Search results for "Alcohol"

Organocatalytic Alcohol Oxidation Catalyzed by Recyclable TEMPO-functionalized [60]fullerene

2014

C60-TEMPO-IL hybrid: “release and catch” organocatalyst for the oxidation of alcohols

2014

Sodium oxybate therapy for the treatment of alcohol withdrawal syndrome and the maintenance of alcohol abstinence

2017

Gamma-hydroxybutyrate (GHB or sodium oxybate) is both an exogenous and endogenous molecule with neuromodulator properties. In the United States, GHB is an approved drug for the treatment of narcolepsy and narcolepsy with cataplexy in adults. In some European Union countries, sodium oxybate is applied for the treatment of opioid and alcohol withdrawal.

Preliminary magnetic resonance relaxometric analysis of Fricke gel dosimeters produced with polyvinyl alcohol and glutaraldehyde

2017

This work describes the preliminary analysis of Fricke gels dosimeters characterized by a new formulation making use of a matrix of polyvinyl alcohol cross-linked by adding glutaraldehyde and analyzed by means of nuclear magnetic resonance relaxometry. In previous optical studies, these gels have shown promising dosimetric features in terms of photon sensitivity and low diffusion of ferric ions produced after irradiation. In this work, we used a portable nuclear magnetic resonance relaxometer to measure the relaxation times (which are important for dosimetric applications) of these gel materials. For this purpose, we performed a study for optimizing the acquisition parameters with a nuclear…

Marcadores genéticos dopaminérgicos, serotoninérgicos y de la monoamino-oxidasa (MAO) relacionados con la adicción a los opiáceos, a la cocaína y al …

2013

Introducción: la genética está experimentando un avance espectacular y se postula como una herramienta importante para aportar nuevos descubrimientos en trastornos complejos como son las adicciones. En el presente trabajo se ha realizado un estudio de asociación genética de polimorfismos VNTR, un estudio familiar y un estudio mixto de asociación genético-familiar en una muestra de policonsumidores con adicción al alcohol, la cocaína y los opiáceos. Material y métodos: en una muestra de 302 policonsumidores, se recogieron y genotiparon muestras a partir de células epiteliales de la mejilla para observar las frecuencias de marcadores de las vías dopaminérgica, serotoninérgica y de la MAO en l…

The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS

2007

Membrane fission is an essential process in membrane trafficking and other cellular functions. While many fissioning and trafficking steps are mediated by the large GTPase dynamin, some fission events are dynamin independent and involve C-terminal-binding protein-1/brefeldinA-ADP ribosylated substrate (CtBP1/BARS). To gain an insight into the molecular mechanisms of CtBP1/BARS in fission, we have studied the role of this protein in macropinocytosis, a dynamin-independent endocytic pathway that can be synchronously activated by growth factors. Here, we show that upon activation of the epidermal growth factor receptor, CtBP1/BARS is (a) translocated to the macropinocytic cup and its surroundi…

Restrictions for reimbursement of interferon-free direct-acting antiviral drugs for HCV infection in Europe

2018

All-oral direct-acting antiviral drugs (DAAs) for hepatitis C virus, which have response rates of 95% or more, represent a major clinical advance. However, the high list price of DAAs has led many governments to restrict their reimbursement. We reviewed the availability of, and national criteria for, interferon-free DAA reimbursement among countries in the European Union and European Economic Area, and Switzerland. Reimbursement documentation was reviewed between Nov 18, 2016, and Aug 1, 2017. Primary outcomes were fibrosis stage, drug or alcohol use, prescriber type, and HIV co-infection restrictions. Among the 35 European countries and jurisdictions included, the most commonly reimbursed …

Alcohol Consumption and Long-Term Labor Market Outcomes

2017

This paper examines whether alcohol consumption is related to long-term labor market outcomes. We use twin data for Finnish men and women matched to register-based individual information on employment and earnings. The twin data allow us to account for the shared environmental and genetic factors. The quantity of alcohol consumption was measured by weekly average consumption using self-reported data from three surveys (1975, 1981 and 1990). The average of an individual's employment months and earnings were measured in adulthood over the period 1990–2009. The models that account for the shared environmental and genetic factors reveal that former drinkers and heavy drinkers both have almost 2…

Reasoned and implicit processes in heavy episodic drinking : An integrated dual‐process model

2020

Objectives: University students commonly engage in heavy episodic drinking (HED), which contributes to injury risk, deleterious educational outcomes, and economic costs. Identification of the determinants of this risky behaviour may provide formative evidence on which to base effective interventions to curb HED in this population. Drawing from theories of social cognition and dual‐process models, this study tested key hypotheses relating to reasoned and implicit pathways to action for HED in a sample of Australian university students who drink alcohol. Design: A two‐wave correlational design was adopted. Methods: Students (N = 204) completed self‐reported constructs from social cognition th…

Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease.

2022

Background & Aims: Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of macrophage scavenger receptor 1 (MSR1, CD204) remains incompletely understood. Methods: A total of 170 NAFLD liver biopsies were processed for transcriptomic analysis and correlated with clinicopathological features. Msr1(-/-) and wild-type mice were subjected to a 16-week high-fat and high-cholesterol diet. Mice and ex vivo human liver slices were treated with a monoclonal antibody against MSR1. Genetic susceptibility was assessed using genome-wide association study data from 1,483 patients with NAFLD and 430,101 participants of the U…