Search results for "Alternatives"
showing 10 items of 37 documents
Universality of the Triangular Theory of Love: Adaptation and Psychometric Properties of the Triangular Love Scale in 25 Countries
2021
The Triangular Theory of Love (measured with Sternberg’s Triangular Love Scale – STLS) is a prominent theoretical concept in empirical research on love. To expand the culturally homogeneous body of previous psychometric research regarding the STLS, we conducted a large-scale cross-cultural study with the use of this scale. In total, we examined more than 11,000 respondents, but as a result of applied exclusion criteria, the final analyses were based on a sample of 7332 participants from 25 countries (from all inhabited continents). We tested configural invariance, metric invariance, and scalar invariance, all of which confirmed the cultural universality of the theoretical construct of love …
Survey of methods to visualize alternatives in multiple criteria decision making problems
2012
When solving decision problems where multiple conflicting criteria are to be considered simultaneously, decision makers must compare several different alternatives and select the most preferred one. The task of comparing multidimensional vectors is very demanding for the decision maker without any support. Different graphical visualization tools can be used to support and help the decision maker in understanding similarities and differences between the alternatives and graphical illustration is a very important part of decision support systems that are used in solving multiple criteria decision making problems. The visualization task is by no means trivial because, on the one hand, the grap…
Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
2012
Hepatotoxicity is a major reason for drug nonapprovals and withdrawals. The multiparametric analysis of xenobiotic toxicity at the single cells level using flow cytometry and cellular imaging-based approaches, such as high-content screening (HCS) technology, could play a key role in the detection of toxicity and the classification of compounds based on patterns of cellular injury. This study aimed to develop and validate a practical, reproducible, in vitro multiparametric cell-based protocol to assess those drugs that are potentially hepatotoxic to humans and to suggest their mechanisms of action. The assay was applied to HepG2 human cell line cultured in 96-well plates and exposed to 78 di…
Xenobiotic metabolizing enzyme activities and viability are well preserved in EDTA-isolated rat liver parenchymal cells after cryopreservation
1995
Rat liver parenchymal cells (PC) were isolated by EDTA perfusion and were purified by a subsequent Percoll centrifugation. The isolated PC had a viability of 95%, as judged by trypan blue exclusion. Freshly isolated PC were cryopreserved with an optimized protocol in a computer-controlled freezer. After thawing, the PC still retained a viability of 89%. The activities of representative xenobiotic metabolizing enzymes were compared between freshly isolated and cryopreserved PC after thawing. The cytochrome P450 content and the cytochrome P450 2C11 isoenzyme activity, determined by hydroxylation of testosterone in intact cells, were not affected by the cryopreservation. The following phase II…
Contact Sensitizers Specifically Increase MHC Class II Expression on Murine Immature Dendritic Cells
2000
Contact sensitivity is a T-cell-mediated immune disease that can occur when low-molecular-weight chemicals penetrate the skin. In vivo topical application of chemical sensitizers results in morphological modification of Langerhans cells (LC). Moreover, within 18 h, LC increase their major histocompatibility complex (MHC) class II antigens expression and migrate to lymph nodes where they present the sensitizer to T lymphocytes. We wanted to determine if such an effect could also be observed in vitro. However, because of the high genetic diversity encountered in humans, assays were performed with dendritic cells (DC) obtained from a Balb/c mouse strain. The capacity of a strong sensitizer, DN…
Infrared lessons for ultraviolet gravity: the case of massive gravity and Born-Infeld
2014
We generalize the ultraviolet sector of gravitation via a Born-Infeld action using lessons from massive gravity. The theory contains all of the elementary symmetric polynomials and is treated in the Palatini formalism. We show how the connection can be solved algebraically to be the Levi-Civita connection of an effective metric. The non-linearity of the algebraic equations yields several branches, one of which always reduces to General Relativity at low curvatures. We explore in detail a {\it minimal} version of the theory, for which we study solutions in the presence of a perfect fluid with special attention to the cosmological evolution. In vacuum we recover Ricci-flat solutions, but also…
On gravitational waves in Born-Infeld inspired non-singular cosmologies
2017
We study the evolution of gravitational waves for non-singular cosmological solutions within the framework of Born-Infeld inspired gravity theories, with special emphasis on the Eddington-inspired Born-Infeld theory. We review the existence of two types of non-singular cosmologies, namely bouncing and asymptotically Minkowski solutions, from a perspective that makes their features more apparent. We study in detail the propagation of gravitational waves near these non-singular solutions and carefully discuss the origin and severity of the instabilities and strong coupling problems that appear. We also investigate the role of the adiabatic sound speed of the matter sector in the regularisatio…
Intersecciones críticas. Experiencias y estrategias desde la museología y el feminismo gitano, bajo el prisma del covid-19 = Critical Intersections. …
2020
La pandemia de 2020 enfrentó las áreas que tratan la memoria desde los márgenes con la necesidad de transformar sus experiencias en estrategias con potencial de futuro. El artículo busca reflejar la intersección entre dos campos de acción cultural comprometida: el de algunos museos valencianos y el de las asociaciones de mujeres gitanas, vistas también desde el ámbito local. El objeto de nuestro análisis son dos vertientes de la actuación cultural emancipadora: las experiencias, fenómenos a menudo caóticos y coyunturales, y las estrategias razonadas, que unen prácticas del conocimiento crítico hasta ahora no contiguas. El estado de alarma definió estas ramas estratégicas como inclusión digi…
Is There Life Outside of the European Union? Lower Silesians’ Opinions About the Alternatives to the EU Membership
2017
This paper answers the question about the alternatives to the European Union membership (and its consequences) conceptualised by the inhabitants of Lower Silesia. To achieve this goal, this text delivers and discusses the empirical data, both quantitative and qualitative, answering the sub-questions if and how their lives have changed as a result of the accession to the EU as well as what are the alternatives, namely: How would our lives have looked like if Poland had not joined the EU in 2004? The article is empirical at its heart. It is built on some fresh data from an extensive research project conducted in 2014 – at the occasion of the tenth anniversary of the EU ‘big bang’ enlargement.…
Obesogen effects after perinatal exposure of 4,4′-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice
2016
International audience; Bisphenol A were removed from consumer products and replaced by chemical substitutes such as Bisphenol S (BPS). Based on their structural similarity, BPS may be obesogen like Bisphenol A in mice. Our objective was to determine the impact of BPS on lipid homeostasis in C57B1/6 mice after perinatal and chronic exposure. Pregnant mice were exposed to BPS via the drinking water (0.2; 1.5; 50 mu g/kg bw/d). Treatment began at gestational day 0 and continued in offspring up to 23-weeks old. Then, offspring mice were fed with a standard or high fat diet. The body weight, food consumption, fat mass and energy expenditure were measured. A lipid load test was performed to chec…