Search results for "Application"
showing 10 items of 5559 documents
Molecular and Cellular Insights into the Development of Uterine Fibroids
2021
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-dependent smooth-muscle formations occur with an estimated prevalence of ~70% among women of reproductive age and cause symptoms including pain, abnormal uterine bleeding, infertility, and recurrent abortion. Despite the prevalence and public health impact of uterine leiomyomas, available treatments remain limited. Among the potential causes of leiomyomas, early hormonal exposure during periods of development may result in developmental reprogramming via epigenetic changes that persist in adulthood, leading to disease onset or progression. Recent developments in unbiased high-throughput sequencing technolog…
The Role of Ancestral Duplicated Genes in Adaptation to Growth on Lactate, a Non-Fermentable Carbon Source for the Yeast Saccharomyces cerevisiae
2021
This article belongs to the Section Molecular Informatics.
Selective phenotyping, entropy reduction, and the mastermind game.
2011
Abstract Background With the advance of genome sequencing technologies, phenotyping, rather than genotyping, is becoming the most expensive task when mapping genetic traits. The need for efficient selective phenotyping strategies, i.e. methods to select a subset of genotyped individuals for phenotyping, therefore increases. Current methods have focused either on improving the detection of causative genetic variants or their precise genomic location separately. Results Here we recognize selective phenotyping as a Bayesian model discrimination problem and introduce SPARE (Selective Phenotyping Approach by Reduction of Entropy). Unlike previous methods, SPARE can integrate the information of p…
Population genetic analysis of bi-allelic structural variants from low-coverage sequence data with an expectation-maximization algorithm
2014
Background Population genetics and association studies usually rely on a set of known variable sites that are then genotyped in subsequent samples, because it is easier to genotype than to discover the variation. This is also true for structural variation detected from sequence data. However, the genotypes at known variable sites can only be inferred with uncertainty from low coverage data. Thus, statistical approaches that infer genotype likelihoods, test hypotheses, and estimate population parameters without requiring accurate genotypes are becoming popular. Unfortunately, the current implementations of these methods are intended to analyse only single nucleotide and short indel variation…
Motzkin subposets and Motzkin geodesics in Tamari lattices
2014
The Tamari lattice of order n can be defined by the set D n of Dyck words endowed with the partial order relation induced by the well-known rotation transformation. In this paper, we study this rotation on the restricted set of Motzkin words. An upper semimodular join semilattice is obtained and a shortest path metric can be defined. We compute the corresponding distance between two Motzkin words in this structure. This distance can also be interpreted as the length of a geodesic between these Motzkin words in a Tamari lattice. So, a new upper bound is obtained for the classical rotation distance between two Motzkin words in a Tamari lattice. For some specific pairs of Motzkin words, this b…
An integrated geodetic and InSAR technique for the monitoring and detection of active faulting in southwestern Sicily
2020
We present the results of the analysis of GNSS (Global Navigation Satellite System) and InSAR (Interferometric synthetic-aperture radar) data collected in the frame of a project financed by the “Struttura Terremoti” of INGV (Istituto Nazionale di Geofisica e Vulcanologia). Combined investigations pointed out for potential seismogenic sources for destructive earthquakes recorded in southwestern Sicily, including the 1968 Belice earthquake sequence and that supposed to have destroyed the Greek city of Selinunte which, according to geoarcheological data experienced two earthquakes in historical times. Our approach is aimed to evaluate the current deformation rate in SW Sicily and to improve th…
Investigating effects in GNSS station coordinate time series
2014
The vertical and horizontal displacements of the Earth can be measured to a high degree of precision using GNSS. Time series of Latvian GNSS station positions of both the EUPOS®-Riga and LatPos networks have been developed at the Institute of Geodesy and Geoinformation of the University of Latvia (LU GGI). In this study the main focus is made on the noise analysis of the obtained time series and site displacement identification. The results of time series have been analysed and distinctive behaviour of EUPOS®-Riga and LatPos station coordinate changes have been identified. The possible dependences of GNSS station coordinate distribution on EPN station problems, seismic activity of some area…
Bio-Eco-Analysis for Risk Factors using GIS Software
2013
Agriculture is a business sector ideally suited for the application of Geographic Information Systems (GIS) because it is natural resource based, requires the movement, distribution, and/or utilization of large quantities of products, goods, and services, and is increasingly required to record details of its business operations from the field to the marketplace. Nearly all agricultural data has some form of spatial component, and a GIS allows you to visualize information that might otherwise be difficult to interpret. Environment has a major impact on agriculture. In this paper we presented how GIS software can be used to analyze risk factors that influence agricultural production naturally…
Càlcul de coordenades geogràfiques a partir de les estrelles: una proposta didàctica entre les matemàtiques i l'astronomia
2016
[EN] This paper presents a didactical proposal for 11th grade students. The purpose of the activities is to show the relationship between astronomy and mathematics, specifically with the calculation of both geographic coordinates: latitude and longitude. The methodology used encourages independent work of students by using interactive digital applications and manipulative materials. These ressources allow students to work more easily with threedimensional geometry concepts that, otherwise, are abstract for them. The proposal is based on a classic problem: find the exact geographic position of any point on the Earth.
Development of the One Centimeter Accuracy Geoid Model of Latvia for GNSS Measurements
2015
There is an urgent necessity for a highly accurate and reliable geoid model to enable prompt determination of normal height with the use of GNSS coordinate determination due to the high precision requirements in geodesy, building and high precision road construction development. Additionally, the Latvian height system is in the process of transition from BAS- 77 (Baltic Height System) to EVRS2007 system. The accuracy of the geoid model must approach the precision of about ~1 cm looking forward to the Baltic Rail and other big projects. The use of all the available and verified data sources is planned, including the use of enlarged set of GNSS/levelling data, gravimetric measurement data and…