Search results for "Analysis method"
showing 3 items of 713 documents
Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane
2021
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …
Flexible and Efficient Computer-Aided Design Tool for Advanced Comb-Line Rectangular Waveguide Filters
2015
A very flexible and efficient computer-aided design (CAD) tool, specifically suited for advanced comb-line rectangular waveguide filters, is presented in this work. The developed software tool, which makes use of a full-wave analysis technique based on the Boundary Integral - Resonant Mode Expansion method, permits to load the considered comb-line resonators with any number of radially symmetrical partial-height metallic posts. The implemented CAD tool also allows for dealing with coupling windows of arbitrary cross-section, thus drastically enhancing the flexibility of the computer-aided design process. The excitation of the analyzed components, which is performed by using generalized coax…
XENON1T Dark Matter Data Analysis: Signal Reconstruction, Calibration and Event Selection
2019
The XENON1T experiment at the Laboratori Nazionali del Gran Sasso is the most sensitive direct detection experiment for dark matter in the form of weakly interacting particles (WIMPs) with masses above $6\,$GeV/$c^2$ scattering off nuclei. The detector employs a dual-phase time projection chamber with 2.0 metric tons of liquid xenon in the target. A one metric $\mathrm{ton}\times\mathrm{year}$ exposure of science data was collected between October 2016 and February 2018. This article reports on the performance of the detector during this period and describes details of the data analysis that led to the most stringent exclusion limits on various WIMP-nucleon interaction models to date. In pa…