Search results for "Analyse"

showing 10 items of 1155 documents

Analysis of thiamine transporter genes in sporadic beriberi

2014

Abstract Objective Thiamine or vitamin B 1 deficiency diminishes thiamine-dependent enzymatic activity, alters mitochondrial function, impairs oxidative metabolism, and causes selective neuronal death. We analyzed for the first time, the role of all known mutations within three specific thiamine carrier genes, SLC19 A2, SLC19 A3 , and SLC25 A19 , in a patient with atrophic beriberi, a multiorgan nutritional disease caused by thiamine deficiency. Methods A 44-year-old male alcoholic patient from Morocco developed massive bilateral leg edema, a subacute sensorimotor neuropathy, and incontinence. Despite normal vitamin B 1 serum levels, his clinical picture was rapidly reverted by high-dose in…

AdultMalemedicine.medical_specialtySLC19 A- SLC25 A19SLC19 AEndocrinology Diabetes and MetabolismGene mutationBeriberimedicine.disease_causeMitochondrial Membrane Transport Proteinslaw.inventionBeriberilawInternal medicineGenotypemedicineThiamine transporterObjective: Thiamine or vitamin B1 deficiency diminishes thiamine-dependent enzymatic activity alters mitochondrial function impairs oxidative metabolism and causes selective neuronal death. We analyzed for the first time the role of all known mutations within three specific thiamine carrier genes SLC19 A2 SLC19 A3 and SLC25 A19 in a patient with atrophic beriberi a multiorgan nutritional disease caused by thiamine deficiency. Methods: A 44-year-old male alcoholic patient from Morocco developed massive bilateral leg edema a subacute sensorimotor neuropathy and incontinence. Despite normal vitamin B1 serum levels his clinical picture was rapidly reverted by high-dose intramuscular thiamine treatment suggesting a possible genetic resistance. We used polymerase chain reaction followed by amplicon sequencing to study all the known thiamine-related gene mutations identified within the Human Gene Mutation Database. Results: Thirty-seven mutations were tested: 29 in SLC19 A2 6 in SLC19 A3 and 2 in SLC25 A19. Mutational analyses showed a wild-type genotype for all sequences investigated. Conclusion: This is the first genetic study in beriberi disease. We did not detect any known mutation in any of the three genes in a sporadic dry beriberi patient. We cannot exclude a role for other known or unknown mutations in the same genes or in other thiamine-associated genes in the occurrence of this nutritional neuropathy.HumansThiamineGenePolymerase chain reactionGeneticsMutationNutrition and DieteticsbiologyMembrane Transport ProteinsThiamine Deficiencymedicine.diseaseAlcoholismEndocrinologyMutationbiology.proteinThiamineMutations
researchProduct

Teaching swimming at primary school level : a significant difficulty for the subject

2020

This thesis seeks to identify and understand, from the epistemological and methodological field of psychoanalysis, the nature of the difficulty in teaching swimming encountered by four P.E. primary school teachers. It is based on a trainer’s observation witnessing the embarrassment of P.E. teachers confronted with this discipline and with a lack of ‘solutions’ to deal successfully with this professional difficulty. The clinical methodological device consists in the construction of four cases based on the interpretative analysis of the subject’s speech, collected through individual clinical interviews. This collection is completed by a clinical observation time during teaching sessions for t…

AffectPsychanalyseTeachingNatation[SHS.EDU] Humanities and Social Sciences/EducationswimmingAnxietyEnseignementRapport au savoirDifficultyDifficultéPsychoanalysisRelation to knowledge
researchProduct

Montagnes d’Afrique tropicale : marqueurs de la variabilité climatique ou isolats climatiques ?

2011

6 pages; International audience; Les montagnes tropicales sont souvent perçues comme des sentinelles des changements climatiques. Pour autantles variations climatiques interannuelles à décennales sont-elles le reflet de celles des espaces environnants ? A l’échelle del’Afrique au sud du Sahara, une analyse de la variabilité des pluies entre 1941 et 2000 montre une cohérence spatiale peudiminuée par les reliefs. Des exemples sont présentés de reliefs constituant même des révélateurs de la dynamiqueatmosphérique et de la variabilité climatique d’échelles larges.

