Search results for "Alcohol"

showing 10 items of 1798 documents

Synthesis and characterization of new 1,4 and 1,5-disubstituted glucopyranosyl 1,2,3-triazole by 1,3-dipolar cycloaddition

2009

Abstract A series of 1,4 and 1,5-disubstituted 1-(β- d -glucopyranosyl)-1,2,3-triazoles has been prepared in an efficient manner with excellent yields using the intermolecular 1,3-dipolar cycloaddition of 1-azido-2,3,4,6-tetra-O-acetyl-β- d -glucopyranose 2 to a variety of substituted alkynes phenylacethylene 3, propargyl alcohol 4, 2-butyn-1,4-diol, 5, 3-propargylbenzimidazole 6 and propargylpyrazole 7 in toluene. The reaction takes place with the formation of both 4- and 5-regioisomers.

123-TriazoleStereochemistryOrganic ChemistryIntermolecular forceCrystal structurePropargyl alcoholTolueneCycloadditionAnalytical ChemistryInorganic Chemistrychemistry.chemical_compoundchemistry13-Dipolar cycloadditionSpectroscopyJournal of Molecular Structure
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Impact of immunodepression and moderate alcohol consumption on coronary and other arterial disease events in an 11-year cohort of HIV-infected patien…

2012

Objective To investigate the relationship between response to antiretroviral therapy (ART), alcohol use and occurrence of a major coronary or other arterial disease event (CADE) in HIV-infected individuals. Design A cohort study. A Cox model was used to identify the correlates of a first occurrence of a major CADE. Setting The French ANRS CO8 APROCO-COPILOTE cohort was set up in 1997 to study clinical progression and patient-reported outcomes (PRO) after initiating a protease inhibitor-containing ART. Clinical data were retrieved from medical records. Self-administered questionnaires collected data on PRO and behaviours, including alcohol use. Participants Metabolic data were only available…

1683Pathologymedicine.medical_specialtyArterial disease03 medical and health sciences0302 clinical medicineAcquired immunodeficiency syndrome (AIDS)Internal medicinemedicineHiv infected patients1506030212 general & internal medicine17060303 health sciences030306 microbiologyProportional hazards modelbusiness.industryResearchGeneral Medicinemedicine.diseaseAntiretroviral therapy3. Good healthInfectious DiseasesCohort1714businessAlcohol consumptionCohort studyBMJ Open
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ChemInform Abstract: Recyclable Catalyst Reservoir: Oxidation of Alcohols Mediated by Noncovalently Supported Bis(imidazolium)-Tagged 2,2,6,6-Tetrame…

2014

2 2 6 6 tetramethylpiperidine 1 oxylChemistryAlcohol oxidationPolymer chemistryGeneral MedicineRecyclable catalystChemInform
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Application of replicated difference testing

2000

International audience; In a recent paper, Brockho€ and Schlich (1998, Handling replications in discrimination tests. Food Quality and Preference, 9(5), 303±312) proposed a statistically sound way of handling replications in di€erence testing. In the present paper, this new test is applied to the data obtained in six experiments on non alcoholic beverages, where triangle tests were intensively replicated (between eight and 60 times) with groups of subjects composed of 12±61 students. The paper aims to estimate in these practical situations the extent to which a group of panelists is heterogeneous towards the ability of detecting a sensory di€erence among two products. As the results indicat…

2. Zero hunger0303 health sciencesNutrition and Dietetics030309 nutrition & dieteticsdifference testNon alcoholic04 agricultural and veterinary sciences[SDV.IDA] Life Sciences [q-bio]/Food engineering040401 food scienceSensory analysis03 medical and health sciences0404 agricultural biotechnology[SDV.IDA]Life Sciences [q-bio]/Food engineeringStatisticsreplicationsEconometricsStatistical analysisPsychologyFood ScienceFood Quality and Preference
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Influence of cell immobilization on the production of benzaldehyde and benzyl alcohol by the white-rot fungi Bjerkandera adusta, Ischnoderma benzoinu…

