Search results for "Amorphous solid"
showing 10 items of 622 documents
Development and Characterization of an Amorphous Solid Dispersion of Furosemide in the Form of a Sublingual Bioadhesive Film to Enhance Bioavailabili…
2017
Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability problems, reported as a consequence of an erratic gastrointestinal absorption due to various existing polymorphic forms and low and pH-dependent solubility. A mucoadhesive sublingual fast-dissolving FUR based film has been developed and evaluated in order to optimize the bioavailability of FUR by increasing solubility and guaranteeing a good dissolution reproducibility. The Differential Scanning Calorimetry (DSC) analyses confirmed that the film prepared using the solvent casting method entrapped FUR in the amorphous state. As a solid dispersion, FUR increa…
Photochemical generation of E′ centres from Si–H in amorphous SiO2under pulsed ultraviolet laser radiation
2006
In situ optical absorption spectroscopy was used to study the generation of E' centres () in amorphous SiO2 occurring by photo-induced breaking of Si–H groups under 4.7 eV pulsed laser radiation. The dependence on laser intensity of the defect generation rate is consistent with a two-photon mechanism for Si–H rupture, while the growth and saturation of the defects are conditioned by their concurrent annealing due to a reaction with mobile hydrogen arising from the same precursor. A rate equation is proposed to model the kinetics of the defects and is tested on experimental data.
Effects of high pressure thermal treatments in oxygen and helium atmospheres on amorphous silicon dioxide and its radiation hardness
2009
The effects of thermal treatments at similar to 400 degrees C in oxygen or helium atmospheres at similar to 180 baron the radiation hardness of amorphous SiO(2) are studied. The generation efficiency of several point defects under gamma irradiation is compared to that of the untreated material. All the effects on point defects generation here observed can be explained in terms of changes in the precursor sites. In particular it has been observed that the thermal treatments can change the precursors sites of point defects both through temperature and pressure related processes, not depending on the atmosphere, and through oxygen related processes creating oxygen excess sites. The presence of…
In-situ observation of beta-ray induced UV optical absorption in a-SiO2: radiation darkening and room temperature recovery
2006
International audience; We studied the optical absorption in the 3.0-6.2 eV range induced in bulk amorphous SiO2 by beta-ray irradiation up to similar to 1 MGy at room temperature. The induced absorption was measured in situ both during irradiation and in the post irradiation time. Our data evidence E', center as the main defect induced by irradiation and the partial decay of their absorption band at about 5.8 eV after irradiation. A quantitative analysis of the time evolution of the induced absorption shows that the transmission recovery observed after irradiation is compatible with the reaction of radiation-induced defects with H-related (H-2, H2O) species diffusing in the amorphous matrix
ChemInform Abstract: High-Resolution Solid-State NMR Spectroscopy of Steroids and Their Derivatives
2013
Abstract: Steroids are an important class of organic compounds containing a vast array of biologically and physiologically essential molecules. Due to their availability, relatively straightforward derivatizability, and endogeneity, they are widely used in pharmacological applications. The investigation of molecular and physicochemical properties of active pharmaceutical ingredients (APIs) in the solid state is important, because these properties are directly related to their pharmacological activity. Several methods are available for this purpose. Solid-state NMR spectroscopy offers a nondestructive and flexible technique, providing both structural and dynamic information. It can be applie…
High-Resolution Solid-State NMR Spectroscopy of Steroids and Their Derivatives
2013
Abstract: Steroids are an important class of organic compounds containing a vast array of biologically and physiologically essential molecules. Due to their availability, relatively straightforward derivatizability, and endogeneity, they are widely used in pharmacological applications. The investigation of molecular and physicochemical properties of active pharmaceutical ingredients (APIs) in the solid state is important, because these properties are directly related to their pharmacological activity. Several methods are available for this purpose. Solid-state NMR spectroscopy offers a nondestructive and flexible technique, providing both structural and dynamic information. It can be applie…
Physicochemical characterization of passive films on niobium by admittance and electrochemical impedance spectroscopy studies
2005
An analysis of the electronic properties of amorphous semiconductor-electrolyte junction is reported for thin (D ox < 20 nm) passive film grown on Nb in acidic electrolyte. It will be shown that the theory of amorphous semiconductor-electrolyte junction (a-SC/EI) both in the low band-bending and high band-bending regime is able to explain the admittance data of a-Nb 2 O 5 /El interface in a large range (10 Hz-10 kHz) of frequency and electrode potential values. A modelling of experimental EIS data at different potentials and in the frequency range of 0.1 Hz-100 kHz is presented based on the theory of amorphous semiconductor and compared with the results of the fitting of the admittance data…
Effect of NiO and/or TiO2 mullite formation and microstructure from gels
1998
Polymeric and colloidal gels with a constant molar ratio of (Al+Ni and/or Ti)/Si=3/1 and various (Al/Ni and/or Ti) ratios (up to 21.42 mol% NiO+TiO2) were prepared and used to study the effect of the precursor chemical homogeneity on mullite formation processes and the resulting microstructure. Both kinds of gel precursors were preheated at 750°C for 3 h in order to obtain appropriate gel-derived glasses for further thermal processing. After annealing for several time periods at temperatures between 750 and 1500°C, differences in crystallization pathways were observed. Polymeric gels crystallized Al–Si and NiAl2O4 spinels from the amorphous form at temperatures in the range between 900 and …
Magnetic and structural study of (Fe1−Co )62 Nb8B30 bulk amorphous alloys
2004
Abstract The electric and magnetic properties of rapidly quenched (Fe 1− x Co x ) 62 Nb 8 B 30 bulk metallic glasses were studied with x =0, 0.33 and 0.50. The Curie temperature in the amorphous state was found to be about 245 °C for the Co-free alloy, 290 °C for x =0.33 and 201 °C for x =0.50, while the crystallization temperature is varying within 15° only around 600 °C. The change in T C correlates with the change in Mossbauer parameters. An interesting flattening effect of annealing on the hysteresis loop was observed which increases with the Co content. The resistivity could not be improved above 152 μΩ cm, which limits the high frequency applications of these alloys.
Electrical resistivity of amorphous simple metals at moderately low temperatures
1999
Abstract The dependence of electrical resistivity ρ ( T ) on temperature T in a region of moderate temperatures is considered for amorphous simple metals. It is shown within the Faber–Ziman theory that the ratio [ ρ ( T )− ρ (0)]/ T 2 has a maximum in the temperature region 10 K⩽ T ⩽100 K The theory is illustrated by numerical calculations performed for hard-sphere models of amorphous Mg and Zn.