Search results for "AhR"

Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification

2020

International audience; Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have been linked to PFBC. However, more than 50% of individuals affected by PFBC have no molecular diagnosis. We report four unrelated families presenting with initial learning difficulties and seizures and later psychiatric symptoms, cerebellar ataxia, extrapyramidal signs, and extensive calcifications on brain imaging. Through a combination of homozygosity mapping and exome sequencing, we mapped this phenotype to chromo…

Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems.

2017

Background 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality. The severity of toxicity is highly dependent on the aryl hydrocarbon receptor (AHR). Binding of TCDD to the AHR leads to changes in transcription of numerous genes. Studies evaluating the transcriptional changes brought on by TCDD may provide valuable insight into the role of the AHR in human health and disease. We therefore compiled a collection of transcriptomic datasets that can be used to aid the scientific community in better understanding the transcriptiona…

The Action of Di-(2-Ethylhexyl) Phthalate (DEHP) in Mouse Cerebral Cells Involves an Impairment in Aryl Hydrocarbon Receptor (AhR) Signaling

2018

Di-(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer in various plastic compounds, such as polyvinyl chloride (PVC), and products including baby toys, packaging films and sheets, medical tubing, and blood storage bags. Epidemiological data suggest that phthalates increase the risk of the nervous system disorders; however, the impact of DEHP on the brain cells and the mechanisms of its action have not been clarified. The aim of the present study was to investigate the effects of DEHP on production of reactive oxygen species (ROS) and aryl hydrocarbon receptor (AhR), as well as Cyp1a1 and Cyp1b1 mRNA and protein expression in primary mouse cortical neurons and glial cells in the in vit…

Dibutyl Phthalate (DBP)-Induced Apoptosis and Neurotoxicity are Mediated via the Aryl Hydrocarbon Receptor (AhR) but not by Estrogen Receptor Alpha (…

2016

Dibutyl phthalate (di-n-butyl phthalate, DBP) is one of the most commonly used phthalate esters. DBP is widely used as a plasticizer in a variety of household industries and consumer products. Because phthalates are not chemically bound to products, they can easily leak out to enter the environment. DBP can pass through the placental and blood–brain barriers due to its chemical structure, but little is known about its mechanism of action in neuronal cells. This study demonstrated the toxic and apoptotic effects of DBP in mouse neocortical neurons in primary cultures. DBP stimulated caspase-3 and LDH activities as well as ROS formation in a concentration (10 nM–100 µM) and time-dependent (3–…

Triclosan activates aryl hydrocarbon receptor (AhR)-dependent apoptosis and affects Cyp1a1 and Cyp1b1 expression in mouse neocortical neurons.

2016

Triclosan (TCS) is an antimicrobial agent that is used extensively in personal care and in sanitizing products, such as soaps, toothpastes, and hair products. A number of studies have revealed the presence of TCS in human tissues, such as fat, liver and brain, in addition to blood and breast milk. The aim of the present study was to investigate the impact of TCS on AhR and Cyp1a1/Cyp1b1 signaling in mouse neocortical neurons in primary cultures. In addition to the use of selective ligands and siRNAs, expression levels of mRNA and proteins as well as caspase-3 activity, reactive oxygen species (ROS) formation, and lactate dehydrogenase (LDH) release have been measured. We also studied the in…

Livländische Process-Ordnung

1701

CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease

2012

Background Based on their potency to control allergic diseases, regulatory T (Treg) cells represent a promising target for novel strategies to interfere with allergic airway inflammation. We have previously demonstrated that stimulation of the CD4 molecule on human Treg cells activates their suppressive activity in vitro and in vivo . Objective We sought to determine the effect of CD4-mediated Treg-cell activation on pulmonary inflammation in a humanized mouse model of allergic airway inflammation. Methods PBMCs obtained from donors allergic to birch pollen or from healthy donors were injected into NOD-severe combined immunodeficiency γc −/− mice, followed by allergen airway challenges and …

Ahrens Albert

2014

Fondatore dell'impresa palermitana omonima, con sede in piazza San Domenico, partecipa con successo alla prima Esposizione Agricola Regionale siciliana, di Palermo del 1902, e alla seconda Esposizione Regionale Agricola di Catania del 1907. Originario di Amburgo, Ahrens, dopo avere potenziato il settore delle stoffe, cura personalmente la progettazione di mobili, avvalendosi di artisti, architetti e imprese artigiane di orientamento modernista.

»…vzpomínám na něho ustavičně a přeji mu, aby se mu tatínek brzo vrátil«. O (terapeutycznej) roli pamięci w korespondencji więziennej Jana Zahradníčka

2020

Przedmiotem analizy są listy czeskiego poety Jana Zahradníčka wysyłane z komunistycznego więzienia do żony Marii w latach 1951–1960. Wybór to zapis zarówno życiowej traumy wynikającej z długo letniej izolacji oraz tragedii rodzinnej (śmierć dwóch córek), a jednocześnie świadectwo tego, że dzięki terapeutycznej roli pamięci autor przetrwał ów trudny czas. Punktem wyjścia są m. in. rozważania Aleidy Assmann, które co prawda prymarnie odnosiły się do pamięci kolektywnej społeczeństw dotkniętych traumatyczną przeszłością, ale mogą być także użyteczne dla rozpatrywanego tutaj studium przypadku jednostki.

Der Philosoph W. Solowioff und das Judentum [Philosoph W. Solowjow und das Judentum]

1927

Inhaltsverzeichnis: Vorwort 5 l. W. Solowioffs und das Judentum ll. W. Solowioffs Protest gegen den Antisemitismus 17 111. Das religiöse Gewissen erweckt in W. S. lnteresse für das Judentum 22 IV. W. Solowioffs Interesse für Juden 29 V. Die Bekanntschaft mit Juden macht W. S. zu ihrem Apologeten 32 VI. Juden zuverteidigen war für W. S. religiöse und patriotische Pflicht 35 Vll. W. Solowioffs jüdische Apologie 39 Vlll. W. S. über das Verhältnis des Christentums zum Judentum 46 IX. W. S. über die Beziehungen der Evangelien zum Talmud 57 X. W. Solowioffs originelle Polemik. 65 Xl. Widerlegung der nationalen Beschuldigungen 74 Xll. Widerlegung der ökonomischen Beschuldigung 77 Xlll. Wideflegung…