Search results for "Aminosteroid"

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Asymmetric Allylation/Pauson-Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues

2014

Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

Molecular StructureChemistrymedicine.medical_treatmentPauson–Khand reactionOrganic ChemistrySonogashira couplingStereoisomerismBiochemistrySteroidComputational chemistrySimple (abstract algebra)CyclizationIntramolecular forcemedicineSteroidsPhysical and Theoretical ChemistryAminesAminosteroidmedicine.drug
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ChemInform Abstract: Asymmetric Allylation/Pauson-Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid A…

2014

Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson–Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

Chemistrymedicine.medical_treatmentIntramolecular forcePauson–Khand reactionmedicineSonogashira couplingGeneral MedicineCombinatorial chemistryAminosteroidmedicine.drugSteroidChemInform
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