Search results for "Anemia"

Autoimmune Hemolytic Anemia and Human Immunodeficiency Virus (HIV) Infection

1988

Excerpt To the editor:In patients with human immunodeficiency virus (HIV) infection, normochromic-normocytic anemia is common (1). Only four cases of autoimmune hemolytic anemia have been reported ...

Adaptive treatment of anemia on hemodialysis patients: A reinforcement learning approach

2011

The aim of this work is to study the applicability of reinforcement learning methods to design adaptive treatment strategies that optimize, in the long-term, the dosage of erythropoiesis-stimulating agents (ESAs) in the management of anemia in patients undergoing hemodialysis. Adaptive treatment strategies are recently emerging as a new paradigm for the treatment and long-term management of the chronic disease. Reinforcement Learning (RL) can be useful to extract such strategies from clinical data, taking into account delayed effects and without requiring any mathematical model. In this work, we focus on the so-called Fitted Q Iteration algorithm, a RL approach that deals with the data very…

Hemoglobin point-of-care testing: the HemoCue system.

2013

Besides the use of traditional laboratory resources, the diagnosis of anemia can also be accomplished by assessing hemoglobin (Hb) concentration with point-of-care testing (POCT) devices such as the HemoCue test systems. In several situations, these devices might suitably replace traditional laboratory testing, including several areas of health care where a very rapid Hb measurement might be required to make immediate therapeutic decisions. The use of these devices, however, should fulfill some basic criteria, including economic, clinical, and regulatory issues; appropriate training of the users and knowledge of test requirements, performance, limitations, and potential interferences; the u…

Glucose 6-phosphate dehydrogenase Palermo R257M: a novel variant associated with chronic non-spherocytic haemolytic anaemia

2010

Increased susceptibility of microcytic red blood cells to in vitro oxidative stress.

1995

Oxidative damage to erythrocytes in thalassaemia has been related to generation of free radicals by an excess of denaturated alpha- or beta-globin chains, intracellular iron overload and low concentration of normal haemoglobin (HGB). Two good indicators of such oxidative damage are the high red blood cell (RBC) malonyldialdehyde (MDA) production detected following exogenous oxidant stress and the decrease of pyrimidine 5'-nucleotidase (P5N), the most sensitive enzyme to SH-group damage in vivo. Conflicting data, however, have so far accumulated in the literature concerning differences in oxidative damage between the different forms of thalassaemia and iron deficiency anaemia (IDA). In the p…

Transfusion Therapy in a Multi-Ethnic Sickle Cell Population Real-World Practice. a Preliminary Data Analysis of Multicentre Survey

2018

Abstract Introduction. Despite the increasing of number of patients with Sickle Cell Disease (SCD) in Italy, due to multi-ethnic migratory phenomena, a large percentage of Caucasian sickle population is already present in Italy mainly with b-thal/HbS genotype. Red cell transfusion is one effective treatment for both acute and chronic complications of SCD, while hydroxycarbamide (HC) is used to reduce the frequency of painful vaso-occlusive crises (VOCs) and decrease the need for blood transfusion. Through the National Comprehensive Reference Centers for SCD, the Italian Society of Thalassemia and Hemoglobinopathies (SITE), in collaboration with the Society Italian Transfusion Medicine and I…

Geographical Disparities in Multiple Myeloma Survival in Three French Regions

2016

Abstract Introduction: Within the past decade, new therapeutic agents for Multiple Myeloma (MM) have improved survival of patients included in clinical trials. The aim of this study was to measure and compare characteristics and survival of patients with MM in different French regions in the general population. Methods: All incident cases with MM (ICD-O-3 codes, 9732/3 and) between January 1, 2008 and December 31, 2009 in the French population-based Hematological Malignancies registries (Calvados, Côte d'Or and Gironde) were included. The end point of follow-up was January 1, 2015. Specific clinical information was recorded from clinical charts. Incidence rates were calculated using estimat…

Subcutaneous recombinant human erythropoietin prevents chemotherapy-related anemia in patients with advanced cancer.

1992

Influencia del tiempo de ligadura del cordón umbilical en la morbilidad secundaria neonatal y los depósitos de hierro en el neonato

2022

El déficit de hierro es el déficit nutricional más frecuente a nivel mundial y constituye un importante problema de salud pública, principalmente en los países más desfavorecidos. La causa más frecuente de anemia en el mundo es la deficiencia de hierro. Los períodos críticos donde los requerimientos son elevados son el primer año de vida, la adolescencia y el embarazo. El pinzamiento demorado aumenta los depósitos de hierro en los RN, que les garantiza una disponibilidad de este mineral durante los primeros meses de vida, periodo crucial del desarrollo de múltiples sistemas como el SNC. , pero también se le se asoció con un aumento de la policitemia neonatal, ictericia patológica con necesi…

Myelotoxicity from cytostatic treatment, an important risk factor in the management of neoplasias in the elderly

2006

Myelotoxicity is the most common complication of cancer chemotherapy. A brief review of hematopoiesis is necessary to understand the mechanisms of myelotoxicity and the treatment strategies that may minimize this complication in elderly patients. From this review of hematopoiesis and age, we may draw three conclusions: aging is associated with a progressive reduction in hematopoietic reserve; by itself, the decline in hematopoietic reserve does not produce abnormalities of the circulating blood, these may occur as a consequence of hematopoietic stress; hematopoietic growth factors are effective in promoting granulopoiesis and erythropoiesis in older individuals. Alternative strategies inclu…