Search results for "Array"
showing 10 items of 1264 documents
Transcriptómica de la infertilidad masculina
2012
La infertilidad es un problema cada vez más presente en la sociedad actual, especialmente por razones sociales como por ejemplo la postergación de la maternidad por parte de las parejas y en Europa se calcula que afecta alrededor de a 15% de parejas en edad reproductiva. Las causas de la infertilidad son muchas y pueden afectar a uno sólo de los miembros o a ambos, además su etiología es diversa y a veces es desconocida. Las técnicas de reproducción asistida nacieron como consecuencia de estos problemas acuciantes y desde sus inicios han ido mejorando e innovando para mejorar cada vez más sus tasas de éxito. El mayor éxito en estas técnicas radica en la investigación de los factores que int…
Live demonstration: multiplexing AER asynchronous channels over LVDS Links with Flow-Control and Clock-Correction for Scalable Neuromorphic Systems
2017
Paper presented at the 2017 IEEE International Symposium on Circuits and Systems (ISCAS), held in Baltimore, MD, USA, on 28-31 May 2017.
Measurement of the cosmic ray energy spectrum with IceTop-73
2013
Physical review / D 88(4), 042004 (2013). doi:10.1103/PhysRevD.88.042004
Ultrasonic phased array inspection of wire plus arc additive manufacture samples using conventional and total focusing method imaging approaches
2019
In this study, three aluminium samples produced by wire + arc additive manufacture (WAAM) are inspected using ultrasonic phased array technology. Artificial defects are machined using a centre drill, ø 3 mm, and electrical discharge machining (EDM), ø 0.5-1 mm, in a cylindrical through-hole topology. The samples are first inspected using a single-element wheel probe mounted on a KUKA robot in order to investigate the feasibility of using a conventional ultrasonic transducer approach. Unfortunately, the wheel probe is found to be unsuitable for scanning the WAAM specimens and ultrasonic phased arrays are employed next. The set-up includes 5 MHz and 10 MHz arrays (128 elements) in direct cont…
Key Contributions to the Cross Section of NAND Flash Memories Irradiated With Heavy Ions
2008
Heavy-ion irradiation of NAND flash memories under operating conditions leads to errors with complex, data-dependent signatures. We present upsets due to hits in the floating gate array and in the peripheral circuitry, discussing their peculiarities in terms of pattern dependence and annealing. We also illustrate single event functional interruptions, which lead to errors during erase and program operations. To account for all the phenomena we observe during and after irradiation, we propose an ldquoeffective cross section,rdquo which takes into account the array and peripheral circuitry contributions to the SEU sensitivity, as well as the operating conditions.
Predictive and Prognostic Molecular Factors in Diffuse Large B-Cell Lymphomas.
2021
Diffuse large B-cell lymphoma (DLBCL) is the commonest form of lymphoid malignancy, with a prevalence of about 40% worldwide. Its classification encompasses a common form, also termed as “not otherwise specified” (NOS), and a series of variants, which are rare and at least in part related to viral agents. Over the last two decades, DLBCL-NOS, which accounts for more than 80% of the neoplasms included in the DLBCL chapter, has been the object of an increasing number of molecular studies which have led to the identification of prognostic/predictive factors that are increasingly entering daily practice. In this review, the main achievements obtained by gene expression profiling (with respect t…
Comparison of RNA-seq and microarray-based models for clinical endpoint prediction
2015
Background Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations of microarrays, we sought to systematically evaluate the performance of RNA-seq-based and microarray-based classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a model. Results We generate gene expression profiles from 498 primary neuroblastomas using both RNA-seq and 44 k microarrays. Characterization of the neuroblastoma transcriptome by RNA-seq reveals that more than 48,000 genes and 200,000 transcripts are being …
Profound Transcriptomic Differences Found between Sperm Samples from Sperm Donors vs. Patients Undergoing Assisted Reproduction Techniques Tends to D…
2010
Background Although spermatozoa delivers its RNA to oocytes at fertilization, its biological role is not well characterized. Our purpose was to identify the genes differentially and exclusively expressed in sperm samples both before and after the swim-up process in control donors and infertile males with the purpose to identify their functional significance in male fertility. Materials and methods This was a nested case-control study. Ten sperm samples were obtained from infertile patients [n=5 (two aliquots each from five samples; one before the swim-up process and one after)] and donors [n=5 (two aliquots from five samples, one before the swim-up process and one after)]. Oligonucleotide m…
PVAmpliconFinder: a workflow for the identification of human papillomaviruses from high-throughput amplicon sequencing
2019
Abstract Background The detection of known human papillomaviruses (PVs) from targeted wet-lab approaches has traditionally used PCR-based methods coupled with Sanger sequencing. With the introduction of next-generation sequencing (NGS), these approaches can be revisited to integrate the sequencing power of NGS. Although computational tools have been developed for metagenomic approaches to search for known or novel viruses in NGS data, no appropriate tool is available for the classification and identification of novel viral sequences from data produced by amplicon-based methods. Results We have developed PVAmpliconFinder, a data analysis workflow designed to rapidly identify and classify kno…
A 588-gene microarray analysis of the peripheral blood mononuclear cells of spondyloarthropathy patients
2002
OBJECTIVES: To identify genes which are more highly expressed in the peripheral blood mononuclear cells (PBMC) of patients with spondyloarthropathy (SpA), rheumatoid arthritis (RA) and psoriatic arthritis (PsA), in comparison to normal subjects. METHODS: A 588-gene microarray was used as a screening tool to select a panel of such genes from PBMC of these subjects and of normal subjects. Results were then validated by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: The following genes were more highly expressed in arthritis patients than in normal subjects: macrophage differentiation marker MNDA (myeloid nuclear differentiation antigen), MRP8 and MRP14 (migratory inhibitor…