Search results for "AlON"
showing 10 items of 799 documents
Le prove oggettive
2014
Luigi Calonghi ha introdotto in Italia negli anni 50 le prove oggettive e ha proposto un metodo per la loro costruzione e validazione.
Verkostojen liikettä
2010
Sahalahden talonpoikaisten rusthollisukujen perhestrategiat 1721-1886
2006
The triumph of partisanship: political scientists in the public debate about Catalonia's independence crisis (2010-2018)
2021
Participation in the public debate constitutes one of the most evident avenues for political scientists to demonstrate the social relevance of the discipline. This article focuses on two questions: the types of roles political scientists adopt in their public interventions and the potential tensions between their public engagement and the epistemic norms regulating academic and research activities. We investigate these questions in the context of very salient political debates, involving a high degree of political confrontation, where basic political beliefs, values, identities, and interests are at stake. Focusing on the case of the public debate surrounding the Catalan inde pendence crisi…
Targeting the mevalonate pathway for improved anticancer therapy.
2009
The mevalonate pathway is important for the generation of isoprene moieties thereby providing the basis for the biosynthesis of molecules required for maintaining membrane integrity, steroid production and cell respiration. Additionally, isoprene precursors are indispensable for the prenylation of regulatory proteins such as Ras and Ras-homologous (Rho) GTPases. These low molecular GTP-binding proteins play key roles in numerous signal transduction pathways stimulated upon activation of cell surface receptors by ligand binding. Thus, Ras/Rho proteins eventually regulate cell proliferation, tumor progression and cell death induced by anticancer therapeutics. Lipid modification of Ras/Rho pro…
Inhibition of small G proteins of the Rho family by statins orClostridium difficiletoxin B enhances cytokine-mediated induction of NO synthase II
2000
In order to investigate the involvement of Ras and/or Rho proteins in the induction of the inducible isoform of nitric oxide synthase (NOS II) we used HMG-CoA reductase inhibitors (statins) and Clostridium difficile toxin B (TcdB) as pharmacological tools. Statins indirectly inhibit small G proteins by preventing their essential farnesylation (Ras) and/or geranylgeranylation (Rho). In contrast, TcdB is a glucosyltransferase and inactivates Rho-proteins directly. Human A549/8- and DLD-1 cells as well as murine 3T3 fibroblasts were preincubated for 18 h with statins (1–100 μM) or TcdB (0.01–10 ng ml−1). Then NOS II expression was induced by cytokines. NOS II mRNA was measured after 4–8 h by R…
Jean IV de Chalon-Arlay, un noble en révolte entre Bretagne et Bourgogne
2015
International audience
Kirjoittamisen ja rakkauden paloa : Juhani Aho sekä Elisabet Järnefeltin ja Minna Canthin kirjalliset salongit
2012
Tutkimukseni käsittelee Juhani Ahoa sekä Elisabet Järnefeltin ja Minna Canthin kirjallisia salonkeja. Tutkimuksessani kirjallisella instituutiolla ja kirjallisen elämän kuvaamisella on keskeinen rooli ja teoreettisesti se pohjautuu kirjallisuussosiologiaan. Tutkimukseni kuuluu kirjoittamisen historian tutkimuksiin. Tutkimuksessa kuvaan kirjallista elämää ja siihen liittyvien keskeisten henkilöiden, kirjailija Juhani Ahon, Elisabet ja Aleksander Järnefeltin sekä kirjailija Minna Canthin välisiä suhteita ja heidän elämäänsä hyvinkin tarkasti, ulkopuolisesta näyttäen jopa hivenen juoruilunomaisesti. Tämän tutkimuksen perusteella voidaan todeta, että kirjallisuussosiologian juuret ulottuvat Suo…