaphe nucleiPsychologyNeuroscienceInjections Intraperitonealmedicine.drugNeuropharmacology
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Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice

2010

Background  Cannabinoid type 1 (CB1) receptors are involved in the regulation of gastrointestinal (GI) motility and secretion. Our aim was to characterize the roles of the CB1 receptor on GI motility and secretion in vitro and in vivo by using different classes of CB1 receptor antagonists. Methods  Immunohistochemistry was used to examine the localization of CB1 receptor in the mouse ileum and colon. Organ bath experiments on mouse ileum and in vivo motility testing comprising upper GI transit, colonic expulsion, and whole gut transit were performed to characterize the effects of the inverse agonist/antagonist AM251 and the neutral antagonist AM4113. As a marker of secretory function we mea…

AM251medicine.medical_specialtyCannabinoid receptorEndocrine and Autonomic SystemsPhysiologymedicine.medical_treatmentdigestive oral and skin physiologyGastroenterologyMotilityBiologyEndocrinologyRimonabantIn vivoInternal medicinemedicineInverse agonistCannabinoidReceptormedicine.drugNeurogastroenterology & Motility
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Acetaldehyde operant self-administration in rats: focus on D2-receptor activation.

2013

Acetaldehyde (ACD), ethanol first metabolite, is rewarding in rodents and humans; it induces “place preference”, is self-administer directly in the VTA, orally in an operant/conflict paradigm and increases DA neurons’ firing. This research aims at investigating DA2-receptor role in the reinstatement of acetaldehyde operant-drinking behaviour, following induction, maintenance and abstinence in the rat. Male Wistar rats are trained to orally self-administer ACD solution (3.2% v/v) or water, in an operant chamber under a FR1. Afterwards animals undergo cyclic periods of deprivation and relapse to ACD. The effect ofD2-receptor activation by quinpirole (0.03mg/kg,i.p.) on operant ACD self-admini…

Acetaldehyde self-administration D2 agonistSettore BIO/14 - Farmacologia
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Effect of short-chain alcohols on surfactant-mediated reversed-phase liquid chromatographic systems.

2010

The behaviour of β-blockers in a reversed-phase liquid chromatographic (RPLC) column with mobile phases containing a short-chain alcohol (methanol, ethanol or 1-propanol), with and without the surfactant sodium dodecyl sulphate (SDS), was explored. Two surfactant-mediated RPLC modes were studied, where the mobile phases contained either micelles or only surfactant monomers at high concentration. Acetonitrile was also considered for comparison purposes. A correlation was found between the effects of the organic solvent on micelle formation (monitored by the drop weight procedure) and on the nature of the chromatographic system (as revealed by the retention, elution strength and peak shape of…

AcetonitrilesAdrenergic beta-Antagonists1-PropanolBiochemistryMicelleAnalytical ChemistryHydrophobic effectchemistry.chemical_compoundSurface-Active AgentsPulmonary surfactantPhase (matter)AcetonitrileMicellesChromatography Reverse-PhaseChromatographyEthanolElutionChemistryMethanolOrganic ChemistryCationic polymerizationSodium Dodecyl SulfateGeneral MedicineReversed-phase chromatographyAlcoholsData Interpretation StatisticalJournal of chromatography. A
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Submicellar and micellar reversed-phase liquid chromatographic modes applied to the separation of beta-blockers.

2009

The behaviour of a reversed-phase liquid chromatographic (RPLC) system (i.e. elution order, resolution and analysis time), used in the analysis of β-blockers with acetonitrile-water mobile phases, changes drastically upon addition of an anionic surfactant (sodium dodecyl sulphate, SDS). Surfactant monomers cover the alkyl-bonded phase in different extent depending on the concentration of both modifiers, in the ranges 1 × 10-3-0.15 M SDS and 5-50% acetonitrile. Meanwhile, the surfactant is dissolved in the mobile phase as free monomers, associated in small clusters or forming micelles. Four characteristic RPLC modes are yielded, with transition regions between them: hydro-organic, micellar, …

AcetonitrilesAdrenergic beta-AntagonistsAnalytical chemistryBiochemistryMicelleSensitivity and SpecificityAnalytical Chemistrychemistry.chemical_compoundPulmonary surfactantSurfactant-mediated chromatographic systemsPhase (matter)Sodium dodecyl sulphateSelectivityAcetonitrileAcetonitrileMicellesChromatographyElutionChemistryOrganic ChemistryCationic polymerizationAnalysis timeSodium Dodecyl SulfateGeneral MedicineReversed-phase chromatographyDirect transfer mechanismModels ChemicalCritical micelle concentrationSolventsβ-BlockersAlgorithmsChromatography LiquidJournal of chromatography. A
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Performance of different C18 columns in reversed-phase liquid chromatography with hydro-organic and micellar-organic mobile phases

2014

Column selection in reversed-phase liquid chromatography (RPLC) can become a challenge if the target compounds interact with the silica-based packing. One of such interactions is the attraction of cationic solutes to the free silanols in silica-based columns, which is a slow sorption-desorption interaction process that gives rise to tailed and broad peaks. The effect of silanols is minimised by the addition of a competing agent in the mobile phase, such as the anionic surfactant sodium dodecyl sulphate (SDS). In micellar-organic RPLC, the adsorption of an approximately fixed amount of SDS monomers gives rise to a stable modified stationary phase, with properties remarkably different from th…

AcetonitrilesAdrenergic beta-AntagonistsBiochemistryAnalytical ChemistrySurface-Active AgentsAdsorptionPulmonary surfactantPhenolsPhase (matter)Sodium dodecyl sulphateAcetonitrileMicellesChromatography Reverse-PhaseChromatographyElutionChemistryOrganic ChemistryCationic polymerizationC18 columnsSodium Dodecyl SulfateWaterGeneral MedicineReversed-phase chromatographySilanesMicellar liquid chromatographyβ-BlockersAdsorptionSelectivityMicellar liquid chromatography
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