Search results for "Alcoholisme"
showing 5 items of 5 documents
The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol
2021
N-acetylcysteine (NAC) is a prodrug that is marketed as a mucolytic agent and used for the treatment of acetaminophen overdose. Over the last few decades, evidence has been gathered that suggests the potential use of NAC as a new pharmacotherapy for alcohol use disorder (AUD), although its mechanism of action is already being debated. In this paper, we set out to assess both the potential involvement of the glutamate metabotropic receptors (mGluR) in the possible dual effect of NAC administered at two different doses and NAC’s effect on ethanol-induced activation. To this aim, 30 or 120 mg/kg of NAC was intraperitoneally administered to rats with the presence or absence of the negative allo…
Physiological and Psychological Effects of a High Dose of Alcohol in Young Men and Women
2014
The objective of this study was to evaluate the effects of a high dose of alcohol on physiological and psychological parameters in young men and women with a previous history of alcohol consumption. Systolic and diastolic blood pressure, heart rate, state anxiety, attention, time estimation and manual dexterity were registered before (phase 1) and after (phase 2) intake of alcohol (38.4 g) or a non-alcoholic beverage. Trait anxiety was registered in phase 2 only. The results showed that acute consumption of a high dose of alcohol: i) improves attention in men (although the performance of alcohol consumers was not better than that of non-consumers); ii) blocks the systolic blood pressure hab…
Bipolar disorder comorbid with alcohol use disorder: focus on neurocognitive correlates
2015
Bipolar disorder (BD) and alcohol use disorders (AUDs) are usually comorbid, and both have been associated with significant neurocognitive impairment. Patients with the BD-AUD comorbidity (dual diagnosis) may have more severe neurocognitive deficits than those with a single diagnosis, but there is paucity of research in this area. To explore this hypothesis more thoroughly, we carried out a systematic literature review through January 2015. Eight studies have examined the effect of AUDs on the neurocognitive functioning of BD patients. Most studies found that BD patients with current or past history of comorbid AUDs show more severe impairments, especially in verbal memory and executive cog…
AUDIT, AUDIT-C y AR2I para evaluar el Binge Drinking en universitarios españoles
2020
La identificación de los jóvenes que realizan un consumo intensivo de alcohol (CIA) es una prioridad en el ámbito de la prevención e intervención, dadas las consecuencias bio-psico-sociales que genera. Objetivo. Verificar qué versión del AUDIT constituye el instrumento de screening más adecuado en esta población, partiendo de una operacionalización más precisa del CIA. Método. Se ha realizado un muestreo de conveniencia en el que han participado 190 jóvenes consumidores de alcohol entre 18 y 22 años (73.7% mujeres), que cumplimentaron un autoregistro de consumo de alcohol, el AUDIT y AR2I. Resultados. El análisis de conglomerados por sexos muestra 5 grupos de jóvenes CIA, en función de la e…
Predictors of weekly alcohol drinking and alcoholrelated problems in binge-drinking undergraduates
2015
Texto en inglés e español Las importantes implicaciones que genera el consumo intensivo de alcohol entre los jóvenes justifican el interés por determinar qué factores predicen su aparición. Concretamente, en este estudio se analiza el papel de la personalidad y edad de inicio en el consumo de alcohol en la predicción del consumo semanal de alcohol, y de todas estas variables en la predicción del número de consecuencias asociadas al consumo en jóvenes universitarios. Se evalúan 213 consumidores intensivos de primer curso de la Universidad Complutense de Madrid. Todos ellos cumplimentaron un autoregistro de consumo, el BIS-11, el NEO-FFI y el IECI de consecuencias asociadas a la ingesta. Los …