Search results for "Architecture"

showing 10 items of 3706 documents

InCREDulity in Artificial Societies

2021

This paper describes an artificial society in which the simulated agents behave and interact based on a computational architecture informed by insights from one of the leading social psychological theories in the scientific study of secularization and religion: “credibility-enhancing displays” (or CREDs) theory. After introducing the key elements of the theory and outlining the computational architecture of our CRED model, we present some of our initial simulation results. These efforts are intended to advance the quest within social simulation for more authentic artificial societies and more plausible human-like agents with complex interactive and interpretative capacities.

Agent-based modelCognitive scienceComputational architectureComputer scienceArtificial societySecularizationKey (cryptography)Scientific studySocial simulation
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Modeling Radicalization and Violent Extremism

2020

Given public anxiety about radicalization and violent extremism, it is not surprising that these topics have grabbed the attention of so many scholars in recent years. However, some have expressed concern over the fact that only a few studies in this relatively new field contain empirical data or systematic data analysis or develop causal models of the mechanisms generating these phenomena. We believe that computational modeling and simulation techniques can make a significant contribution to this scientific literature and eventually provide new tools for improving policy analysis. Here we briefly describe (1) an integrative theory of violent extremism proposed by Kruglanski and colleagues …

Agent-based modelComputational architectureRadicalizationField (Bourdieu)Scientific literatureSociologyPolicy analysisViolent extremismEpistemologyCausal model
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Living autobiographically: Concepts of aging and artistic expression in painting and modern dance.

2016

This article discusses the ways in which artists have incorporated or failed to incorporate the aging process of their bodies into their art. Using Russian ballet dancer Mikhail Baryshnikov and the French painter Claude Monet as cases in point, we explore situations in which physical changes brought about by aging compromises artists' ability to engage with their artistic medium. Connecting Monet's oeuvre and Baryshnikov's dance performances to life writing accounts, we draw on John Paul Eakin's concept of "living autobiographically": In this vein, life writing research does not only have to take into account concepts of identity as they emerge from life writing narratives, but it also need…

AgingDanceAnthropologyMedicine in the ArtsIdentity (social science)03 medical and health sciences030502 gerontologyHumansNarrativeSociologyDancingPaintingHealth Policy06 humanities and the artsGeneral Medicine060202 literary studiesModern danceLife writingIssues ethics and legal aspectsAutobiographies as TopicExpression (architecture)Aesthetics0602 languages and literaturePaintingsBallet dancer0305 other medical scienceArtJournal of aging studies
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Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021

Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…

AgingMultifactorial InheritanceBLOODEpigenetic clock05 Environmental SciencesbiomarkkeritGenome-wide association studyQH426-470Epigenesis Genetic/dk/atira/pure/core/keywords/icep0302 clinical medicineBiomarkers of agingGWASBiology (General)AdiposityGenetics11832 Microbiology and virology0303 health sciences318 Medical biotechnologyDNA methylation1184 Genetics developmental biology physiologygenomiikkaDna Methylation ; Epigenetic Clock ; Gwasddc:DNA-metylaatioINSIGHTSC-Reactive ProteinepigenetiikkaDNA methylationMENDELIAN RANDOMIZATION/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingEducational StatusICEPGenetic MarkersPROVIDESSUSCEPTIBILITY LOCIBioinformaticsQH301-705.5GenomicsBiology03 medical and health sciencesNHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumAGESDG 3 - Good Health and Well-beingPlasminogen Activator Inhibitor 1REGRESSIONGeneticsHumansEpigeneticsGeneMETAANALYSIS030304 developmental biologyGenome HumanResearchGenetics of DNA Methylation Consortium06 Biological SciencesLipid MetabolismHuman geneticsGenetic architectureImmunity InnateikääntyminenGenetic LociCpG Islands08 Information and Computing Sciences3111 BiomedicineENRICHMENTepigenetic clock030217 neurology & neurosurgeryBiomarkersGenome-Wide Association StudyGranulocytes
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36 Altered Prefrontal Cortex Responses in Older Adults with Subjective Memory Complaints and Dementia During Dual-Task Gait: An Fnirs Study

2019

Abstract In this study, we investigated the effects of walking during single-task and dual-task gait (STG and DTG) conditions, on left prefrontal cortex (LPFC) activation in older adults with subjective memory complaints (SMC) and Dementia. A total of 72 older adults (aged 65-94 yrs; 33 Healthy; 28 SMC; 11 Dementia) were recruited from the community and assisted living facilities. A portable 7m zeno walkway gait analysis mat was used to measure stride, velocity, length and duration during 4 passes of STG and DTG each. A portable single-channel functional near-infrared spectroscopy (fNIRS) device (Portalite, Artinis Medical Systems) was placed over the LPFC to measure changes in oxyhaemoglob…

