Search results for "Aortic"
showing 10 items of 619 documents
Aortic stenosis: insights on pathogenesis and clinical implications
2016
Aortic stenosis (AS) is a common valvular heart disease in the Western populations, with an estimated overall prevalence of 3% in adults over 75 years. To understand its patho-biological processes represents a priority. In elderly patients, AS usually involves trileaflet valves and is referred to as degenerative calcific processes. Scientific evidence suggests the involvement of an active "atherosclerosis-like" pathogenesis in the initiation phase of degenerative AS. To the contrary, the progression could be driven by different forces (such as mechanical stress, genetic factors and interaction between inflammation and calcification). The improved understanding presents potentially new thera…
Endovascular Aneurysm Repair
2002
Background — The purpose of the present study was to systematically analyze the histopathologic organization processes in excluded aneurysms after endovascular stenting and to develop a noninvasive monitoring method for these processes using MRI. Methods and Results — In 36 mongrel dogs, autologous aortic aneurysms were created. Endovascular treatment was performed using covered stents. Follow-up was after 1 week, 6 weeks, and 6 months. MRI was performed with T 2 -weighted turbo-spin-echo sequences and T 1 -weighted spin-echo sequences and was repeated after contrast bolus with gadolinium. Histopathologic findings were correlated to signal intensities (SIs) of MRI images. SIs of distinct a…
Role of computational modeling in thoracic aortic pathology: A review
2014
Thoracic aortic diseases are life-threatening conditions causing significant mortality and morbidity despite advances in diagnostic and surgical treatments. Computational methods combined with imaging techniques provide quantitative information of disease progression, which may improve clinical treatments and therapeutic strategies for clinical practice. Since hemodynamic and wall mechanics play important roles in the natural history and progression of aortic diseases, we reviewed the potential application of computational modeling of the thoracic aorta. We placed emphasis on the clinical relevance of these techniques for the assessment of aortic dissection, thoracic aortic aneurysm, and ao…
In Vitro Measurement of Strain Localization Preceding Dissection of the Aortic Wall Subjected to Radial Tension
2020
AbstractBackgroundAortic dissection (AD) is a common pathology and challenging clinical problem. A better understanding of the biomechanical effects preceding its initiation is essential for predicting adverse events on a patient-specific basis. Moreover, the predictability of patient-specific biomechanics-based computational models is hampered by uncertainty about boundary conditions and material properties.ObjectivePredisposition of thoracic aortic aneurysms (TAA) to ADs can be related to the degradation of biomechanically important constituents in the aortic wall of TAAs. The goal of the present study is to develop a new methodology to measure strain fields in aortic tissues subjected to…
Dissecting Abdominal Aortic Aneurysm Is Aggravated by Genetic Inactivation of LIGHT (TNFSF14)
2021
Abdominal aortic aneurysm (AAA), is a complex disorder characterized by vascular vessel wall remodeling. LIGHT (TNFSF14) is a proinflammatory cytokine associated with vascular disease. In the present study, the impact of genetic inactivation of Light was investigated in dissecting AAA induced by angiotensin II (AngII) in the Apolipoprotein E-deficient (Apoe−/−) mice. Studies in aortic human (ah) vascular smooth muscle cells (VSMC) to study potential translation to human pathology were also performed. AngII-treated Apoe−/−Light−/− mice displayed increased abdominal aorta maximum diameter and AAA severity compared with Apoe−/− mice. Notably, reduced smooth muscle α-actin+ area and Acta2 and C…
Dissection and 3D reconstruction of healthy and aneurysmal human ascending thoracic aorta
2010
Ascending thoracic aortic aneurysm (ATAA) is among the most devastating forms of cardiovascular disease, causing a significant mortality despite current medical and surgical treatments [1]. This form of disease is a predisposing factor for spontaneous aortic dissection which in general results in the initiation of an intimal flap and its propagation due to blood flow. Since aortic dissection fails by separation of the elastic layers [2], the delamination strength of ATAA tissues was investigated by designing and performing mechanical tests that simulate the in-vivo tearing condition of the aortic wall. Specifically, the delamination tests were carried out on nonaneurysmal and aneurysmal hum…
ECG-gated multislice computed tomography angiography as a comprehensive non-invasive imaging tool in patient with aortic coarctation
2021
We describe a case of a 52-year-old-woman with aortic coarctation demonstrated by means of 40-slice MSCT angiography. Based on the information extracted from MSCT it was possible to display the anatomical configuration of the disease, the thoraco-abdominal collateral pathways. The best therapeutic approach was established on the basis of MSCT findings. MSCT is a reliable and comprehensive tool for the assessment of adult patients with aortic coarctation. (www.actabiomedica.it).
ASSOCIAZIONE TRA INDICE DI RESISTENZA INTRARENALE E STIFFNESS AORTICA IN SOGGETTI CON MALATTIA RENALE CRONICA
2014
RAZIONALE. L’indice di resistenza intraparenchimale renale (IR), valutato mediante eco-color-Doppler, è stato classicamente utilizzato quale valido strumento di valutazione diagnostica e prognostica delle patologie renali. Studi recenti suggeriscono che i parametri emodinamici intrarenali, e l’IR in particolare, possano essere anche associati ad alterazioni vascolari sistemiche, nonché ad un incremento del rischio cardiovascolare. Tuttavia, dati contrastanti esistono in letteratura circa l'associazione indipendente tra IR e pulse wave velocity aortica (PWVa), indice di stiffness arteriosa, nonché espressione di danno d'organo subclinico. Scopo di questo studio è stato dunque quello di valut…
Transcatheter aortic valve implantation in 2015
2016
Not available
UTILITÀ DI UN BASSO CUT-OFF DI INDICE DI RESISTENZA INTRARENALE NEL PREDIRE ALTERAZIONI VASCOLARI SISTEMICHE PRECOCI IN SOGGETTI CON IPERTENSIONE ART…
2014
Studi recenti mostrano come l’indice di resistenza intraparenchimale renale (IR), classicamente considerato espressione di resistenza vascolare renale, possa avere un importante ruolo quale marker di alterazioni vascolari sistemiche. Il valore soglia di IR il più spesso utilizzato per identificare pazienti con maggiore probabilità di danno d’organo e di mortalità è stato 0.70. Non è stato tuttavia verificato se un cut-off più basso abbia una maggiore capacità di identificare alterazioni vascolari sistemiche subcliniche. Scopo del nostro studio è pertanto quello di determinare, in soggetti con ipertensione arteriosa essenziale (EH), il valore di IR renale che meglio predica l’esistenza di un…