Search results for "Alzheimer"
showing 10 items of 706 documents
The Role of APC/C-Cdh1 in Alzheimer's disease
2016
Alzheimer’s disease (AD) is the most common cause of dementia among elderly individuals above 65 years. Estimations suggest that there are currently about 47.5 million people worldwide suffering from dementia, of which 60-70% are AD cases (World Health Organization, 2015). It is an irreversible disease of progressive nature, which leads to deterioration in cognitive functions beyond what is normal in a healthy aging process. Among the affected cognitive functions are memory, thinking skills and orientation. AD is one of the major causes of disability among older people and has a big impact on socio-economical capacities. There is currently no treatment to cure AD and it is a very active fie…
Changes in visual function and retinal structure in the progression of Alzheimer's disease
2019
Background Alzheimer's Disease (AD) can cause degeneration in the retina and optic nerve either directly, as a result of amyloid beta deposits, or secondarily, as a result of the degradation of the visual cortex. These effects raise the possibility that tracking ophthalmologic changes in the retina can be used to assess neurodegeneration in AD. This study aimed to detect retinal changes and associated functional changes in three groups of patients consisting of AD patients with mild disease, AD patients with moderate disease and healthy controls by using non-invasive psychophysical ophthalmological tests and optical coherence tomography (OCT). Methods We included 39 patients with mild AD, 2…
Zinc Finger Proteins in Neuro-Related Diseases Progression
2021
Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, zinc finger proteins can regulate gene expression at the transcriptional and translational levels. In terms of neurological diseases, numerous studies have shown that many zinc finger proteins are associated with neurological diseases. The purpose of this review is to summarize the types and roles of zinc finger proteins in neuropsychiatric disorders. We will describe the structure and classification of zinc finger proteins, then focus on the pathophysiological role of zinc finge…
Le fractionnement de la métamémoire dans la maladie d'Alzheimer
2017
Alzheimer's disease is characterized by memory deficits. However, only a few studies have explored how patients judge their memory difficulties. The main aim of this thesis is to determine in more details whether or not Alzheimer’s patients have impaired metamnesic abilities (knowledge about own memory). Indeed, previous studies showed a complex pattern of results and suggested a fractionation of metamemory in Alzheimer’s disease (Souchay, 2007). Therefore, the main aim of this thesis is to explore this fractionation in more details and to explore whether it can be observed (1) between long-term memory tasks and short-term memory tasks, (2) according to the type of response (judgment of lea…
EEG Resting-State Functional Networks in Amnestic Mild Cognitive Impairment.
2022
Background. Alzheimer’s cognitive-behavioral syndrome is the result of impaired connectivity between nerve cells, due to misfolded proteins, which accumulate and disrupt specific brain networks. Electroencephalography, because of its excellent temporal resolution, is an optimal approach for assessing the communication between functionally related brain regions. O bjective. To detect and compare EEG resting-state networks (RSNs) in patients with amnesic mild cognitive impairment (aMCI), and healthy elderly (HE). Methods. We recruited 125 aMCI patients and 70 healthy elderly subjects. One hundred and twenty seconds of artifact-free EEG data were selected and compared between patients with aM…
Insulin-nanogels: preliminary study in mouse for the treatment of Alzheimer's disease
2016
A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signalling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer’s disease (AD). Thus, administration of insulin could be a strategy for AD treatment. For this aim we have designed, synthesized and characterized a nanogel system (NG) that has been conjugated to insulin molecules (NG-In) (1) as new therapeutic approach against AD. In our preclinical studies in mice, intraperitoneal injection of fluorescent-labeled NG has allowed to determine the biodistribution of NG vs time in the whole body and its clearance through the kidneys and bladder. Furthermore, we have observed that mic…
Well-defined polyglutamates as carriers for the treatment of neurodegenerative diseases
2015
Alzheimer’s disease (AD) is a neurodegenerative multiple process of the central nervous system, which currently represents the most common cost of Dementia. The already high incidence of AD is predicted to dramatically increase over the years. In fact, the experts claim that it will become a global epidemy by 2050. Consequently, direct and indirect costs related to AD are doomed to dramatically increase. For instance, only in America, AD related burden will overcome the trillion of dollars by 2050. Moreover, available medication (Exelon®, Namenda®, Aricept®, and Razadyne®) produce moderate symptomatic benefits, but do not stop disease progression. Hence, AD, among other neurodegenerative di…
Copper(II) and zinc(II) interaction with abeta42: effects of metal binding on peptide's aggregation rate and morphology of the aggregates
2011
La funcionalidad de la amígdala en diferentes estados temporales durante el proceso de la patología asociada a la Enfermedad de Alzheimer
2021
La Enfermedad de Alzheimer (EA) es el tipo de demencia más común a nivel mundial. Su aumento está relacionado con la esperanza de vida y el envejecimiento del adulto mayor. Esta enfermedad es una enfermedad neurodegenerativa .La sintomatología de la enfermedad a nivel clínico se caracteriza primeramente por la pérdida de la memoria, la atención, concentración, orientación y el lenguaje, tanto hablado como escrito, pues a medida que avanza la enfermedad se ha observado un declive en áreas del cerebro relacionadas con estas funciones, como se ha visto en diferentes estudios (H. Braak & Braak, 1991).Las áreas más afectadas que podemos destacar son: el hipocampo, la amígdala y la neurocorteza. …