Search results for "Api"
showing 10 items of 8586 documents
Geometrical deviation of end-of-life parts as a consequence of reshaping by single point incremental forming
2021
AbstractPutting in place circular economy strategies is an urgent challenge to face. In this scenario, manufacturing processes play a relevant role as efficient material reuse enabler. Scientists have to make an effort either to find new process or to rethink old process to reprocess end-of-life (EoL) component to recover both material and functions. In this paper, single point incremental forming (SPIF) process is used for reshaping sheet metal EoL components. The entire process chain was replicated including both deep drawing process (to imitate the end-of-life component) as well as SPIF operations (to obtain the reshaped components). The geometrical deviation as a consequence of SPIF ope…
Manufacturing processes as material and energy efficiency strategies enablers: The case of Single Point Incremental Forming to reshape end-of-life me…
2021
Abstract Making materials consumes about 21% of the global energy demand; concerning metals production, it accounts for about 8% of total global energy consumption. Circular economy strategies such as longer life, more intense use, repair, product upgrades, modularity, remanufacturing, component reuse, and open/closed-loop recycling are strategies to put in place urgently to reduce the environmental impact of raw material production. Although recycling of metals is the most used strategy and is being improved in terms of efficiency, it is mandatory moving towards more virtuous circular economy strategies, such as product/component reuse. In this paper a novel reuse strategy for sheet metal …
Re-forming end-of-life components through single point incremental forming
2020
Abstract Applying Circular Economy strategies is mandatory to face material demand while minimizing the environmental impact. Manufacturing processes are to be thought as means to enable material/component reuse strategies. This paper presents the suitability of Single Point Incremental Forming (SPIF) to re-form End-of-life sheet metal components. Deep drawing followed by SPIF process on aluminium alloys were carried out to simulate reforming processes chain. The resulting thinning and strain distributions were experimentally analysed for different configurations. The research proves that the local action and enhanced formability nature of SPIF allow non-homogeneously thinned and reduced fo…
Manufacturing strategies for efficiency in energy and resources use: The role of metal shaping processes
2017
Abstract Manufacturing sector nowadays has to deal with the global need to reduce the environmental impact of human activity. As manufacturing accounts for a significant portion of the global CO 2 emissions, scientific research should be addressed to understand the environmental impact of manufacturing processes and, in the meantime, to take advantage of their full potential in reducing the overall CO 2 emissions. The present review paper aims at describing the role of metal shaping processes in reducing the environmental impact across different stages of metal components life. Actually, an increased consciousness concerning both the environmental performances of manufacturing processes and…
The open metastable structure of a collapsible sand: fabric and bonding
2015
This paper deals with the compositional and textural characteristics determining open metastable structures in the pleistocenic sand outcropping in the Agrigento district (Sicily). The aim of the study was to individuate the bonding types occurring between grains that could generate matric suction phenomena. The composition and microfabric were characterised by means of granulometry, porosimetry, permeability, optical and ESEM-EDS microscopy, thermogravimetry and XR diffractometry, electric conductivity, and ionic chromatography. The data thus acquired show that the skeleton of the sand is constituted mostly by bioclasts and microfossils, calcite and quartz monocrystalline grains. Moreover,…
Estrés y drogadicción: una perspectiva actualizada para 2020
2020
The role of stress in addiction is complex. In this editorial we highlight the main issues of interest in the ongoing research in relation to drug addiction and stress from an up-to-date perspective. Thus, taking into account that several bibliographic reviews have been published recently on the subject, the aim of this editorial has been to gather updated information in order to point out future directions of research that could make a valuable contribution to the knowledge about addictions and the role that stress plays in them. Finally, we stress the need for interdisciplinary research that addresses stress and addictions by incorporating and integrating physical and psychosocial facto…
Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment
2018
Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this approach might still remaininefficient and may cause many side effects, including severe complications and even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared with conventional therapies, allowing the possibility for improved effect in cancer therapy. Chemotherapeutics combined with oncolytic viruses exhibit stronger cytotoxic responses and oncolysis. Here, we have investigated the systemic delivery of the oncolytic adenovirus and paclitaxel encapsulated in extracellular vesicles (EV) formulation that, in vitro, s…
Effect of resource availability on evolution of virulence and competition in an environmentally transmitted pathogen
2018
Understanding ecological and epidemiological factors driving pathogen evolution in contemporary time scales is a major challenge in modern health management. Pathogens that replicate outside the hosts are subject to selection imposed by ambient environmental conditions. Increased nutrient levels could increase pathogen virulence by pre-adapting for efficient use of resources upon contact to a nutrient rich host or by favouring transmission of fast-growing virulent strains. We measured changes in virulence and competition in Flavobacterium columnare, a bacterial pathogen of freshwater fish, under high and low nutrient levels. To test competition between strains in genotype mixtures, we devel…
The torso integration hypothesis revisited in Homo sapiens: Contributions to the understanding of hominin body shape evolution.
2018
Objectives: Lower thoracic widths and curvatures track upper pelvic widths and iliac blades curvatures in hominins and other primates (torso integration hypothesis). However, recent studies suggest that sexual dimorphism could challenge this assumption in Homo sapiens. We test the torso integration hypothesis in two modern human populations, both considering and excluding the effect of sexual dimorphism. We further assess covariation patterns between different thoracic and pelvic levels, and we explore the allometric effects on torso shape variation. Material and Methods: A sex-balanced sample of 50 anatomically connected torsos (25 Mediterraneans, 25 Sub-Saharan Africans) was segmented fro…
Detection of RET rearrangements in papillary thyroid carcinoma using RT-PCR and FISH techniques - A molecular and clinical analysis.
2019
Abstract Introduction Oncogenic BRAF and RAS mutations as well as multiple known (and yet unknown) RET fusion oncogenes comprise the majority of causative molecular alterations in papillary thyroid carcinoma (PTC). Apparently “mutation-negative” PTCs encompass a heterogenous group impeding analysis of prognostic significance of underlying genetics. Material and methods BRAF wild type PTC tissue of 56 patients was analyzed using two established methods: hybrid-specific RT-PCR for the predominant rearrangement RET/PTC1 and fluorescent in situ hybridization (FISH). Clinical features of the cases with and without RET rearrangement were compared (patient age, gender, tumor size, focality, lymph …