Search results for "Akt"
showing 10 items of 4399 documents
Holokausta reprezentācija filmās “Tēvs nakts”, “Ida” un “Viļņas geto”
2021
Bakalaura darba “Holokausta reprezentācija filmās “Tēvs nakts”, “Ida” un “Viļņas geto”” mērķis ir izpētīt ar kādiem kinematogrāfiskiem elementiem filmās “Tēvs nakts”, “Ida” un “Viļņas geto” tiek reprezentēts holokausts. Pētījuma problēmas ir – kādi ir režisoru izmantotie kino valodas elementi, kas veido holokausta reprezentāciju filmās un kā tiek atspoguļota holokausta problēma filmās, kas ir uzņemtas Baltijas valstu reģionā, izmantojot kino valodas elementus? Teorijas daļā tiek aplūkota semiotika, kino semiotika un tās elementi, naratīva teorija un kino naratīvs, reprezentācijas jēdziens, holokausta jēdziens un holokausta reprezentācija. Metodoloģiskajā daļā apskatītas divas kvalitatīvās p…
SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders
2022
Abstract Background The clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has not yet been established. Patients and methods A prospective multicenter registry-based cohort study conducted from December 2020 to December 2021 by the Spanish transplant and cell therapy group was used to analyze the relationship of antibody response at 3–6 weeks after full vaccination (2 doses) with breakthrough SARS-CoV-2 infection in 1394 patients with hematological disorders. Results At a median follow-up of 165 days after complete immunization, 37 out of 1394 (2.6%) developed breakthrough SARS-CoV-2 infection at median of 77 …
Pacientu pieredze par profilaktiskajām apskatēm ģimenes ārsta praksē
2017
Pētniecības darbs: Pacientu pieredze par profilaktiskajām apskatēm ģimenes ārstu praksē. Tēmas aktualitāte: Bieži nopietnas saslimšanas sākuma stadijā norit bez būtiskiem simptomiem, kad parādās raksturīgie simptomi saslimšana jau ir ieilgusi, grūti padodas ārstēšanai vai ārstēšana ir novēlota. Savlaicīga saslimšanas atradne, palīdz vieglāk atgūt veselību un darbaspējas, ka arī ietaupīt materiālajā sfērā, uz slimības ārstēšanas izdevumu rēķina. Savlaicīgu saslimšanas diagnostiku mums palīdz noteikt profilaktiskās apskates, tāpēc ir svarīgi apmeklēt savu ģimenes ārstu un veikt profilaktiskās apskates katru gadu. Darba mērķis ir noskaidrot pacientu pieredzi par profilaktiskajām apskatēm ģimen…
Cryo-EM structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution.
2022
AbstractThe origin of viruses remains an open question. While lack of detectable sequence similarity hampers the analysis of distantly related viruses, structural biology investigations of conserved capsid protein structures facilitate the study of distant evolutionary relationships. Here we characterize the lipid-containing ssDNA temperate bacteriophage ΦCjT23, which infects Flavobacterium sp. (Bacteroidetes). We report ΦCjT23-like sequences in the genome of strains belonging to several Flavobacterium species. The virion structure determined by cryogenic electron microscopy reveals similarities to members of the viral kingdom Bamfordvirae that currently consists solely of dsDNA viruses wit…
Further insights in the Tardigrada microbiome: phylogenetic position and prevalence of infection of four new Alphaproteobacteria putative endosymbion…
2019
Abstract Data from a previous study showed that microbiomes of six tardigrade species are species-specific and distinct from associated environmental microbes. We here performed a more in-depth analyses of those data, to identify and characterize new potential symbionts. The most abundant bacterial operational taxonomic units (OTUs) found in tardigrades are classified, and their prevalence in other environments is assessed using public databases. A subset of OTUs was selected for molecular phylogenetic analyses based on their affiliation with host-associated bacterial families in tardigrades. Almost 22.6% of the most abundant OTUs found do not match any sequence at 99% identity in the IMNGS…
Biological control of potato soft rot caused by Dickeya solani and the survival of bacterial antagonists under cold storage conditions
2018
Dickeya and Pectobacterium are responsible for causing blackleg of plants and soft rot of tubers in storage and in the field, giving rise to losses in seed potato production. In an attempt to improve potato health, biocontrol activity of known and putative antagonists was screened using in vitro and in planta assays, followed by analysis of their persistence at various storage temperatures. Most antagonists had low survival on potato tuber surfaces at 4 °C. The population dynamics of the best low‐temperature tolerant strain and also the most efficient antagonist, Serratia plymuthica A30, along with Dickeya solani as target pathogen, was studied with TaqMan real‐time PCR throughout the stora…
Propagule pressure increase and phylogenetic diversity decrease community’s susceptibility to invasion
2017
Background Invasions pose a large threat to native species, but the question of why some species are more invasive, and some communities more prone to invasions than others, is far from solved. Using 10 different three-species bacterial communities, we tested experimentally if the phylogenetic relationships between an invader and a resident community and the propagule pressure affect invasion probability. Results We found that greater diversity in phylogenetic distances between the members of resident community and the invader lowered invasion success, and higher propagule pressure increased invasion success whereas phylogenetic distance had no clear effect. In the later stages of invasion,…
New insight to the role of microbes in the methane exchange in trees: evidence from metagenomic sequencing
2021
Methane (CH4) exchange in tree stems and canopies and the processes involved are among the least understood components of the global CH4 cycle. Recent studies have focused on quantifying tree stems as sources of CH4 and understanding abiotic CH4 emissions in plant canopies, with the role of microbial in situ CH4 formation receiving less attention. Moreover, despite initial reports revealing CH4 consumption, studies have not adequately evaluated the potential of microbial CH4 oxidation within trees. In this paper, we discuss the current level of understanding on these processes. Further, we demonstrate the potential of novel metagenomic tools in revealing the involvement of microbes in the C…
Borrelia afzeliialters reproductive success in a rodent host
2018
The impact of a pathogen on the fitness and behaviour of its natural host depends upon the host–parasite relationship in a given set of environmental conditions. Here, we experimentally investigated the effects ofBorrelia afzelii,one of the aetiological agents of Lyme disease in humans, on the fitness of its natural rodent host, the bank vole (Myodes glareolus), in semi-natural conditions with two contrasting host population densities. Our results show thatB. afzeliican modify the reproductive success and spacing behaviour of its rodent host, whereas host survival was not affected. Infection impaired the breeding probability of large bank voles. Reproduction was hastened in infected females…
Comparable response of wild rodent gut microbiome to anthropogenic habitat contamination
2021
Abstract Species identity is thought to dominate over environment in shaping wild rodent gut microbiota, but it remains unknown whether the responses of host gut microbiota to shared anthropogenic habitat impacts are species-specific or if the general gut microbiota response is similar across host species. Here, we compare the influence of exposure to radionuclide contamination on the gut microbiota of four wild mouse species: Apodemus flavicollis, A. sylvaticus, A. speciosus and A. argenteus. Building on the evidence that radiation impacts bank vole (Myodes glareolus) gut microbiota, we hypothesized that radiation exposure has a general impact on rodent gut microbiota. Because we sampled (…