Search results for "Amifampridine"

showing 3 items of 3 documents

Five years experience on 3,4-diaminopyridine phosphate in Lambert-Eaton syndrome: Case reports

2017

Abstract Rationale: To report our experience on 7 patients (4 males and 3 females), affected by nonparaneoplastic Lambert–Eaton myasthenic syndrome, treated with 3,4-diaminopyridine phosphate (3,4-DAPP) either alone or in combination with other immunosuppressants or steroids. Patient concerns: Patients have been evaluated at specific timepoints (ie, baseline and last 5 year follow-up), with neurological examination, autoantibodies against presynaptic voltage-gated Cav2.1 (P/Q type) calcium ion channel (VGCC) dosage, neurophysiological evaluation focusing on the increased amplitude of the compound muscle action potential (cMAP) after maximum voluntary effort, quantitative myasthenia gravis (…

AdultMalemedicine.medical_specialtyAzathioprineNeurological examination030204 cardiovascular system & hematologySeverity of Illness Index5300nonparaneoplastic-Lambert–Eaton myasthenic syndrome03 medical and health sciences0302 clinical medicinePrednisoneInternal medicineSeverity of illnessActivities of Daily LivingAzathioprinemedicineHumansMuscle StrengthClinical Case Report4-AminopyridineAdverse effect34-diaminopyridine phosphate; nonparaneoplastic-Lambert-Eaton myasthenic syndrome; 4-Aminopyridine; Activities of Daily Living; Adult; Azathioprine; Drug Therapy Combination; Female; Humans; Immunosuppressive Agents; Lambert-Eaton Myasthenic Syndrome; Male; Middle Aged; Muscle Strength; Prednisone; Severity of Illness Index; Treatment Outcome; Medicine (all)medicine.diagnostic_testbusiness.industry34-diaminopyridine phosphateGeneral MedicineMiddle Agedmedicine.diseaseMyasthenia gravisLambert-Eaton Myasthenic SyndromeTreatment OutcomeConcomitantPrednisoneDrug Therapy CombinationFemaleAmifampridinebusinessLambert-Eaton myasthenic syndrome030217 neurology & neurosurgeryImmunosuppressive Agentsmedicine.drugResearch Article
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Cognitive deficits in aged rats correlate with levels of l-arginine, not with nNOS expression or 3,4-DAP-evoked transmitter release in the frontopari…

2005

Aging is associated with altered neurotransmitter function in the brain. In this study, we measured release parameters for acetylcholine (ACh), norepinephrine and serotonin in the frontoparietal cortex of young and aged rats. We also determined cortical amino acid concentrations and nitric oxide (NO) synthase function. Prior to sacrifice, the rats had been tested for Morris water-maze performance. In aged, compared with young rats, we observed a reduction in both uptake of choline and acetylcholine release. Serotonin release and L-arginine concentrations (a precursor of NO) showed an aging-related increase; however, L-citrulline/L-arginine ratios were decreased in aged rats. Moreover, while…

AgingSerotoninmedicine.medical_specialtyArginineNerve Tissue ProteinsNitric Oxide Synthase Type IArginineNitric oxideNorepinephrinechemistry.chemical_compoundNeurochemicalParietal LobeInternal medicineCortex (anatomy)medicineAnimalsCholineRats Long-EvansPharmacology (medical)4-AminopyridineNeurotransmitterBiological PsychiatryCerebral CortexPharmacologyNeurotransmitter AgentsAcetylcholineFrontal LobeRatsPsychiatry and Mental healthEndocrinologymedicine.anatomical_structureGene Expression RegulationNeurologychemistryFemaleNeurology (clinical)SerotoninAmifampridineNitric Oxide SynthaseCognition DisordersAcetylcholinemedicine.drugEuropean Neuropsychopharmacology
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Differential effects of potassium channel blockers on neurohypophysial release of oxytocin and vasopressin. Evidence for frequency-dependent interact…

1988

Isolated rat neurohypophyses were fixed by their stalks to a platinum wire electrode and superfused with Krebs-HEPES solution. Vasopressin and oxytocin released into the medium were determined by specific radioimmunoassays. Hormone secretion was increased by electrical stimulation of the pituitary stalk at different frequencies. The effects of several potassium channel blockers, tetraethylammonium (TEA) ions, 4-aminopyridine (4-AP) and 3,4-diaminopyridine (3,4-DAP) were tested. The release of vasopressin and oxytocin evoked by electrical stimulation with 900 pulses at 15 Hz (about 900 and 1,000 μU, respectively) was about 10 times higher than that evoked by 900 pulses at 3 Hz. Both 10 and 3…

medicine.medical_specialtyVasopressinCromakalimPotassium ChannelsVasopressinsRadioimmunoassayNeuropeptideAminopyridinesStimulation(+)-NaloxoneOxytocinPituitary Gland PosteriorInternal medicinemedicineAnimalsBenzopyransPyrroles4-AminopyridineEndogenous opioidPharmacologyChemistryNaloxoneTetraethylammoniumPotassium channel blockerRats Inbred StrainsGeneral MedicineTetraethylammonium CompoundsPotassium channelElectric StimulationRatsEndocrinologyOxytocinFemaleEndorphinsAmifampridinehormones hormone substitutes and hormone antagonistsmedicine.drugNaunyn-Schmiedeberg's archives of pharmacology
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