Search results for "Artemisinins"

showing 5 items of 45 documents

Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells

2010

A novel approach to circumvent multidrug resistance is hybridization of natural products in dimers. We analyzed homodimers of two artesunic acid molecules and heterohybrids of artesunic acid and betulin in human CCRF-CEM and multidrug-resistant P-glycoprotein-overexpressing CEM/ADR5000 leukemia cells. Multidrug-resistant cells were not cross-resistant to the novel compounds. Collateral sensitivity was observed for artesunic acid homodimer. Artesunic acid and artesunic acid homodimer induced G0/G1 cell cycle arrest, apoptosis, and formation of reactive oxygen species.

Spectrometry Mass Electrospray IonizationMagnetic Resonance SpectroscopyCell SurvivalApoptosischemistry.chemical_compoundCell Line TumorDrug DiscoverymedicineHumansCytotoxicitychemistry.chemical_classificationReactive oxygen speciesFormazansLeukemiaBetulinCell CycleSuccinatesCell cycleFlow Cytometrymedicine.diseaseArtemisininsTriterpenesMultiple drug resistanceLeukemiachemistryBiochemistryDrug Resistance NeoplasmCell cultureApoptosisMolecular MedicineReactive Oxygen SpeciesJournal of Medicinal Chemistry
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Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent a…

2010

Artemisia annua L. (sweet wormwood, qinhao) has traditionally been used in Chinese medicine. The isolation of artemisinin from Artemisia annua and its worldwide accepted application in malaria therapy is one of the showcase success stories of phytomedicine during the past decades. Artemisinin-type compounds are also active towards other protozoal or viral diseases as well as cancer cells in vitro and in vivo. Nowadays, Artemisia annua tea is used as a self-reliant treatment in developing countries. The unsupervised use of Artemisia annua tea has been criticized to foster the development of artemisinin resistance in malaria and cancer due to insufficient artemisinin amounts in the plant as c…

Trypanosoma brucei bruceiArtemisia annuaPharmaceutical ScienceArtemisia annuaPharmacologyHeLachemistry.chemical_compoundPhytomedicineParasitic Sensitivity TestsScopoletinparasitic diseasesDrug DiscoverymedicineHumansArtemisininOligonucleotide Array Sequence AnalysisPharmacologyScopoletinEucalyptolDose-Response Relationship DrugMolecular StructurebiologyPlant Extractsfood and beveragesCyclohexanolsbiology.organism_classificationAntineoplastic Agents PhytogenicTrypanocidal AgentsArtemisininsBioactive compoundEucalyptolComplementary and alternative medicinechemistryDrug Resistance NeoplasmCancer cellMonoterpenesMolecular MedicineDrug Screening Assays AntitumorHeLa Cellsmedicine.drugPhytomedicine
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<strong>Artemisinin: Tentative Mechanism of Action and Resistance</strong>

2016

The sesquiterpene lactones constitute a large class of secondary plant metabolites, which carry a‑methylene‑g‑lactone groups as common structural element and display a number of bioactivities. Every year, 1–2 million people living in the tropics and subtropics die of malaria. Lactone artemisinin is the most effective treatment vs. malaria, the most infectious disease in the world today. Artemisinins are derived from extracts of sweet wormwood (Artemisia annua) and are well established for the treatment of malaria, e.g., highly drug-resistant strains. They resulted in one of the most significant advances in the treatment of malaria since the discovery and first use of quinine over 300 years …

chemistry.chemical_classificationArtemisininsQuinineNatural productTraditional medicineArtemisia annuaBiologySesquiterpene lactonemedicine.diseasebiology.organism_classificationchemistry.chemical_compoundDrug developmentchemistryparasitic diseasesmedicineArtemisininMalariamedicine.drugProceedings of 2nd International Electronic Conference on Medicinal Chemistry
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A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the …

2013

Kast, Richard E. et al.

medicine.medical_specialtyCaptoprilTel avivMorpholinesArtesunateReviewGluconatesAngiotensinQuality of lifeAuranofinSertralineAntineoplastic Combined Chemotherapy ProtocolsDisulfiramTemozolomidemedicineRecurrent diseaseHumansIn patientNelfinavirTemozolomideBrain Neoplasmsbusiness.industrySuccinatesNeurokininCytotoxic chemotherapyUniversity hospitalmedicine.diseaseArtemisininsSurgeryDacarbazineKetoconazoleOncologyangiotensin aprepitant artesunate auranofin captopril cytokines disulfiram glioblastoma ketoconazole nelfinavir neurokinin sertraline temozolomideFamily medicineCytokinesNeoplasm Recurrence LocalGlioblastomabusinessAprepitantGlioblastomamedicine.drugOncotarget
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Cytotoxicity of natural products and derivatives toward MCF-7 cell monolayers and cancer stem-like mammospheres

2015

Abstract Although cancer stem-like cells (CSCs) are rare, they can enter a non-proliferative or dormant state and resist therapy. Furthermore, quiescent CSCs are responsible for metastases that can appear after curative surgical treatment of a primary tumor. Because of drug resistance of CSCs, the development of novel therapies is urgently required that specifically target CSCs. Purpose The aim of the present study was to investigate the potential of a panel of natural products and derivatives to inhibit CSC-enriched mammospheres of MCF-7 breast cancer cells. Methods CD44high/CD24low cells were identified by flow cytometry and maintained as mammospheres. As a control, we used two clinically…

medicine.medical_treatmentPhytochemicalsCellArtesunatePharmaceutical ScienceAntineoplastic AgentsBiologyPharmacologyFlow cytometrySpheroids CellularStilbenesDrug DiscoverymedicineHumansCytotoxicityPharmacologyChemotherapymedicine.diagnostic_testCancermedicine.diseasePrimary tumorArtemisininsSalicylatesmedicine.anatomical_structureComplementary and alternative medicineDocetaxelMCF-7MCF-7 CellsNeoplastic Stem CellsMolecular MedicineNaphthoquinonesmedicine.drugPhytomedicine
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