Afrique tropicale[SDU.STU.CL] Sciences of the Universe [physics]/Earth Sciences/Climatology[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/ClimatologyVariabilité climatiqueprécipitationsrelief[ SDU.STU.CL ] Sciences of the Universe [physics]/Earth Sciences/Climatologyanalyse spatiale
researchProduct

Etude diagnostique de nouvelles données climatiques : les réanalyses. Exemples d'application aux précipitations en Afrique tropicale

2000

This study establishes an objective diagnosis of NCEP/NCAR reanalysis data reliability over tropical Africa at intra-seasonal to interannuel space scale. The reanalysis data are an original database available over 1958-1998 period which combines observations and atmospheric model outputs and allows us to better understand global scale atmospheric dynamics. The study of data reliability allows us to identify a great number of recommendations for using them. Over tropical Africa, the homogeneous period which should be extracted goes from 1968 to 1998. Before this year, reanalysed datasets should be used with greatest caution. However, during this period, the SMWDA, a statistical method used t…

Afrique tropicaleteleconnectiontropical Africa[SHS.GEO] Humanities and Social Sciences/Geographyrainfall[SHS.GEO]Humanities and Social Sciences/Geography[ SHS.GEO ] Humanities and Social Sciences/Geography<br /> téléconnexionstest of reliability[SDU.STU.CL] Sciences of the Universe [physics]/Earth Sciences/ClimatologyNCEP/NCAR Reanalysis[SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatologycirculation divergente de l'atmosphèreprécipitationsréanalyses du NCEP/NCAR[ SDU.STU.CL ] Sciences of the Universe [physics]/Earth Sciences/Climatologydivergent circulation of atmospheretest <br /> de fiabilité
researchProduct

Nouvelles formes d'analyse et d'intervention de la Banque mondiale en Afrique sub-saharienne dans le domaine de l'éducation

2001

International audience

AfriqueBanque mondiale[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationÉducationInterventionAnalyseSystème éducatifAfrique subsaharienneComputingMilieux_MISCELLANEOUS
researchProduct

Analyse des coûts de l'enseignement primaire télévisuel en Côte d'Ivoire

1980

International audience

AfriqueCote d'IvoireTechnologie de l'éducation[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationComputingMilieux_MISCELLANEOUSAnalyse de coûtEnseignement primaire
researchProduct

Towards a Better Understanding of the Functioning of School Systems for Better Decision Making : The Case of Primary Schools in Togo

1991

International audience

AfriqueEfficacité de l'enseignementPrise de décisionTogo[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationAméliorationFonctionnement du système éducatifAnalyseComputingMilieux_MISCELLANEOUSEnseignement primaire
researchProduct

L'analyse des coûts et du financement de l'éducation au Sénégal

1985

référence interne : 85034

AfriqueFinancement de l'éducationSénégal[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationAnalyse de coût
researchProduct

Analyse des coûts et du financement de l'éducation au Mali

1985

référence interne : 85039

AfriqueFinancement de l'éducation[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationMaliAnalyse de coût
researchProduct

The cost-effectiveness of mass media for agricultural extension in Malawi

1983

Ouvrage disponible sur : http://documents1.worldbank.org/curated/en/999271468770338179/pdf/multi-page.pdf; International audience; This paper reports the results of research concerning the role of massmedia in providing information to Malawian farmers. To set the context, the paper begins with a brief description of the face-to-face information services provided by the agricultural extension system and by the farmer training centers; it then describes in more detail the operations of the Extension Aids Branch (EAB) of the Ministry of Agriculture. EAB prepares and delivers messages to farmers using radio, print, and mobile vans(carrying films for night-time use and puppet shows for daytime u…

AfriqueMalawiMediaCulture de masse[SHS.EDU]Humanities and Social Sciences/Education[SHS.EDU] Humanities and Social Sciences/EducationAnalyse coût-efficacitéDéveloppement agricole
researchProduct