1997

International audience; Three white-rot basidiomycetes, Bjerkandera adusta, Ischnoderma benzoinum and Dichomitus squalens, were cultivated on a liquid medium supplemented with l-phenylalanine, a precursor for benzaldehyde (bitter almond aroma) and benzyl alcohol. Remarkable amounts of benzaldehyde (587 mg l−1) were found in cultures of B. adusta. Immobilization of this fungus on polyurethane foam cubes allowed an 8.3-fold increase of the production of benzaldehyde and a 15-fold increase of the productivity as compared with non-immobilized cells. Aryl-alcohol oxidase activity was only detected in B. adusta. This activity was also significantly enhanced in immobilized cells, suggesting that i…

2. Zero hungerLaccase0303 health sciencesOxidase testbiology030306 microbiologyChemistryGeneral Medicinebiology.organism_classificationApplied Microbiology and BiotechnologyBenzaldehyde03 medical and health scienceschemistry.chemical_compoundBjerkandera adusta[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyBiochemistryManganese peroxidaseBenzyl alcoholCULTURE DE CELLULELigninAryl-alcohol oxidase[SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology030304 developmental biologyBiotechnology
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Menstrual problems and lifestyle among Spanish university women

2020

Menstrual problems affect many young women worldwide, conditioning both their academic performance and quality of life. This study sought to analyse the prevalence of menstrual problems and their possible relationship with lifestyle among Spanish university women, as part of a research project (UniHcos Project) involving a cohort of 11 Spanish universities with 7208 university students. A descriptive analysis was performed using the bivariate chi-square test and the Student&rsquo

2402.08 Hábitos AlimentariosHealth Toxicology and Mutagenesislcsh:Medicine:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Menstruation Disturbances [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Smoking [Medical Subject Headings]Logistic regression:Health Care::Health Care Quality Access and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Regression Analysis::Logistic Models [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicineMujeres universitarias - EspañaQuality of lifeTrastornos de la menstruaciónSurveys and QuestionnairesMedicine030212 general & internal medicineWomen college students - Spain:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence [Medical Subject Headings]Menstruation Disturbances:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Reproductive Control Agents::Contraceptive Agents [Medical Subject Headings]030219 obstetrics & reproductive medicine:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings]Test (assessment)University students:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]Dismenorrea:Anthropology Education Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings]Cohort:Anthropology Education Sociology and Social Phenomena::Education::Education Nonprofessional::Students [Medical Subject Headings]Medicina Preventiva y Salud PúblicaFemaleDietamedicine.symptomEstudiantes universitarios - EspañaDietinglifestyleUniversities:Anthropology Education Sociology and Social Phenomena::Education::Schools::Universities [Medical Subject Headings]LifestylesContext (language use):Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]Affect (psychology)ArticleEstilo de vida6310.09 Calidad de Vida03 medical and health sciencesDysmenorrheaMenstruation disordersHumansWomenuniversity studentsStudentsLife StyleLifestyles - Health aspects:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]Descriptive statisticsbusiness.industrymenstrual disorderslcsh:RPublic Health Environmental and Occupational Health:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology Social::Life Style [Medical Subject Headings]MujeresLifestyle3212 Salud PublicaMenstruation Disturbances - pathologyDietMenstrual disordersCross-Sectional Studies:Check Tags::Female [Medical Subject Headings]Spain:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings]Quality of Life:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Menstruation Disturbances::Dysmenorrhea [Medical Subject Headings]3201.08 GinecologíabusinessDemography
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Diastereoselective synthesis of 6-functionalized 4-aryl-1,3-oxazinan-2-ones and their application in the synthesis of 3-aryl-1,3-aminoalcohols and 6-…

2010

Abstract Halocyclocarbamation of benzyl N -(1-phenyl-3-butenyl)carbamates afforded 6-functionalized 4-aryl-1,3-oxazinan-2-ones with moderate to excellent diastereoselectivity depending on the N -substituent. Importantly, in contrast to reported cyclocarbamations of homoallylic carbamates, which are generally trans -diastereoselective, cyclization of N -unsubstituted Cbz-protected homoallylamines led to cis -1,3-oxazinan-2-ones, predominantly. The use of N -benzylated and in situ prepared N -silylated derivatives resulted however in trans -selectivity. Transition states are proposed to explain the stereochemical influence of the N -substituent on the cyclocarbamations. The functionalized 1,3…

