Search results for "Arid"
showing 10 items of 1382 documents
[Post-translational regulation of N-glycosylated proteins expression in human intestinal cells in culture].
1991
International audience; HT-29 cells derived from a human colonic adenocarcinoma, can express a typical intestinal differentiation. Undifferentiated HT-29 cells accumulate N-linked glycoproteins substituted with unprocessed carbohydrate chains before to degrade them. Conversely, carbohydrate chains of N-linked glycoproteins are classically processed in differentiated HT-29 cells. The instability of N-linked glycoproteins in undifferentiated HT-29 cells is due to their rapid delivery from the endoplasmic reticulum to a compartment with lysosomal characteristics. This catabolitic pathway involves a bypass of the Golgi apparatus.
L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer
2012
Recent work identified L-asparaginase (L-ASP) as a putative therapeutic target for ovarian cancer. We suggest that L-ASP, a dysregulator of glycosylation, would interrupt the local microenvironment, affecting the ovarian cancer cell-endothelial cell interaction and thus angiogenesis without cytotoxic effects. Ovarian cancer cell lines and human microvascular endothelial cells (HMVEC) were exposed to L-ASP at physiologically attainable concentrations and subjected to analyses of endothelial tube formation, invasion, adhesion and the assessment of sialylated proteins involved in matrix-associated and heterotypic cell adhesion. Marked reduction in HMVEC tube formation in vitro, HMVEC and ovari…
Polysaccharide nanocrystals as fillers for PLA based nanocomposites
2016
The development of green nanocomposites based on biopolymers and bio-based nanofillers has attracted over the recent years the attention of academic and industrial research. Indeed, these nanocomposites could replace some oil-derived polymers and thus helping to overcome environmental problems. In this regard, PLA as matrix and polysaccharide nanocrystals as fillers are the most promising components to obtain high-performance green bio-nanocomposites suitable for different applications, particularly for packaging and biomedical applications. Indeed, at present, due to its processability, mechanical and biological properties, as well as its commercial availability, poly(lactic acid) (PLA) po…
The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation model
2006
Melanocortins possess strong anti-inflammatory effects acting in the central nervous system via inhibition of the production of nitric oxide (NO) during brain inflammation. To shed more light into the role of melanocortin (MC) receptor subtypes involved we synthesized and evaluated some novel peptides, modified in the melanocyte-stimulating hormone (MSH) core structure, natural MCs and known MC receptor selective peptides - MS05, MS06. Since the study included both selective, high affinity binders and the novel peptides, it was possible to do the correlation analysis of binding activities and the NO induction-related anti-inflammatory effect of the peptides. beta-MSH, gamma1-MSH, gamma2-MSH…
Effects of overabundant nitrate and warmer temperatures on charophytes: The roles of plasticity and local adaptation
2018
Global change effects, such as warming and increases in nitrogen loading, alter vulnerable Mediterranean aquatic systems, and charophytes can be one of the most affected groups. We addressed the possible interaction between these factors on two populations of the cosmopolitan charophytes Chara hispida and Chara vulgaris. Populations were taken from two different environments, a nitrate-poor mountain lake and a nitrate-rich Mediterranean coastal spring. The laboratory experiment had a 2 × 2 factorial design based on two nitrate levels (similar to and double the local conditions) and two temperatures. Increased temperatures favoured the growth of the four populations, but an increase in nitra…
A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer®), a new intravenous iron preparation and its clinical impli…
2011
Abstract The treatment of iron deficiency anemia with polynuclear iron formulations is an established therapy in patients with chronic kidney disease but also in other disease areas like gastroenterology, cardiology, oncology, pre/post operatively and obstetrics’ and gynecology. Parenteral iron formulations represent colloidal systems in the lower nanometer size range which have traditionally been shown to consist of an iron core surrounded by a carbohydrate shell. In this publication, we for the first time describe the novel matrix structure of iron isomaltoside 1000 which differs from the traditional picture of an iron core surrounded by a carbohydrate. Despite some structural similaritie…
Junceosides A-C, new triterpene saponins from Arenaria juncea.
2002
Three novel triterpenoid saponins, junceosides A (1), B (2), and C (3), together with two known saponins have been isolated from the roots of Arenaria juncea. Their structures were elucidated using a combination of homo- and heteronuclear 2D NMR techniques (COSY, TOCSY, NOESY, HSQC, and HMBC) and by FABMS. The new compounds were characterized as 3-O-alpha-L-arabinopyranosyl-(1-->2)-[beta-D-galactopyranosyl-(1-->3)]-beta-D-glucuronopyranosylgypsogenin-28-O-beta-D-glucopyranosyl(1-->3)-[beta-D-xylopyranosyl-(1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-fucopyranoside (1), 3-O-alpha-L-arabinopyranosyl-(1-->2)-[beta-D-galactopyranosyl-(1-->3)]-beta-D-glucuronopyranosylgypsogenin-28-O-beta-D-x…
Investigation of water transfer across thin layer biopolymer films by infrared spectroscopy
2011
International audience; The investigation of the apparent diffusivity of water in thin layer iota-carrageenan-based films by FTIR-ATR spectroscopy clearly evidences the fundamental role of surface properties on water transfer. Water diffusivity in iota-carrageenan based biopolymer films ranges from 0.3 to 1.3 × 10−10 m2 s−1 and is thus 10–100 times lower than that in highly hydrated carrageenan gels. The surface heterogeneity and composition when fat is added strongly influence the diffusivity by modifying the liquid water absorption at the inner surface.This study of diffusing molecules in liquid state is particularly interesting to mimic situations where direct liquid water contact occurs…
Using ATR-FTIR Spectroscopy To Design Active Antimicrobial Food Packaging Structures Based on High Molecular Weight Chitosan Polysaccharide
2007
ATR-FTIR spectroscopy has been used in this study to characterize the molecular mechanisms and kinetic processes that take place when a chitosonium acetate thin coating is put in contact with water solutions, Staphylococcus aureus solutions, microbial nutrient solutions, and with a high water activity TSA hydrogel medium to simulate the effect of direct contact with high moisture foods such as fresh meats, fish, and seafood products or beverages. The results of this work suggest that the biocide carboxylate groups that form when chitosan is cast from acetic acid solutions are being continuously evaporated from the formed film in the form of acetic acid (mechanism I) in the presence of envir…
Modulation of the growth and metabolic response of cyanobacteria by the multifaceted activity of naringenin
2017
The interactions between the plant-derived bioflavonoid, naringenin, and prokaryotic microalgae representatives (cyanobacteria), were investigated with respect to its influence on the growth and metabolic response of these microorganisms. To achieve reliable results, the growth of cyanobacteria was determined based on measurements of chlorophyll content, morphological changes were assessed through microscopic observations, and the chemical response of cells was determined using liquid and gas chromatography (HPLC; GC-FID). The results show that micromolar levels of naringenin stimulated the growth of cyanobacteria. Increased growth was observed for halophilic strains at naringenin concentra…