Search results for "Application"
showing 10 items of 5559 documents
Transcriptomic and Bioinformatic Analyses Identifying a Central Mif-Cop9-Nf-kB Signaling Network in Innate Immunity Response of Ciona robusta
2023
The Ascidian C. robusta is a powerful model for studying innate immunity. LPS induction activates inflammatory-like reactions in the pharynx and the expression of several innate immune genes in granulocyte hemocytes such as cytokines, for instance, macrophage migration inhibitory factors (CrMifs). This leads to intracellular signaling involving the Nf-kB signaling cascade that triggers downstream pro-inflammatory gene expression. In mammals, the COP9 (Constitutive photomorphogenesis 9) signalosome (CSN) complex also results in the activation of the NF-kB pathway. It is a highly conserved complex in vertebrates, mainly engaged in proteasome degradation which is essential for maintaining proc…
Electromagnetic response of LaO_0.94F_0.06FeAs: AC susceptibility and microwave surface resistance
2009
We discuss on the electromagnetic response of a polycrystalline sample of LaO_0.94F_0.06FeAs exposed to DC magnetic fields up to 10 kOe. The low- and high-frequency responses have been investigated by measuring the AC susceptibility at 100 kHz and the microwave surface resistance at 9.6 GHz. At low as well as high DC magnetic fields, the susceptibility strongly depends on the amplitude of the AC driving field, highlighting enhanced nonlinear effects. The field dependence of the AC susceptibility exhibits a magnetic hysteresis that can be justified considering the intragrain-field-penetration effects on the intergrain critical current density. The microwave surface resistance exhibits a cloc…
Young People's Translocal New Media Uses: A Multiperspective Analysis Of Language Choice And Heteroglossia
2009
The aim of this paper is to shed light on the particularities of the linguistic, social and cultural action of young Finns in translocal new media spaces, and the ways in which they themselves make sense of and account for their actions. We present findings from 4 case studies, each of which illustrates aspects of translocality in young Finns' new media uses. Theoretically and methodologically the case studies draw on sociolinguistics, discourse studies, and ethnography, making use of the concepts of language choice and linguistic and stylistic heteroglossia. Through the 4 cases in focus, the paper shows how young people's linguistically and textually sophisticated new media uses are geared…
DIAMIN: a software library for the distributed analysis of large-scale molecular interaction networks
2022
AbstractBackgroundHuge amounts of molecular interaction data are continuously produced and stored in public databases. Although many bioinformatics tools have been proposed in the literature for their analysis, based on their modeling through different types of biological networks, several problems still remain unsolved when the problem turns on a large scale.ResultsWe propose , that is, a high-level software library to facilitate the development of applications for the efficient analysis of large-scale molecular interaction networks. relies on distributed computing, and it is implemented in Java upon the framework Apache Spark. It delivers a set of functionalities implementing different ta…
Probing Lorentz invariance and other fundamental symmetries in3He/129Xe clock-comparison experiments
2011
We discuss the design and performance of a very sensitive low-field magnetometer based on the detection of free spin precession of gaseous, nuclear polarized 3He or 129Xe samples with a SQUID as magnetic flux detector. Characteristic spin precession times T*2 of up to 60 h were measured in low magnetic fields (about 1μT) and in the regime of motional narrowing. With the detection of the free precession of co-located 3He/129Xe nuclear spins (clock comparison), the device can be used as ultra-sensitive probe for non-magnetic spin interactions, since the magnetic dipole interaction (Zeeman-term) drops out in the weighted frequency difference, i.e., Δω = ωHe− γHe/γXe·ωXe. We report on searches …
Method to Define User Interfaces in the Requirements Analysis Phase
2018
Many requirements for quality in use are elicited in the late development phase. However, if requirements are elicited in the late development phase, the development may return to the previous phase or some requirements cannot be realized due to costs and schedules. To reduce these cases, we propose a method to elicit the requirements in the requirements analysis phase. First, software developers analyze the user characteristics (UCs) of the target users and specify important quality characteristics (QCs) for quality in use and UI design items based on the relationships among UC, QC, and UI design items. Because UI design items are considerations to develop UIs, the specified UI design item…
Leader election and local identifiers for three‐dimensional programmable matter
2020
International audience; In this paper, we present two deterministic leader election algorithms for programmable matter on the face-centered cubic grid. The face-centered cubic grid is a 3-dimensional 12-regular infinite grid that represents an optimal way to pack spheres (i.e., spherical particles or modules in the context of the programmable matter) in the 3-dimensional space. While the first leader election algorithm requires a strong hypothesis about the initial configuration of the particles and no hypothesis on the system configurations that the particles are forming, the second one requires fewer hypothesis about the initial configuration of the particles but does not work for all pos…
Effects of Onshore and Offshore Environmental Parameters on the Leading Edge Erosion of Wind Turbine Blades: A Comparative Study
2021
Abstract The presence of rain-induced leading edge erosion of wind turbine blades (WTBs) necessitates the development of erosion models. One of the essential parameters for erosion modeling is the relative impact velocity between rain droplets and the rotating blade. Based on this parameter, the erosion damage rate of a WTB is calculated to estimate the expected leading edge lifetime. The environmental conditions that govern this parameter have site-specific variations, and thus, rain and wind loading on a turbine differ for onshore and offshore locations. In addition, there are wave loads present in the offshore environment. The present paper tries to provide guidelines for erosion modelin…
Nonlinear scaled models in 3D calculation of transformer magnetic circuits
2006
PurposeTo make easier and faster the designing of transformers using scale models.Design/methodology/approachThe scale modeling in designing of transformers is included. Both computer and physical models of high leakage reactance (HLR) and 3‐phase (TP3C) transformers have been considered. The 3D field computations have been executed for the scaled models, and the results were recalculated to the full‐scaled ones.FindingsIt is possible to calculate the scale coefficients for nonlinear models of transformers using finite element method (FEM) software. Obtained coefficients are useful in the designing process. Measurements confirm correctness of the scaling laws.Research limitations/implicatio…