Search results for "Animal"
showing 10 items of 22159 documents
Sisubiotus hakaiensis sp. nov. (Tardigrada, Macrobiotidae), a new tardigrade species from Calvert Island (British Columbia, Canada)
2022
Tardigrades reports from British Columbia (Canada) trace back to 1908 and numerous species have been recorded from this region, despite the relatively few published sampling studies. We describe by integrative taxonomy (light microscopy morphology, morphometrics, and DNA sequencing) a new tardigrade species, Sisubiotus hakaiensis sp. nov. from the British Columbia central coast. The new species has been found in moss collected from a vertical rock outcrop near the Hakai Institute Calvert Island Field Station. Sisubiotus hakaiensis sp. nov. differs from all the other known species in the genus by the presence of a labyrinthine layer inside the egg process walls, whereas no consistent differe…
The identity of the tropical African
2016
Abstract Polichne mukonja Griffini, 1908 from Cameroon was hitherto known only from the holotype preserved at the Royal Belgian Institute of Natural Sciences, Brussels. This was probably due to the fact that the genus Polichne Stål, 1874 distributed only in Australia and Papua New Guinea. In view of this distribution, the tropical African species was therefore overlooked in the African literature. The recent discovery of two specimens at the Naturhistorisches Museum, Vienna, now provides us with a better understanding of the identity of this taxon, which is related to the African genus Catoptropteryx Karsch, 1890. Polichne mukonja is here transferred to a new genus Griffinipteryx and both t…
Female Nudity, Interspecies Sexuality and ‘Horseness’ in Laetitia Dosch's Hate (2018)
2022
El objetivo de este artículo es analizar la obra Hate de Laetitia Dosch, estrenada en Lausana en 2018, a la luz de teorías recientes sobre la desnudez femenina, la sexualidad entre especies y la subjetividad animal no humana. Con una mujer completamente desnuda y un semental blanco, el espectáculo gira en torno a la posibilidad de comunicación entre especies y la necesidad de reevaluar el significado de la humanidad y la animalidad a través de la representación teatral. Comienzo recurriendo a los escritos de Derrida sobre el tema de la vergüenza y la desnudez como un medio para explorar la identificación entre especies. Luego me dirijo a las teorías ecofeministas recientes para discutir la …
Gill area explains deviations from body size–metabolic rate relationship in teleost fishes
2022
Whether gill area constrains fish metabolism through oxygen limitation is a debated topic. Here, the authors provide insights into this question by analysing mass-specific metabolic rates across 44 teleost fishes extracted from FishBase. They explore whether species deviations from metabolic rates predicted by body mass can be explained by species gill area. They show that the gill area explains c. 26%–28% of species-level deviations from mass-specific metabolic rates. Their findings suggest that gill area might indeed be one of the factors limiting metabolic rate in fishes.
Taxonomy and ecology of metazoan parasites of otariids from Patagonia, Argentina : adult and infective stages
2013
At present, the metazoan parasite fauna of most species of otariids is generally poorly known, in part because these marine mammals are mostly protected and, therefore, sampling is limited to specimens stranded on the coast or captured as by-catch in fisheries. Similar problems also occur for the larval stages of gastrointestinal helminths of otariids. For most of these parasite species, the specific identity of the intermediate/paratenic of hosts is unknown and, therefore, many stages of their life cycles remain to be described. Similarly, little is known about the routes of transmission of these parasites between intermediate/paratenic hosts to their otariids definitive hosts. The present…
Prenatal thyroid hormones accelerate postnatal growth and telomere shortening in wild great tits
2021
AbstractEarly-life environment is known to affect later-life health and disease, which could be mediated by the early-life programming of telomere length, a key hallmark of ageing. According to thefetal programming of telomere biology hypothesis, variation in prenatal exposure to hormones is likely to influence telomere length. Yet the contribution of key metabolic hormones,i.e. thyroid hormones (THs), has been largely ignored. We recently showed that in contrast to predictions, exposure to elevated prenatal THs increased postnatal telomere length in wild collared flycatchers, but the generality of such effect, its underlying proximate mechanisms and consequences on survival have not been i…
Desarrollo de modelos experimentales de LGMDD2 y rastreo de fármacos
2023
La distrofia muscular de cinturas tipo D2 (Limb-girdle muscular dystrophy type D2, LGMDD2) es una enfermedad genética ultra rara para la cual no existe tratamiento. Las principales características clínicas de la LGMDD2 son la debilidad y degeneración muscular progresiva que afecta a las cinturas pélvica y escapular de forma predominante. En 2013 se identificó la LGMDD2 como una miopatía autosómica dominante causada por una mutación en el gen de la transportina 3 (TNPO3), dando como resultado una proteína mutante con una extensión de 15 aminoácidos adicionales: TNPO3mut. TNPO3 es una β-importina responsable de la importación nuclear de proteínas ricas en serina/arginina (proteínas SR), invol…
On the Choice of the Extracellular Vesicles for Therapeutic Purposes
2019
Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives
2020
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical com…