Search results for "Alzheimer"

Muistihäiriöpotilaat liikenteessä: kognitiiviset muutokset ja niiden tiedostaminen

2005

Expériences croisées face à l’épreuve de la maladie d’Alzheimer. Quand personnes malades et proches dessinent des trajectoires d’accompagnement contr…

2018

Cadre de recherche : La littérature consacrée aux familles des personnes malades d’Alzheimer met en lumière la charge que peut représenter l’accompagnement d’une personne malade, mais aussi la diversité des expériences vécues par les proches. Malgré l’abondance de littérature, deux limites sont constatées : ces travaux se fondent strictement sur le discours des proches et ils appréhendent l’expérience de l’accompagnement sur la base d’une approche synchronique.Objectifs : Cet article a l’ambition de dépasser ces deux limites en mettant en dialogue, dans la durée, les témoignages des personnes malades d’Alzheimer et de leurs proches. Nous proposons d’analyser ce qui se joue dans les dynamiqu…

Alzheimer's disease: new diagnostic and therapeutic tools.

2008

Abstract On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related diseases was held in Palermo, Italy. Here, the lectures of M. Racchi on History and future perspectives of Alzheimer Biomarkers and of G. Scapagnini on Cellular Stress Response and Brain Ageing are summarized. Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease, which in Western society mainly accounts for clinica dementia. AD prevention is an important goal of ongoing research. Two objectives must be accomplished to make prevention feasible: i) individuals at high risk of AD need to be identified before the earliest symptoms become evident, by which time extensive neurodege…

Pathophysiology of vascular dementia.

2009

The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.Conventional definitions identify the patients too late, miss subjects with cognitive impairment short of dementia, and emphasize consequences rather than causes, the true bases for treatment and prevention. We should throw out current diagnostic categories and describe cognitive impairment clinically and according to commonly agreed instruments that document the demographic data in a standardized manner and undertake a systematic effort to identify the underlying aetiology in each case.Increased effort should be targeted towards the concept of and criteri…

Linguistic impairments in subjects with dementia of the alzheimer’s type: status of the issue

2012

Las personas con demencia de tipo alzhéimer sufren alteraciones lingüísticas. Se han llevado a cabo algunos estudios que describen la naturaleza de este déficit. Los resultados de estos trabajos demuestran que los componentes léxico-semántico y pragmático se encuentran mucho más deteriorados que los niveles fonético-fonológico y morfosintáctico del lenguaje. Nuestro propósito es elaborar un breve estado de la cuestión que nos permita tener una perspectiva global sobre el proceso de deterioro comunicativo. Además, enfatizamos la importancia del análisis lingüístico a la hora de diagnosticar la enfermedad de Alzheimer, ya que se pueden encontrar cambios en las habilidades discursivas desde la…

Selection of Membrane RNA Aptamers to Amyloid Beta Peptide: Implications for Exosome-Based Antioxidant Strategies

2019

The distribution of amyloid beta peptide 42 (Aβ42) between model exosomal membranes and a buffer solution was measured. The model membranes contained liquid-ordered regions or phosphatidylserine. Results demonstrated that up to ca. 20% of amyloid peptide, generated in the plasma (or intracellular) membrane as a result of proteolytic cleavage of amyloid precursor proteins by β- and γ-secretases, can stay within the membrane milieu. The selection of RNA aptamers that bind to Aβ42 incorporated into phosphatidylserine-containing liposomal membranes was performed using the selection-amplification (SELEX) method. After eight selection cycles, the pool of RNA aptamers was isol…

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

2001

Biochemical, epidemiological, and genetic findings demonstrate a link between cholesterol levels, processing of the amyloid precursor protein (APP), and Alzheimer's disease. In the present report, we identify the α-secretase ADAM 10 ( a d isintegrin a nd m etalloprotease) as a major target of the cholesterol effects on APP metabolism. Treatment of various peripheral and neural cell lines with either the cholesterol-extracting agent methyl-β-cyclodextrin or the hydroxymethyl glutaryl-CoA reductase inhibitor lovastatin resulted in a drastic increase of secreted α-secretase cleaved soluble APP. This strong stimulatory effect was in the range obtained with phorbol esters and was further increa…

Music as a mnemonic to learn gesture sequences in normal aging and Alzheimer’s disease

2014

Strong links between music and motor functions suggest that music could represent an interesting aid for motor learning. The present study aims for the first time to test the potential of music to assist in the learning of sequences of gestures in normal and pathological aging. Participants with mild Alzheimer's disease (AD) and healthy older adults (Controls) learned sequences of meaningless gestures that were either accompanied by music or a metronome. We also manipulated the learning procedure such that participants had to imitate the gestures to-be-memorized in synchrony with the experimenter or after the experimenter during encoding. Results show different patterns of performance for t…

Cerebrospinal Fluid Tau Protein Levels and <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography in the Differential Diagnosis o…

2010

<i>Aims:</i> In this study, we aimed to compare cerebrospinal fluid (CSF) levels of total tau (t-tau), phosphorylated tau (p-tau<sub>181</sub>) and positron emission tomography with <sup>18</sup>F-fluorodeoxyglucose (FDG-PET) in the differential diagnosis of Alzheimer’s disease (AD) under clinical conditions. <i>Method:</i> In a cross-sectional, blinded, single-center study, we examined a sample of 75 unselected memory clinic patients with clinical diagnoses of dementia of Alzheimer type (DAT; n = 24), amnestic mild cognitive impairment (MCI; n = 16), other dementias (n = 13) and nondemented controls (n = 22). Discriminative accuracy, sensitiv…

Potential drug-drug interaction between duloxetine and acenocoumarol in a patient with Alzheimer's disease

2007

Abstract Background : Recent evidence suggests that duloxetine may increase the effect of warfarin, thereby increasing the possibility of bleeding. However, a MEDLINE search for articles published between 1980 and May 2007 (terms: duloxetine , anticoagulants , acenocoumarol , and interaction ; no language restriction) did not yield any reports of an interaction between concomitant use of duloxetine and acenocoumarol. Objective : The aim of this study was to describe a potential drug-drug interaction between duloxetine and acenocoumarol in a patient with Alzheimer's disease. The possible mechanism of this potential interaction is examined. Case summary : This report presents the case of a 63…