Search results for "AlON"

showing 10 items of 799 documents

Antioxidant Effect of a Probiotic Product on a Model of Oxidative Stress Induced by High-Intensity and Duration Physical Exercise

2021

This randomized double-blind and controlled single-center clinical trial was designed to evaluate the effect of a 6-week intake of a probiotic product (1 capsule/day) vs. a placebo on an oxidative stress model of physical exercise (high intensity and duration) in male cyclists (probiotic group, n = 22

0301 basic medicinemedicine.medical_specialtyLactobacillus caseiIsoprostanePhysiologymale cyclistsClinical Biochemistryantioxidative enzymesmedicine.disease_causePlaceboBiochemistryArticlelaw.invention03 medical and health scienceschemistry.chemical_compoundProbiotic0302 clinical medicineLactobacillus rhamnosusphysical exerciselawInternal medicineoxidative stressMedicineMolecular Biologychemistry.chemical_classificationbiologybusiness.industryGlutathione peroxidaselcsh:RM1-950oxidative stress biomarkers030229 sport sciencesCell BiologyMalondialdehydebiology.organism_classificationlcsh:Therapeutics. Pharmacology030104 developmental biologyEndocrinologyprobioticschemistrybusinessOxidative stressAntioxidants
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Corrigendum: Seabuckthorn Pulp Oil Protects against Myocardial Ischemia–Reperfusion Injury in Rats through Activation of Akt/eNOS

2016

Seabuckthorn (SBT) pulp oil obtained from the fruits of seabuckthorn [Hippophae rhamnoides L. (Elaeagnaceae)] has been used traditionally for its medicinal and nutritional properties. However, its role in ischemia–reperfusion (IR) injury of myocardium in rats has not been elucidated so far. The present study reports the cardioprotective effect of SBT pulp oil in IR-induced model of myocardial infarction in rats and underlying mechanism mediating activation of Akt/eNOS signaling pathway. Male albino Wistar rats were orally administered SBT pulp oil (5, 10, and 20 ml/kg/day) or saline for 30 days. On the day 31, ischemia was induced by one-stage ligation of left anterior descending coronary a…

0301 basic medicinenatural productsIschemia030204 cardiovascular system & hematologyPharmacologyseabuckthornmedicine.disease_causeLipid peroxidation03 medical and health scienceschemistry.chemical_compound0302 clinical medicineEnosLactate dehydrogenaseMedicineoxidative stressPharmacology (medical)Original ResearchPharmacologylehberrybiologybusiness.industrylcsh:RM1-950apoptosisCorrectionbiology.organism_classificationmedicine.diseaseMalondialdehydemyocardial ischemia–reperfusion injury030104 developmental biologylcsh:Therapeutics. PharmacologyBiochemistrychemistryinflammationedible oilPulp (tooth)businessReperfusion injuryOxidative stressFrontiers in Pharmacology
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2020

Nature is an indispensable source of new drugs, providing unique bioactive lead structures for drug discovery. In the present study, secalonic acid F (SAF), a naturally occurring ergochrome pigment, was studied for its cytotoxicity against various leukemia and multiple myeloma cells by the resazurin assay. SAF exhibited cytotoxic activity on both leukemia and multiple myeloma cells. Generally, multiple myeloma cells were more sensitive to SAF than leukemia cells. NCI-H929 cells were the most affected cells among the tested panel of multiple myeloma cell lines and were taken for further studies to assess the mode of action of SAF on those cells. Cell cycle analysis revealed that SAF induced …

0303 health sciencesChemistryCellular differentiationfungiOrganic ChemistryPharmaceutical ScienceCell migrationmedicine.diseaseAnalytical Chemistry03 medical and health sciencesLeukemia0302 clinical medicineChemistry (miscellaneous)Cell cultureApoptosis030220 oncology & carcinogenesisDrug DiscoverymedicineCancer researchMolecular MedicineCytotoxic T cellPhysical and Theoretical ChemistryCytotoxicitySecalonic acid030304 developmental biologyMolecules
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La fortificación del Reino de Valencia en la década de1640 a la luz de la revolución militar

2019

This article proposes a study of the traditions in defensive architecture that concurred in the projects designed by Spanish military engineers for the fortification of the Valencian frontier in 1648 and 1649, in the context of the War of Catalonia (1640-1652). For this it is essential to follow the route of the Valencian adaptations to the military revolution in the matter of fortifications throughout the sixteenth century and compare them with those brought to Valencia in 1641 by the Marquis of Leganes and his engineers from the school of Milan.

