Search results for "Agoni"

A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype.

1996

1. The selectivity of action of boldine and the related aporphine alkaloids, predicentrine (9-O-methylboldine) and glaucine (2,9-O-dimethylboldine) and alpha 1-adrenoceptor subtypes was studied by examining [3H]-prazosin competition binding in rat cerebral cortex. WB 4101 and benoxathian were used as selective alpha 1A-adrenoceptor antagonists. 2. In the competition experiments [3H]-prazosin (0.2 nM) binding was inhibited by WB 4101 and benoxathian. The inhibition curves displayed shallow slopes which could be subdivided into high and low affinity components (pKi = 9.92 and 8.29 for WB 4101, 9.35 and 7.94 for benoxathian). The two antagonists recognized approximately 37% of the sites with h…

Primary Cell Culture of Fresh Water Hyriopsis cumingii Mantle/Pearl Sac Tissues and Its Effect on Calcium Carbonate Mineralization

2014

Primary cell cultures of the fresh water Hyriopsis cumingii mantle and pearl sac tissues were produced in this study, and the influence of the tissue, cells, and secreted protein on calcium carbonate crystal nucleation and growth was studied. The study contributes to a further understanding of the influence of organic matrices on CaCO3 crystal formation. This research started from the protein level to the tissue/cell level, which is crucial for understanding the inorganic deposition process. The new data also add relevant theoretical approaches to an overall understanding of biomineralization processes. In the experimental groups with mantle or pearl sac tissue, the growth patterns of arago…

Micro-Raman spectroscopy of pigments contained in different calcium carbonate polymorphs from freshwater cultured pearls

2008

The metastable calcium carbonate polymorph vaterite has recently been found to occur commonly in freshwater cultured pearls from Japan and China. Organic pigment molecules in these vaterite regions of freshwater cultured pearls were analysed by resonance and near-resonance micro-Raman spectroscopy, in single spectra and in mapping modes and are compared with their aragonitic counterparts. Four different excitation wavelengths (487.9, 514.5, 532.2 and 632.8 nm) were used, resulting in differential increase of resolution for the pigments. Although vaterite areas were always lightly coloured (light yellow, light brown or white), ten different pigments were identified and a single colour is for…

A 45-year sub-annual reconstruction of seawater temperature in the Bay of Brest, France, using the shell oxygen isotope composition of the bivalve Gl…

2020

A reconstruction of sea surface temperature (SST) spanning 45 years (1966–2011) was developed from δ18O obtained from the aragonitic shells of Glycymeris glycymeris, collected from the Bay of Brest, France. Bivalve sampling was undertaken monthly between 2014 and 2015 using a dredge. In total, 401 live specimens and 243 articulated paired valves from dead specimens were collected, of which 24 individuals were used to reconstruct SST. Temperatures determined using the palaeotemperature equation of Royer et al. compared well with observed SST during the growing season between 1998 and 2010 (Pearson’s correlation: p = 0.002, r = 0.760). Furthermore, a significant negative correlation was foun…

Implications for paleomobility studies of the effects of quaternary volcanism on bioavailable strontium: a test case in North Patagonia (Argentina)

2020

Strontium isotopes (⁸⁷Sr/⁸⁶Sr) are used as geochemical tracers for paleomobility studies because they display predictable and stable patterns in ecosystems primarily controlled by the underlying geological regimes. While bedrock geology is stable over thousands of years, geomorphological processes can influence the ⁸⁷Sr/⁸⁶Sr in ecosystems over archeologically relevant timescales. Among these geomorphological processes, the deposition and reworking of volcanic sediments over Quaternary timescales are little studied but could be an important control of ⁸⁷Sr/⁸⁶Sr variations in many archeological regions. North Patagonia is a key archeological region to address animal and human movements, and a…

The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma

2016

Arginine-rich peptides are blockers of VR-1 channels with analgesic activity

2000

Vanilloid receptors (VRs) play a fundamental role in the transduction of peripheral tissue injury and/or inflammation responses. Molecules that antagonize VR channel activity may act as selective and potent analgesics. We report that synthetic arginine-rich hexapeptides block heterologously expressed VR-1 channels with submicromolar efficacy in a weak voltage-dependent manner, consistent with a binding site located near/at the entryway of the aqueous pore. Dynorphins, natural arginine-rich peptides, also blocked VR-1 activity with micromolar affinity. Notably, synthetic and natural arginine-rich peptides attenuated the ocular irritation produced by topical capsaicin application onto the eye…

Iron mineralogy and aqueous alteration from Husband Hill through Home Plate at Gusev Crater, Mars: Results from the Mössbauer instrument on the Spiri…

2008

[1] Spirit's Mossbauer (MB) instrument determined the Fe mineralogy and oxidation state of 71 rocks and 43 soils during its exploration of the Gusev plains and the Columbia Hills (West Spur, Husband Hill, Haskin Ridge, northern Inner Basin, and Home Plate) on Mars. The plains are predominantly float rocks and soil derived from olivine basalts. Outcrops at West Spur and on Husband Hill have experienced pervasive aqueous alteration as indicated by the presence of goethite. Olivine-rich outcrops in a possible mafic/ultramafic horizon are present on Haskin Ridge. Relatively unaltered basalt and olivine basalt float rocks occur at isolated locations throughout the Columbia Hills. Basalt and oliv…

Role for NK1 and NK2 receptors in the motor activity in mouse colon

2007

The present study examined the effects induced by endogenous and exogenous activation of NK(1) and NK(2) receptors on the mechanical activity of mouse proximal colon. Experiments were performed in vitro recording the changes in intraluminal pressure from isolated colonic segments. Electrical field stimulation in the presence of atropine and guanethidine produced a small relaxation, followed by nonadrenergic noncholinergic (NANC) contraction. SR140333, NK(1) receptor antagonist, or SR48968, NK(2) receptor antagonist, significantly reduced the contraction, although SR48968 appeared more efficacious. The co-administration of SR140333 and SR48968 virtually abolished the NANC contraction. [Sar(9…

Involvement of purinergic nerves in the NANC inhibitory junction potentials in pigeon oesophageal smooth muscle.

2004

1. Electrical field stimulation (EFS) (0.5 ms in train of 2-32 Hz for 300 ms) in smooth muscle of pigeon oesophagus, in the presence of atropine (1 microm) and guanethidine (1 microm), elicited an inhibitory response consisting of a transient hyperpolarization (inhibitory junction potential, IJP) associated with muscle relaxation. 2. Sodium nitroprusside (SNP, 100 microm) induced hyperpolarization correlated to mechanical relaxation. 3. The nitric oxide (NO) synthase inhibitor N(omega)-nitro-l-arginine (from 0.1 to 100 microm) caused a concentration-dependent reduction of electromechanical response to EFS indicating a role for NO in this response. 4. Apamin (1 microm) reduced both IJP and r…