Search results for "Animal"
showing 10 items of 22159 documents
Is it possible to understand a book missing a quarter of the letters? Unveiling the belowground species richness of grasslands
2022
Abstract Knowledge of species richness patterns in plant communities is biased toward its hidden belowground part and is derived only from the part visible aboveground. Studies on the relationship of the above- to belowground parts of plant communities suffer from the lack of a consistent and uniform approach to assess their taxonomic composition, particularly in species-rich ecosystems. This study described the proportion between above- and belowground parts of vegetation in three grassland types along with the environmental factors that affect them, using eDNA metabarcoding and an observer survey. The internal transcribed spacer 2 (ITS2) region was used to analyze the total plant richness…
Relationship between inbreeding and milk production traits in two Italian dairy sheep breeds.
2022
The effects of inbreeding in livestock species breeds have been well documented and they have a negative impact on profitability. The objective of this study was to evaluate the levels of inbreeding in Sarda (SAR, n = 785) and Valle del Belice (VdB, n = 473) dairy sheep breeds and their impact on milk production traits. Two inbreeding coefficients (F) were estimated: using pedigree (FPED), or runs of homozygosity (ROH; FROH) at different minimum ROH lengths and different ROH classes. After the quality control, 38,779 single nucleotide polymorphisms remained for further analyses. A mixed-linear model was used to evaluate the impact of inbreeding coefficients on production traits within each …
Analysis of runs of homozygosity of cattle living in different climate zones
2023
Abstract Aim of this study was to analyze the distribution and characteristics of runs of homozygosity in Bos taurus taurus and Bos taurus indicus breeds, as well as their crosses, farmed all around the world. With this aim in view, we used single-nucleotide polymorphisms (SNP) genotypes for 3,263 cattle belonging to 204 different breeds. After quality control, 23,311 SNPs were retained for the analysis. Animals were divided into seven different groups: 1) continental taurus, 2) temperate taurus, 3) temperate indicus, 4) temperate composite, 5) tropical taurus, 6) tropical indicus, and 7) tropical composite. The climatic zones were created according to the latitude of the breeds’ country of…
Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
2020
Funding: Transgène; International audience; Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs. Cohort and pre-clinical studies have established the link between a functional T-cell-mounted immunity and resolution of infection. TG1050 is an adenovirus 5-based vaccine that expresses HBV polymerase and domains of core and surface antigen and has shown immunogenicity and antiviral effects in mice. We performed a phase 1 clinical trial to assess safety and explore immunogenicity and early efficacy of TG1050 in CHB patients. This randomized, double blind, placebo-controlled study included two sequential phases: one single dose cohort (SD, n = 12) and one …
Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging
2011
Objective To determine whether pulsed Doppler examination of the ductus venosus in rat fetuses could damage exposed tissue. Methods On gestational day 18, the livers of a mean of approximately five fetuses per mother (n = 5.14, SD = 1.6), in a cohort of 35 pregnant female rats, were exposed individually to pulsed Doppler and these were considered the 'exposed group'. The remaining fetuses in each pregnant rat (n = 5.16, SD = 2.1) formed the 'control group'. We tested for 600, 300, 60, 20, 15, 10 and 3 s of exposure of the fetal ductus venosus and the damage was evaluated measuring a cell death index of apoptotic activity at 7 h post-exposure (n = 16). In addition, subgroups of mothers were …
Tenapanor for the treatment of irritable bowel syndrome with constipation.
2020
Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …
Bean goose migration shows a long-term temporal shift to earlier spring, but not to later autumn migration in Finland
2023
Ilmastonmuutos vaatii eliöitä mukauttamaan perinnöllisiä tai opittuja käyttäytymismallejaan muuttuviin ympäristöolosuhteisiin. Erityisen alttiita muutoksille voi olla erilaisten habitaattien välillä muuttavat linnut, joiden selviytyminen on yhteydessä muuton onnistuneeseen ajoittamiseen. Tässä tutkimuksessa käytimme metsähanhesta (Anser fabalis) avoimeen lintutietopalveluun, Tiiraan (tiira.fi – BirdLife Suomi), kerättyjä havaintoja selvittääksemme, onko lajin muuton ajoituksessa tapahtunut muutosta viimeisten 40 vuoden aikana. Lisäksi selvitimme ajoituksen yhteyttä muuton aikaiseen suursäätilaan käyttämällä Pohjois-Atlantin suursäätilaa kuvaavaa NAO-indeksiä. Tutkitulla ajanjaksolla 1978–20…
Incorporación de elementos traza en conchas de melanopsis durante el crecimiento : posibilidades de aplicación en paleoecología
1988
El objetivo del presente trabajo está encaminado al estudio de las variaciones de oligoelementos en la concha de un gasterópodo de agua dulce del género Melanopsis (U dufouri (FERUSSAC), con dos morfotipos) y si éstas tienen que ver, o no, con la fluctuación de una serie de parámetros ambientales. La importancia del trabajo radica en la posibilidad de la aplicación paleoecológica de sus resultados, ya que el género MelanopsÍs tiene un abundante registro fósil durante todo el Cenozoico. La incorporación de oligoelementos se efectúa a medida que la concha va creciendo por acreción; lo ideal sería que tal crecimiento fuera circadiano, ya que se podría seguir día a día, sobre la concha, la fluc…
Vocal communication in the Iberian wolf
2015
PARTE I. COMUNICACIÓN ACÚSTICA EN EL LOBO IBÉRICO El lobo (Canis lupus) es un carnívoro social cuya unidad básica de organización social es la manada, formada básicamente por una pareja reproductora y sus descendientes de varios años (Mech 1970, 1999). El número medio de lobos que integra una manada (tamaño de grupo) oscila entre 3 y 11 individuos (Fuller et al., 2003) y, en condiciones naturales, depende en gran medida de la disponibilidad de alimento (Mech & Boitani, 2003). Uno de los comportamientos más característicos y llamativos de los lobos es la emisión de aullidos para comunicarse a largas distancias. Quizá por este motivo la comunicación acústica de los lobos ha sido objeto de est…
Enonciation animale : Franz Kafka, Primo Levi, le singe et la poule
2018
Cet articleessayera de discuter la question de l’énonciation animale à partir d’une perspective de recherche un peu plus étendue : celle qu’on a appelée d’une zoosemiotique 2.0 : c’est à dire une perspective sémiotique que, en outrepassant les recherches traditionnelles sur le langage et/ou la communication animale (inscrites dans une épistémologie naturaliste et scientiste), peut étudier l’animal ‘en situation’, acteur non-humain qui a des relations sociales (narrative, discursives) avec d’autres acteurs humaines et non humains. Plutôt que présupposer une différence de principe entre homme et animales, il faudrait donc rétablir les dispositifs sémiotiques à partir desquels ils se construis…