17th centuryfortification 197 224UNESCO::HISTORIAguerra de Cataluñarevolución militarKingdom of ValenciaRevista de historia moderna 529735 2019 45 7107717 La fortificación del Reino de Valencia en la década de1640 a la luz de la revolución militar Hernández Ruano [0210-9093 553 Estudis]military revolutionWar of CataloniaJavier This article proposes a study of the traditions in defensive architecture that concurred in the projects designed by Spanish military engineers for the fortification of the Valencian frontier in 1648 and 1649fortificaciónsiglo xVII:HISTORIA [UNESCO]in the context of the War of Catalonia (1640-1652). For this it is essential to follow the route of the Valencian adaptations to the military revolution in the matter of fortifications throughout the sixteenth century and compare them with those brought to Valencia in 1641 by the Marquis of Leganes and his engineers from the school of Milan. Reino de Valencia0210-9093 553 Estudis: Revista de historia moderna 529735 2019 45 7107717 La fortificación del Reino de Valencia en la década de1640 a la luz de la revolución militar Hernández Ruano
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Ajatuksella ja ahkeruudella kolmen suvun vaiheista neljältä vuosisadalta

2018

Kirja-arvio teoksesta Immonen, Perttu: Suomen rahvaan historia. Kolmen suvun elämää keskiajalta 1800-luvulle. Atena Kustannus Oy, 2017. 639 sivua. ISBN 978- 952-300-335-4. Perttu Immonen yhdistää teoksessaan mielenkiintoisesti ja elävästi mikro- ja makrohistorian varhaismodernin ajan Suomessa. Hän seuraa kronologisesti kolmen eri seutukunnan: LänsiSuomen Sastamalan, Itä-Suomen Rantasalmen ja Pohjanmaan Kokkolan tapahtumia. Poikkeuksellisen ankarien aikojen kuvauksesta muodostuu moniulotteinen ja alueiden erilaisia kohtaloita tarkasteleva analyysi. nonPeerReviewed

17th centurymakrohistoria18th century19th centurykäsityöläisethistoriaSastamalasääty-yhteiskuntaporvaristokeskiaikaKokkolatilallisetkirja-arvostelutpapistomikrohistoriasotilaatRantasalmi1600-lukukonteksti1800-luku1700-lukutalonpojatsäädyt
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The geometers of the cadastre of Catalonia (1720-1815)

2009

El Cadastre imposat a Catalunya després de la derrota austriacista en la guerra de Successió comportà la realització de nombroses operacions de mesura de terres. Aquests treballs foren duts a terme per un petit cos d’agrimensors anomenats geòmetres del reial tribut del Cadastre. Entre 1727 i 1815 n’hem identificat un total de vint-i-dos geòmetres. La creació d’aquesta figura va fer visible una professió fins llavors força desdibuixada a Catalunya. La cartografia cadastral és modesta, però alguns d’aquests geòmetres realitzaren també mapes més elaborats amb altres finalitats. After the Austrian defeat in the War of the Spanish Succession a cadastre was imposed to Catalonia. That entailed the…

18th C.CataloniaGeografíaUNESCO::HISTORIASurveyingGeociencias. Medio ambienteCatalunyaAgrimensuraCadastral mapsGeometerCadastreGrupo B:HISTORIA [UNESCO]GeòmetraSegle XVIII
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Non-invasive Geophysical Surveys in Search of the Roman Temple of Augustus Under the Cathedral of Tarragona (Catalonia, Spain): A Case Study

2018

An integrated geophysical survey has been conducted at the Tarragona’s Cathedral (Catalonia, NE Spain) with the aim to confirm the potential occurrence of archaeological remains of the Roman Temple dedicated to the Emperor Augustus. Many hypotheses have been proposed about its possible location, the last ones regarding the inner part of the Cathedral, which is one of the most renowned temples of Spain (twelfth century) evolving from Romanesque to Gothic styles. A geophysical project including electrical resistivity tomography (ERT) and ground probing radar (GPR) was planned over 1 year considering the administrative and logistic difficulties of such a project inside a cathedral of religious…