Agingmedicine.medical_specialtybusiness.industryGeneral MedicineSubjective memoryDUAL (cognitive architecture)medicine.diseaseTask (project management)Physical medicine and rehabilitationGait (human)medicineDementiaGeriatrics and GerontologybusinessPrefrontal cortexAge and Ageing
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Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis

2014

Objective. Redox imbalance contributes to bone fragility. We have evaluated the in vivo role of nuclear factor erythroid derived 2-related factor-2 (Nrf2), an important regulator of cellular responses to oxidative stress, in bone metabolism using a model of postmenopausal osteoporosis. Methods. Ovariectomy was performed in both wild-type and mice deficient in Nrf2 (Nrf2-/-). Bone microarchitecture was analyzed by CT. Serum markers of bone metabolism were also measured. Reactive oxygen species production was determined using dihydrorhodamine 123. Results. Sham-operated or ovariectomized Nrf2 -/- mice exhibit a loss in trabecular bone mineral density in femur, accompanied by a reduction in co…

Agingmedicine.medical_specialtycytoarchitectureArticle SubjectNF-E2-Related Factor 2MedicinaOsteoporosisOsteoclastsBone Marrow Cellsprotein deficiencymedicine.disease_causeenvironment and public healthBiochemistryBone resorptionBone remodelingMiceIn vivoInternal medicinemedicineAnimalsFemurcontrolled studyFemurlcsh:QH573-671Cells CulturedMice Knockoutchemistry.chemical_classificationReactive oxygen specieslcsh:CytologyChemistrybone densityCell DifferentiationCell BiologyGeneral Medicinerespiratory systemmedicine.diseaseosteoporosisMice Inbred C57BLDisease Models AnimalOxidative StressEndocrinologyOvariectomized ratReactive Oxygen SpeciesTomography X-Ray ComputedBiomarkersOxidative stressResearch Article
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An imperial town in a time of transition. Life, environment, and decline of early Byzantine Caričin Grad

2016

The site of Caricin Grad in south-eastern Serbia – currently listed on UNESCO’s tentative list – has been the subject of archaeological investigations for more than 100 years. For the last decades it has been the focus of a joint project of the Archaeological Institute in Belgrade and the Ecole Francaise de Rome. A reconstruction of the economic, environmental and social history of the city is the main objective of a cooperative project started in 2014 with the Romisch-Germanisches Zentralmuseum Mainz. The remains of the early Byzantine complex of Caricin Grad show the features of a city built in the classical, Hellenistic-Roman tradition, combined with ecclesiastical Christian architecture…

Agrarian societyGeographybiologyUrban archaeologyAntiqueGeoarchaeologyEconomic historyEmperorHuman ecologyHousehold archaeologybiology.organism_classificationArchaeologyByzantine architectureMulti-, inter- and transdisciplinary research in Landscape Archaeology
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L'edilizia residenziale popolare della prima metà del XX secolo ad Agrigento storia e conservazione

2014

L'articolo costituisce un contributo alla conoscenza del patrimonio dell'edilizia abitativa popolare, nella prima metà del Novecento, della città di Agrigento

Agrigento (Italy) conservation contemporary architecture restauration reusoAgrigento conservazione architettura contemporanea restauro riusoSettore ICAR/19 - Restauro
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Per una lettura socio-economica dei contesti abitativi: L’insula I del Quartiere ellenistico-romano di Agrigento. La domus I A – I B

2021

In linea con le ultime ricerche organizzate dal Parco Archeologico Regionale Valle dei Templi di Agrigento, il cui scopo è la conoscenza dell'antica città di Akragas/Agrigentum come sistema integrato e unitario, si è dedicata nuova attenzione alle forme dell'abitare, in particolare nell'area del cosiddetto "Quartiere ellenistico-romano". Quest'area fu scavata negli anni '50 e '60 del secolo scorso, ma è con la pubblicazione di E. De Miro, avvenuta solo nel 2009, che è stato possibile conoscere i risultati delle indagini. In questo contributo ci si vuole concentrare sull'isolato I del Quartiere, contraddistinto da due grandi abitazioni (I A/B e I E/F) che dominano l'area pubblica dell'agorà.…

Agrigento architettura domestica atrio peristilio PompeiAgrigento Domestic architecture atrium peristylium PompeijSettore L-ANT/07 - Archeologia Classica
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La Casa II A o Casa del mosaico a rombi

2019

Una breve descrizione della Casa II A del quartiere ellenistico-romano di Agrigento A short description of the House II A of the Hellenistic-Roman Quartier in Agrigento

Agrigento domestic architecture of the hellenistic-roman period Roman SicilySettore L-ANT/07 - Archeologia ClassicaAgrigento architettura domestica ellenistico-romana Sicilia romana
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