Search results for "Alter"
showing 10 items of 2368 documents
Quantitative Vibrational Spectrometry in the 21st Century: A Scientometric Evaluation
2005
Abstract The state of the art of research on vibrational spectrometry–based quantitative methodologies was evaluated from the literature compiled in Analytical Abstracts from 1980. Medium and near infrared, Raman spectrometry, and photoacoustic methods of analysis were considered. The evolution of the number of published papers, the distribution of the literature as a function of the different application fields in which the vibrational methods were employed, and a study of the impact on this area of chemometric and automation studies clearly shows that, from the 1990s until now, the importance of vibrational spectrometry in application analysis has grown to reach maturity. This field provi…
Adopting magnetocaloric heat pumping and refrigeration for electrical vehicle
2017
International audience; Refrigeration process is based on conventional gas compression and expansion techniques. However, this technique has numerous disadvantages since it generates greenhouse gas and is partly responsible for global warming. This paper exposes analternative method: magnetocaloric refrigeration that presents the advantage to combine high-energy efficiency and respect of theenvironment. Magnetic heat pumping and cooling is compared to conventional method applied on vehicle air conditioning system.Simulation results are used to demonstrate the approach.
Efficient Addition of Acid Enediolates to Epoxides
2004
We report new conditions to facilitate the addition of dianions of carboxylic acids to epoxides as an alternative method to the use of aluminum enolates. These conditions require the use of a sub-stoichiometric (10%) amount of amine for dianion generation and the previous activation of the epoxide with LiCl. Other Lewis acids have been shown to be less effective. Yields are good but only low diastereoselectivity is attained, which has not been controlled despite attempts at optimization. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Detection of Cancer Stem Cells Using AC133 Antibody
2012
The cancer stem cell (CSC) model postulates that tumors are formed and maintained by a small population of undifferentiated cells, characterized by unique self-renewal properties and malignant potential. As CSCs survive chemotherapy inducing tumor recurrence, the specific targeting and eradication of these cells represents an important therapeutic challenge in cancer cure. Recent findings on CD133, a pentaspan transmembrane glycoprotein, discuss its application in the identification and isolation of SCs from cancerous tissues. However, the appropriateness of this protein constitutes an ongoing discussion. The expression pattern is debated and several issues highlight the need for additional…
Erythrocytes labeled with [18F]SFB as an alternative to radioactive CO for quantification of blood volume with PET
2013
Inhaled radioactive CO is currently the tracer of choice for blood volume quantification by positron emission tomography (PET). This measurement is of great interest for several clinical and research applications. However, owing to the short half-life of the radiolabeled CO, it can only be used in centers equipped with a cyclotron. In the present work, we propose an alternative method to label the red blood cells with [(18) F] in order to obtain blood volume measurements by PET. The use of the radioactive synthon [(18) F] N-succinimidyl 4-[(18) F]fluorobenzoate ([(18) F]SFB) was evaluated for erythrocyte labeling and PET blood volume imaging. The images provided by [(18) F]SFB labeled eryth…
Qip-Mass Spectrometry in High Risk Smoldering Multiple Myeloma Patients Included in the GEM-CESAR Trial: Comparison with Conventional and Minimal Res…
2019
Introduction: The GEM-CESAR trial is a potentially curative strategy for high-risk smoldering multiple myeloma (HRsMM) patients in which the primary endpoint is the assessment of bone marrow minimal residual disease negativity by next generation flow (NGF). However, alternative methods of tumor burden evaluation in serum, like Quantitative Immunoprecipitation Mass Spectrometry (QIP-MS), a polyclonal antibody-based technology to identify intact immunoglobulins, have been also evaluated. Patients and Methods: Ninety HRsMM patients included in the GEM-CESAR trial received six 4-weeks cycles of carfilzomib, lenalidomide and dexamethasone followed by high dose melphalan and ASCT and 2 further cy…
Structural Reforms in Banking: The Role of Trading
2017
In the wake of the recent financial crisis, significant regulatory actions have been taken aimed at limiting risks emanating from trading in bank business models. Prominent reform proposals are the Volcker Rule in the U.S., the Vickers Report in the UK, and, based on the Liikanen proposal, the Barnier proposal in the EU. A major element of these reforms is to separate "classical" commercial banking activities from securities trading activities, notably from proprietary trading. While the reforms are at different stages of implementation, there is a strong ongoing discussion on what possible economic consequences are to be expected. The goal of this paper is to look at the alternative approa…
Insider Trading and Market Behaviour Around Takeover Announcements in the Spanish Market
2002
As microstructure models assume informational asymmetries among investors, the possibility of insider trading is a sound reason for liquidity suppliers to increase the bid-ask spread. In this way, the tested effect that takeover announcements have on target firm returns becomes a strong motive for trading with insider information. In this paper we firstly investigate whether liquidity suppliers value the possibility of trading with informed agents in this sort of event. We analyse the adverse selection cost from bid-ask spread behaviour around takeover announcements. We find that liquidity suppliers enlarge adverse selection cost suggesting that they value the possibility of facing to insid…
Where Has All the Trading Gone? A Network Approach to European Stock Exchanges and Alternative Trading Venue
2011
This paper investigates the network features of European trading venues by analyzing the behavior of simultaneously quoted stock. Equity trading venues include both regulated Stock Exchanges (SEs) and Alternative Trading Venues (ATVs) and these represent the nodes of our network. The connections among these nodes are determined by choices of investors to exploit various venues in which a stock may be traded. Using trading volume data of nearly 22,000 equities we use social network analysis to measure prestige and connectivity between the various trading venues between 2005 and 2009. We find that the evolution of ATVs (including multi-lateral trading venues BATS, Chi-X and Turquoise, as well…
Electromechanical Numerical Analysis of an Air-Core Pulsed Alternator via Equivalent Network Formulation
2017
In this paper, the numerical analysis on an air-core pulsed alternator is presented. Since compulsators are characterized by very fast electromechanical transients, their accurate analysis requires strong coupling between the equations governing the electrical and the mechanical behaviors. The device is investigated by using a dedicated numerical code capable to take into account eddy currents, compensating windings, as well as the excitation/control circuits. Furthermore, the code is capable of modeling centrifugal forces and vibrations acting on the shaft due to electric and mechanical unbalances or to misalignments of the shaft from its centered position. This makes the code a very power…