2D and 3D ERT surveyMineralogiaExcavacions arqueològiques -- Tarragona (Catalunya)010504 meteorology & atmospheric sciencesGPRApparent resistivity010502 geochemistry & geophysicsExcavacions arqueològiques01 natural sciences2d and 3d ert surveys90 - Arqueologia. PrehistòriaGeochemistry and PetrologySettore GEO/11 - Geofisica ApplicataElectrical resistivity tomographyArchaeological excavationsGeociências2D and 3D ERT surveysGeophysic0105 earth and related environmental sciencesRadarAugustus Roman TempleElectrical imagingTarragona (Catalunya) -- Arqueologia romanaNon invasiveTarragona (Catalonia)Astronomia / físicaExcavationGeophysicsEngenharias ivMineralogyElectrical-resistivity tomographyCatedral de TarragonaSurfaceGeophysicsGeographyArchaeological explorationGeophysical survey (archaeology)3d imageGeochemistry & geophysicsGround-penetrating radarTarragona (Catalunya)Geochemistry & GeophysicsGeochemistry and PetrologyGeophysicsCathedral of Tarragona
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Understanding the Significance of the Hypothalamic Nature of the Subthalamic Nucleus

2021

AbstractThe subthalamic nucleus (STN) is an essential component of the basal ganglia and has long been considered to be a part of the ventral thalamus. However, recent neurodevelopmental data indicated that this nucleus is of hypothalamic origin which is now commonly acknowledged. In this work, we aimed to verify whether the inclusion of the STN in the hypothalamus could influence the way we understand and conduct research on the organization of the whole ventral and posterior diencephalon. Developmental and neurochemical data indicate that the STN is part of a larger glutamatergic posterior hypothalamic region that includes the premammillary and mammillary nuclei. The main anatomic charact…

5neuroanatomyHypothalamusVentral anterior nucleusBiologyGlobus PallidusBasal GangliaMidbrainDiencephalonSubthalamic NucleusNeural PathwaysBasal gangliamedicineTheory/New Conceptsbehaviorsystem neuroscienceGeneral NeuroscienceGeneral MedicineIntegrative SystemsSubthalamic nucleusmedicine.anatomical_structurenervous systemHypothalamusNeuroscienceNucleusNeuroanatomyeneuro
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Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia
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Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis

2012

Monoclonal B Lymphocytosis (MBL) is defined as asymptomatic monoclonal B-cell expansion characterised by a CLL-phenotype, but with less than 5 x 10(9)/I circulating cells. Reactive oxygen species (ROS)-mediated cell damage plays a critical role in the initiation of carcinogenesis as well as in malignant transformation. The goal of this study was to perform an analysis of the oxidative stress statuses of patients affected by MBL and chronic lymphocytic leukaemia (CLL). We examined peripheral blood and urine specimens from 29 patients with MBL, 55 with CLL and 31 healthy subjects. There was a significant increase in the occurrence of the mutagenic base 8-oxo-2'-deoxiguanosine (8-oxo-dG) in th…

8-Oxo-dGMaleChronic lymphocytic leukaemiaCancer ResearchF-2-isoprostanesTime FactorsLymphocytosisDNA damageLymphocytosisBiologyDinoprostmedicine.disease_causeAntioxidantsLipid peroxidationchemistry.chemical_compoundMalondialdehydemedicineHumansCell damageChromatography High Pressure LiquidAgedchemistry.chemical_classificationB-LymphocytesReactive oxygen speciesGlutathione DisulfideDeoxyguanosineMonoclonal B LymphocytosisGlutathioneMiddle AgedMalondialdehydemedicine.diseaseGlutathioneLeukemia Lymphocytic Chronic B-CellOxidative StressOncologychemistryOxidative stress8-Hydroxy-2'-DeoxyguanosineImmunologyDNA damageFemalemedicine.symptomReactive Oxygen SpeciesBiomarkersOxidative stressDNA DamageCancer Letters
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