Search results for "Alexander"
showing 10 items of 37 documents
Coexpresión de NG2/GFAP tras la diferenciación en células transfectadas con las mutaciones de GFAP y en células procedentes de gliomas indiferenciados
2020
Resumen: Introducción: La enfermedad de Alexander es una enfermedad rara causada por mutaciones en el gen que codifica la proteína glial ácida fibrilar (GFAP). En un estudio previo hemos observado que la diferenciación de neuroesferas transfectadas con estas mutaciones genera un tipo celular que comparte la expresión de GFAP y NG2. Objetivos: Determinar el efecto de las mutaciones en marcadores moleculares en comparación con células de glioma diferenciados que expresan simultáneamente GFAP y NG2. Métodos: Se utilizaron muestras de glioblastoma humana (GLM) y neuroesferas procedentes de rata transfectadas con mutaciones de GFAP para el análisis de la expresión tras diferenciación de GFAP y N…
Myelin changes in Alexander disease
2018
Introduction: Alexander disease (AxD) is a type of leukodystrophy. Its pathological basis, along with myelin loss, is the appearance of Rosenthal bodies, which are cytoplasmic inclusions in astrocytes. Mutations in the gene coding for glial fibrillary acidic protein (GFAP) have been identified as a genetic basis for AxD. However, the mechanism by which these variants produce the disease is not understood. Development: The most widespread hypothesis is that AxD develops when a gain-of-function mutation causes an increase in GFAP. However, this mechanism does not explain myelin loss, given that experimental models in which GFAP expression is normal or mutated do not exhibit myelin disorders. …
Alexander Disease Mutations Produce Cells with Coexpression of Glial Fibrillary Acidic Protein and NG2 in Neurosphere Cultures and Inhibit Differenti…
2017
Background Alexander disease (AxD) is a rare disease caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). The disease is characterized by presence of GFAP aggregates in the cytoplasm of astrocytes and loss of myelin. Objectives Determine the effect of AxD-related mutations on adult neurogenesis. Methods We transfected different types of mutant GFAP into neurospheres using the nucleofection technique. Results We find that mutations may cause coexpression of GFAP and NG2 in neurosphere cultures, which would inhibit the differentiation of precursors into oligodendrocytes and thus explain the myelin loss occurring in the disease. Transfection produces cells that diff…
Da Baumgarten a Baumgarten. Siegmund Jacob Baumgarten e la fondazione dell'estetica moderna
2013
Il presente articolo intende analizzare il contributo di Siegmund Jacob Baumgarten alla nuova disciplina estetica battezzata dal fratello. Se ne esamineranno in particolare alcune conclusioni ermeneutiche, dogmatiche, morali, antropologiche e poetiche nel più ampio dibattito del periodo.
Aleksandra Zāmeļa 1925. gadā ievāktais mazā zvaguļa herbārijs
2019
Raksts par 2019. gada auga mazā zvaguļa Rhinanthus minor herbāriju, ko 1925. gada 20. jūnijā ievācis latviešu botāniķis un iedzimtības pētnieks Aleksandrs Zāmelis, un kas glabājas Latvijas Universitātes Muzeja Botānikas un mikoloģijas kolekciju Latvijas Herbārijā (Herbarium Latvicum).
THE CAUSAL ROOTS OF INTEGRATION AND THE UNITY OF CONSCIOUSNESS
2016
A fundamental feature of consciousness is unity. The problem is whether unity is compatible both with the physical underpinnings of conscious experience and with the fabric of the physical world in general.
Pētera Šmita sarakste ar Jāni Misiņu sakarā ar lūgumu atsūtīt lugas Vladivostokas Latviešu biedrības teātrim
1916
P. Šmits lūdz J. Misiņu atsūtīt Vladisvotokas Latviešu biedrības teātrim dažādu autoru - gan latviesu, gan cittautu autoru kopumā 40 lugas, Dziesmu lugām vēlētos arī notis. Ja nu gadījuma pats nevarot, tad lai lūgumu nododot citam grāmatu veikalam.
On orderability of fibred knot groups
2003
It is known that knot groups are right-orderable, and that many of them are not bi-orderable. Here we show that certain bred knots in S 3 (or in a homology sphere) do have bi-orderable fundamental group. In particular, this holds for bred knots, such as 41, for which the Alexander polynomial has all roots real and positive. This is an application of the construction of orderings of groups, which are moreover invariant with respect to a certain automorphism.
Separation properties of continuous maps in codimension 1 and geometrical applications
1992
Abstract Nuno Ballesteros, J.J. and M.C. Romero Fuster, Separation properties of continuous maps in codimension 1 and geometrical applications, Topology and its Applications 46 (1992) 107-111. We show that the image of a proper closed continuous map, f , from an n -manifold X to an ( n + 1)-manifold Y , such that H 1 (Y; Z 2 ) =0 , separates Y into at least two connected components provided the self-intersections set of f is not dense in any connected component of Y . We also obtain some geometrical applications.
De capitanías generales y tesorerías militares: el control financiero y sus dilemas en tiempos de Alejandro Farnesio (siglo XVI)
2015
A partir de fuentes inéditas, este artículo analiza qué tipo de medidas administrativas estableció la Corona en la década de 1580 para someter la gestión financiera de la capitanía general del ejército de Flandes a un control más riguroso. también proporciona evidencias documentales de por qué la Corona desistió en su empeño fiscalizador en esta misma década. Con ello, el artículo muestra la disyuntiva de incrementar o rebajar el control que se planteaba en coyunturas clave. Además, pone de manifiesto el apoderamiento que la función fiscalizadora del consumo de fondos militares podía proporcionar en un escenario de guerra; la resistencia que semejante apoderamiento suscitaba entre los agent…