3-AminoalcoholsStereochemistry3-ASYMMETRIC INDUCTION1SubstituentBiochemistrychemistry.chemical_compound4-dionesCHIRAL BUILDING-BLOCKDrug DiscoveryHEIMIA-SALICIFOLIAArylOrganic ChemistryCONCISE SYNTHESISHOMOALLYLIC AMINESTransition stateALPHA-AMINO-ACIDSChemistrySTEREOSELECTIVE-SYNTHESISCyclocarbamationSTREPTOMYCES-CLAVULIGERUSchemistryASYMMETRIC TOTAL-SYNTHESISINTRAMOLECULAR AMIDOALKYLATION3-Oxazinan-2-onesPiperidine-2
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Antidiabetic Drugs in NAFLD: The Accomplishment of Two Goals at Once?

2018

Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease in Western countries, accounting for 20–30% of general population and reaching a prevalence of 55% in patients with type 2 diabetes mellitus (T2DM). Insulin resistance plays a key role in pathogenic mechanisms of NAFLD. Many drugs have been tested but no medications have yet been approved. Antidiabetic drugs could have a role in the progression reduction of the disease. The aim of this review is to summarize evidence on efficacy and safety of antidiabetic drugs in patients with NAFLD. Metformin, a biguanide, is the most frequently used drug in the treatment of T2DM. To date 15 randomized controlled t…

3003medicine.medical_specialtymedicine.drug_classmedicine.medical_treatmentlcsh:Medicinelcsh:RS1-441Pharmaceutical Sciencehepatic cirrhosis030209 endocrinology & metabolismReviewChronic liver diseaseGastroenterologylcsh:Pharmacy and materia medica03 medical and health sciences0302 clinical medicineInsulin resistanceInternal medicineDiabetes mellitusDrug DiscoverymedicineBiguanidebusiness.industryLiraglutideInsulinlcsh:RFatty liverThiazolidinedionenutritional and metabolic diseasesnon-alcoholic fatty liver diseaseLiraglutidemedicine.diseaseMetforminMetforminHepatic cirrhosiMolecular Medicine030211 gastroenterology & hepatologyThiazolidinedionesnon-alcoholic steatohepatitisbusinessNon-alcoholic steatohepatitimedicine.drugPharmaceuticals (Basel, Switzerland)
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Mortalidad atribuible al alcohol en la Comunitat Valenciana en el año 2016

2018

Introducción: Esta demostrado que los hábitos de vida influyen en la salud de las personas, entre estos hábitos se encuentra ampliamente aceptado en nuestro país el consumo de alcohol, al que se asocia una gran mortalidad. El objetivo de este estudio ha sido calcular la mortalidad atribuible al alcohol en la Comunitat Valenciana en el año 2016. Material y métodos: Para el cálculo de mortalidad atribuible al alcohol se han utilizado 3 fuentes de datos principalmente: Los datos de consumo de alcohol fueron extraídos de la encuesta valenciana de salud del año 2016. Los datos de muertes; del instituto nacional de estadística, según sexos, franja de edad y categorías diagnósticas, junto con las …

:CIENCIAS MÉDICAS ::Epidemiología [UNESCO]causa de muertealcoholfracciones atribuibles al alcoholUNESCO::CIENCIAS MÉDICAS ::Epidemiologíamortalidadcomunitat valencianaenfermedad
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Papel de los receptores TLR4 en los mecanismos moleculares neuroinflamatorios y patológicos de la exposición al alcohol durante la adolescencia

2016

El consumo de alcohol en España ha registrado en las últimas décadas un importante crecimiento entre la población juvenil y adolescente, convirtiéndose en la droga más consumida por esta población y causando importantes problemas sociales, sanitarios y de salud pública, siendo las mujeres especialmente vulnerables a estos efectos. Durante la adolescencia, el cerebro sufre una maduración y remodelamiento funcional, lo que incluye un incremento de la conectividad neuronal, así como la modificación de la plasticidad sináptica en diferentes áreas cerebrales como la corteza prefrontal (CPF). Aunque los daños del alcohol en el cerebro adolescente han sido ampliamente estudiados, los mecanismos mo…

:CIENCIAS MÉDICAS ::Patología::Neuropatología [UNESCO]adolescenciaalcoholneuroinflamaciónUNESCO::CIENCIAS MÉDICAS ::Patología::Neuropatología
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