Search results for "Application"
showing 10 items of 5559 documents
Epigenomic k-mer dictionaries: shedding light on how sequence composition influences in vivo nucleosome positioning
2014
Abstract Motivation: Information-theoretic and compositional analysis of biological sequences, in terms of k-mer dictionaries, has a well established role in genomic and proteomic studies. Much less so in epigenomics, although the role of k-mers in chromatin organization and nucleosome positioning is particularly relevant. Fundamental questions concerning the informational content and compositional structure of nucleosome favouring and disfavoring sequences with respect to their basic building blocks still remain open. Results: We present the first analysis on the role of k-mers in the composition of nucleosome enriched and depleted genomic regions (NER and NDR for short) that is: (i) exhau…
The Binomial “Inflammation-Epigenetics” in Breast Cancer Progression and Bone Metastasis: IL-1β Actions Are Influenced by TET Inhibitor in MCF-7 Cell…
2022
The existence of a tight relationship between inflammation and epigenetics that in primary breast tumor cells can lead to tumor progression and the formation of bone metastases was investigated. It was highlighted how the induction of tumor progression and bone metastasis by Interleukin-1 beta, in a non-metastatic breast cancer cell line, MCF-7, was dependent on the de-methylating actions of ten-eleven translocation proteins (TETs). In fact, the inhibition of their activity by the Bobcat339 molecule, an inhibitor of TET enzymes, determined on the one hand, the modulation of the epithelial-mesenchymal transition process, and on the other hand, the reduction in the expression of markers of bo…
Potential Anti-Metastatic Role of the Novel miR-CT3 in Tumor Angiogenesis and Osteosarcoma Invasion
2022
Osteosarcoma (OS) is the most common primary bone tumor mainly occurring in young adults and derived from primitive bone-forming mesenchyme. OS develops in an intricate tumor microenvironment (TME) where cellular function regulated by microRNAs (miRNAs) may affect communication between OS cells and the surrounding TME. Therefore, miRNAs are considered potential therapeutic targets in cancer and one of the goals of research is to accurately define a specific signature of a miRNAs, which could reflect the phenotype of a particular tumor, such as OS. Through NGS approach, we previously found a specific molecular profile of miRNAs in OS and discovered 8 novel miRNAs. Among these, we deepen our …
Improved GNSS positioning exploiting a vehicular P2P infrastructure
2010
This paper considers the possibility to exploit external altitude measurements to improve the performance of a Kalman based GNSS receiver. The altitude measurements are provided by means of a peer to peer network, that is supposed to be based on the evolution of the 802.11 standard for the vehicular environment, namely the WAVE (802.11p). The performance of such a system are investigated for different characteristics of the aiding measurement and for a different number and disposals of the aiding peers. The aiding measurement is obtained starting from the altitude measurements that the other peers in the network send to the aided user. The experiments highlight the need for a parameter that…
Two Half-Truths Make a Whole? On Bias in Self-Reports and Tracking Data
2019
The pervasive use of mobile information technologies brings new patterns of media usage, but also challenges to the measurement of media exposure. Researchers wishing to, for example, understand the nature of selective exposure on algorithmically driven platforms need to precisely attribute individuals’ exposure to specific content. Prior research has used tracking data to show that survey-based self-reports of media exposure are critically unreliable. So far, however, little effort has been invested into assessing the specific biases of tracking methods themselves. Using data from a multimethod study, we show that tracking data from mobile devices is linked to systematic distortions in sel…
Graphene coating obtained in a cold-wall CVD process on the Co-Cr Alloy (L-605) for medical applications
2021
Graphene coating on the cobalt-chromium alloy was optimized and successfully carried out by a cold-wall chemical vapor deposition (CW-CVD) method. A uniform layer of graphene for a large area of the Co-Cr alloy (discs of 10 mm diameter) was confirmed by Raman mapping coated area and analyzing specific G and 2D bands
Anti-Eryptotic Activity of Food-Derived Phytochemicals and Natural Compounds
2022
Human red blood cells (RBCs), senescent or damaged due to particular stress, can be removed by programmed suicidal death, a process called eryptosis. There are various molecular mechanisms underlying eryptosis. The most frequent is the increase in the cytoplasmic concentration of Ca2+ ions, later exposure of erythrocytes to oxidative stress, hyperosmotic shock, ceramide formation, stimulation of caspases, and energy depletion. Phosphatidylserine (PS) exposed by eryptotic RBCs due to interaction with endothelial CXC-Motiv-Chemokin-16/Scavenger-receptor, causes the RBCs to adhere to vascular wall with consequent damage to the microcirculation. Eryptosis can be triggered by various xenobiotics…
Volatility transmission patterns and terrorist attacks
2009
The objective of this study is to analyze volatility transmission between the US and Eurozone stock markets considering the effects of the September 11, March 11 and July 7 financial crises. In order to do this, we use a multivariate GARCH model and take into account the asymmetric volatility phenomenon, the non-synchronous trading problem and the crises themselves. Moreover, a graphical analysis of the Asymmetric Volatility Impulse-Response Functions (AVIRF) is introduced, which takes into consideration the crisis effect. Results suggest that there is bidirectional and asymmetric volatility transmission and show the different impact that terrorist attacks had on both markets. El objetivo d…
Ethernet FSO Communications Link Performance Study Under a Controlled Fog Environment
2012
In this letter the performance of a free space optical (FSO) communication link in the presence of fog is experimentally investigated in an indoor environment. A dedicated indoor atmospheric chamber, replicating the outdoor environment, is being used to evaluate the FSO link performance under the fog condition. Theoretical analysis supported by the experimental evaluation has been carried out for the intensity modulation/direct detection on-off keying non-return-to-zero (OOK-NRZ), OOK return-to-zero (OOK-RZ) and four pulse position modulation (4-PPM) modulation formats at the Ethernet baseline data-rate. The results shown indicate that the 4-PPM signalling scheme is the most robust to the f…
A CORBA based architecture for distributed embedded systems using the RTLinux-GPL platform
2004
This paper describes an architecture for distributed computing on the RTLinux-GPL(GPL version of RTLinux, hereafter RTLinux) platform. The proposed architecture implements the CORBA (common object request broker architecture) model of computation, more specifically the minimum CORBA specification for embedded systems, and also provide the extensions for real-time computing. Since RTLinux lacks networking capabilities, the architecture implements all the required functionality in a layered fashion: network drivers, TCP/IP stack and an ORB (object request broker). Most of this work consists on a set of partings of some widely known open source Linux projects to RTLinux: Linux Ethernet device …