Search results for "Application"
showing 10 items of 5559 documents
There’s a Double Tongue in Cheek: On the Un(Translatability) of Shakespeare’s Bawdy Puns into Romanian
2017
AbstractThe translatability of William Shakespeare’s titillating puns has been a topic of recurrent debate in the field of translation studies, with some scholars arguing that they are untranslatable and others maintaining that such an endeavour implies a divorce from formal equivalence. Romanian translators have not troubled themselves with settling this dispute, focusing instead on recreating them as bawdily and punningly as possible in their first language. At least, this is the conclusion to which George Volceanov has come after analysing a sample of Shakespearean ribald puns and their Romanian equivalents. By drawing parallels between such instances of the Bard’s rhetoric and three of …
Antiproliferative Activity Predictor: A New Reliable In Silico Tool for Drug Response Prediction against NCI60 Panel.
2022
In vitro antiproliferative assays still represent one of the most important tools in the anticancer drug discovery field, especially to gain insights into the mechanisms of action of anticancer small molecules. The NCI-DTP (National Cancer Institute Developmental Therapeutics Program) undoubtedly represents the most famous project aimed at rapidly testing thousands of compounds against multiple tumor cell lines (NCI60). The large amount of biological data stored in the National Cancer Institute (NCI) database and many other databases has led researchers in the fields of computational biology and medicinal chemistry to develop tools to predict the anticancer properties of new agents in advan…
An improved smoothed particle electromagnetics method in 3D time domain simulations
2011
In this paper, an enhanced variant of the meshless smoothed particle electromagnetics (SPEM) method is performed in order to solve PDEs in time domain describing 3D transient electromagnetic phenomena. The method appears to be very efficient in approximating spatial derivatives in the numerical treatment of Maxwell's curl equations. In many cases, very often, accuracy degradation, due to a lack of particle consistency, severely limits the usefulness of this approach. A numerical corrective strategy, which allows to restore the SPEM consistency, without any modification of the smoothing kernel function and its derivatives, is presented. The method allows to restore the same order of consiste…
On real-time algorithms for the location search of discontinuous conductivities with one measurement
2008
We discuss, and compare, two simple methods that provide coordinates of a point in the vicinity of one inclusion within some object with homogeneous electrical properties. In the context of nondestructive testing such an inclusion may correspond to a material defect, whereas in medicine this may correspond to a lesion in the brain, to name only two possible applications. Both methods use only one pair of voltage/current measurements on the entire boundary of the object to determine a single pair of coordinates that is considered to be close to the center of the inclusion. The first method has been proposed previously by Kwon, Seo and Yoon; the second method, called here the effective dipole…
Social Network Banking : A Case Study of 100 Leading Global Banks
2018
Social media is widely recognized as a challenging new communication technology in both economic and social contexts. The present article explores how banks have exploited this technology in the range of consumer retail banking services offered by 100 leading global banks on the three major social networking sites (SNS): Facebook, Twitter, and YouTube. Viewing social network (SN) banking as a separate delivery channel and offering a working definition of SN banking, the article shows that banks have been more cautious than other businesses in using SNS. The available services are classified on nine main dimensions: marketing, financial education and advice, information support, customer sup…
Consumers' perceptions of mobile banking continuous usage in Finland and South Africa
2015
This study examines continuous usage behaviour related to mobile banking (m-banking) among consumers living in Finland (FI) and South Africa (ZA). The study investigates three post-adoption behavioural consequences - namely, trust, satisfaction and word of mouth. Using purposeful sampling techniques, we found that trust plays a significant role in promoting continuous usage of m-banking. In general, the respondents reported high levels of trust in m-banking technology and were satisfied with the m-banking application and services. In addition, convenience, user friendliness and speed emerged as the main sub-topics related to satisfaction. In most cases, the convenience of using m-banking do…
Extending customer relationship management. From empowering firms to empowering customers
2013
Purpose – The focus of customer relationship management (CRM) literature has been predominantly on the firm perspective and on IT, not on customer or service orientation and value co-creation. This paper seeks to explore and analyse contemporary CRM frameworks and suggests future research directions. To achieve this, a thorough literature review on CRM is conducted focusing on recent advances within CRM. This provides a good basis for critically analysing the current status of both CRM theory and practice. Design/methodology/approach – The paper reviews CRM literature published 2003-2011. Based on the literature review, it introduces a conceptual framework of the changing role of customer d…
The Modern Strategies in the Cyber Warfare
2018
As there is no generally accepted definition for cyber warfare, it is a term that is quite liberally used in describing events and actions in the digital cyber world. The concept of cyber warfare became extremely popular from 2008 to 2010, partly superseding the previously used concept of information warfare which was launched in the 1990s. For some, cyber warfare is war that is conducted in the virtual domain. For others, it is a counterpart to conventional “kinetic” warfare. According to the OECD’s 2001 report, cyberwar military doctrines resemble those of so-called conventional war: retaliation and deterrence. Researchers agree with the notion that the definition of cyberwar should addre…
Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors.
2011
Reliable and effective virtual high-throughput screening (vHTS) methods are desperately needed to minimize the expenses involved in drug discovery projects. Here, we present an improvement to the negative image-based (NIB) screening: the shape, the electrostatics, and the solvation state of the target protein’s ligand-binding site are included into the vHTS. Additionally, the initial vHTS results are postprocessed with molecular mechanics/generalized Born surface area (MMGBSA) calculations to estimate the favorability of ligand-protein interactions. The results show that docking produces very good early enrichment for phosphodiesterase-5 (PDE-5); however, in general, the NIB and the ligand-…
Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme.
2019
Phosphorylation by kinases enzymes is a widespread regulatory mechanism able of rapidly altering the function of target proteins. Among these are cytochrome P450s (CYP450), a superfamily of enzymes performing the oxidation of endogenous and exogenous substrates thanks to the electron supply of a redox partner. In spite of its pivotal role, the molecular mechanism by which phosphorylation modulates CYP450s metabolism remains elusive. Here by performing microsecond-long all-atom molecular dynamics simulations, we disclose how phosphorylation regulates estrogen biosynthesis, catalyzed by the Human Aromatase (HA) enzyme. Namely, we unprecedentedly propose that HA phosphorylation at Y361 markedl…