Search results for "Agoni"

Day and Night Control of COPD and Role of Pharmacotherapy: A Review

2020

Abstract The topic of 24-hour management of COPD is related to day-to-night symptoms management, specific follow-up and patients’ adherence to therapy. COPD symptoms strongly vary during day and night, being worse in the night and early morning. This variability is not always adequately considered in the trials. Night-time symptoms are predictive of higher mortality and more frequent exacerbations; therefore, they should be a target of therapy. During night-time, in COPD patients the supine position is responsible for a different thoracic physiology; moreover, during some sleep phases the vagal stimulation determines increased bronchial secretions, increased blood flow in the bronchial circ…

The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms.

2015

Objectives:\ud The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.\ud \ud Methods:\ud Pharmacological manipulation of the activity of CRF receptors, CRF1 and CRF2, was performed in 3T3L1 white pre-adipocytes and T37i brown pre-adipocytes during in vitro differentiation. The expression of genes of the CRF/urocortin system and of markers of white and brown adipocytes was evaluated along with mitochondrial biogenesis and cellular oxygen consumption. Metabolic evaluation of corticosterone-deficient or supplemented Crhr1-null (Crhr1−/−) mice and their wild-type controls was performed alo…

Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neurob…

2012

The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mecha- nisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivation as an attractive perspective for neuroblastoma treat- ment. In addition to its role in tumorigenesis, MYCN sensitizes untransformed and cancer cells to apoptosis. This is associated to a fine modulation of the MDM2-p53 pathway Indeed MYCN induces p53 and MDM2 transcription, and, by evoking a DNA damage response (DDR), it stabilizes p53 and its proapoptotic kinase Homeodomain Interacting Prote…

NMDA receptor antagonists and pain relief: A meta-analysis of experimental trials

2019

ObjectiveWe conducted a meta-analysis of controlled trials that used experimental models of acute pain and hyperalgesia to examine the analgesic effects of NMDA receptor (NMDAR) antagonists.MethodsSix major databases were systematically searched (to March 2018) for studies using human evoked pain models to compare NMDAR antagonists with no-intervention controls. Pain outcome data were analyzed with random-effects meta-analysis.ResultsSearches identified 70 eligible trials (n = 1,069). Meta-analysis found that low-dose ketamine (<1 mg/kg) produced a decrease in hyperalgesic area (standardized mean difference 0.54, 95% confidence interval [CI] 0.34, 0.74, p < 0.001) and a 1.2-point decr…

Pharmacogenomics: A Step forward Precision Medicine in Childhood Asthma.

2022

Personalized medicine, an approach to care in which individual characteristics are used for targeting interventions and maximizing health outcomes, is rapidly becoming a reality for many diseases. Childhood asthma is a heterogeneous disease and many children have uncontrolled symptoms. Therefore, an individualized approach is needed for improving asthma outcomes in children. The rapidly evolving fields of genomics and pharmacogenomics may provide a way to achieve asthma control and reduce future risks in children with asthma. In particular, pharmacogenomics can provide tools for identifying novel molecular mechanisms and biomarkers to guide treatment. Emergent high-throughput technologies, …

Humanization of Physical Education in Early School Educationen

2019

The article describes the possibilities offered by organising humanist-oriented physical education classes at the first stage of education. As part of physical education, which includes the process of physical upbringing and physical training, a teacher has the opportunity to influence pupils not only in terms of their physical fitness and health prevention, but also in terms of socially desirable values. In the research part of the paper, an assessment of the state of humanisation of physical education in early school education was undertaken, adopting the pupils' behaviour as a subject of research, which was in turn an indicator of the manifestation of values resulting from the assumption…

The martial art of judo as educational contents for children who living in an open society

2014

Los premios literarios y el canon literario. El caso Protagonista Jove

2021

El objetivo del estudio que presentamos en este capítulo1 es actualizar una de las líneas del trabajo realizado por la doctora Blanca Ana Roig Rechou (2013): los premios literarios en la literatura infantil y juvenil. Ahora, apor tamos los datos del Premi de Literatura «Protagonista Jove» que convoca el Consell Català del Llibre Infantil i Juvenil (ClijCAT) desde el curso 1996- 1997, dirigido a lectores de 12 a 16 años. Concretamente, presentamos los datos resultantes del análisis cuantitativo de las 23 ediciones del premio que tuvieron lugar entre 1996 y 2019. PID2019-10587RB-I00

Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated ad…

2002

A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three GABA/BDZ R agonists (DZ) alprazolam (ALP) and zolpidem (ZOLP)), on different stress-related behavioural patterns, in non-handled (NH), short-lasting handled (SLH) and long-lasting handled (LLH) adult male rats exposed to forced swim test (FST), acoustic startle reflex (ASR) and Vogel test (VT). The effects on motor activity were evaluated in the open field and in the Skinner box…

Le associazioni tra microrganismi

2008

Le associazioni tra microrganismi rivestono un ruolo centrale nell’ecologia microbica, la branca della microbiologia che studia le interelazioni tra micror- ganismi, dei microrganismi con organismi eucarioti (protozoi, nematodi, piante e animali) e con le componenti abiotiche dell’ambiente. I microrgani- smi possono anche partecipare ad associazioni genetiche, quali coniugazione, trasduzione e trasformazione, in particolare i batteri sono frequentemente implicati in una serie di interazioni non genetiche con altri microrganismi oggetto di questo capitolo. Infatti, in qualsiasi habitat i microrganismi viva- no e si moltiplichino essi devono interagire con altri micro- e macrorganismi facendo…