Search results for "Article"

¿Cómo escribir un artículo científico desde la intervención social?

2014

El presente documento pretende ser una guía útil para las y los profesionales de la práctica social. Tiene como objetivo facilitar la redacción de artículos científicos en los que se plasmen las intervenciones sociales realizadas. Estas intervenciones, individuales, grupales o comunitarias son cimientos fundamentales para nuestra disciplina y elemento definitorio de la misma. Desde la Revista TSnova se detectó la dificultad de las y los profesionales para redactar este tipo de manuscritos y, en consecuencia se optó por elaborar un material de ágil consulta. Este es el fruto de ese trabajo en el que aparte de esquematizar los posibles elementos que han de componer un artículo científico, se …

Contribution to thermal behaviour study of lithium-ion battery for electric and hybrid electric vehicle

2014

The main objectives of this study are to provide the essential information on the thermal behaviour of the battery cells for automotive purpose especially for EVs and HEVs through experimental work in order to develop an effective 3D electro-thermal model for lithium ion battery cells and pack. The experimental study is focusing on the distribution of temperature at various points of the battery cell surface, impact of different constant discharge rates, and also the importance of cooling system on the battery temperature behaviour. This thesis highlights the battery cell temperature under abuse discharge condition and the impact of stacking the battery cells inside the battery pack. Impact…

Obesity and survival in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathological subtypes: a pooled…

2013

Obesity is an unfavorable prognostic factor in breast cancer (BC) patients regardless of menopausal status and treatment received. However, the association between obesity and survival outcome by pathological subtype requires further clarification. METHODS: We performed a retrospective analysis including 5,683 operable BC patients enrolled in four randomized clinical trials (GEICAM/9906, GEICAM/9805, GEICAM/2003-02, and BCIRG 001) evaluating anthracyclines and taxanes as adjuvant treatments. Our primary aim was to assess the prognostic effect of body mass index (BMI) on disease recurrence, breast cancer mortality (BCM), and overall mortality (OM). A secondary aim was to detect differences o…

EVALUATION OF BIODEGRADABILITY ON POLYSPARTAMIDE-POLYLACTIC ACID BASED NANOPARTICLES BY CHEMICAL HYDROLYSIS STUDIES POLYMER DEGRADATION AND STABILITY

2015

Here, the synthesis of two graft copolymers based on α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and poly(lactic acid) (PLA), the O-(2-aminoethyl)-O′-galactosyl polyethylene glycol (GAL-PEG-NH2) or the methoxypolyethylene glycol amine (H2N-PEG-OCH3) is described. Starting from the obtained PHEA-PLA-PEG-GAL and PHEA-PLA-PEG copolymers, polymeric nanoparticles were prepared by high pressure homogenization–solvent evaporation method. To demonstrate their biodegradability as a function of the matrix composition, a chemical stability study was carried out until 21 days by incubating systems in two media mimicking physiological compartments (pH 7.4 and pH 5.5). The degradability of both nan…

Evaluation of biodegradability of novel polymeric nanoparticles based on amphiphilic polylactide-polyaspartamide derivatives.

2015

Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

2021

The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidative stress) states. This PTM typically maps at multiple protein sites, generating a heterogeneous population of proteoforms with specific biophysical and biochemical properties. The identification and quantitation of the variety of oxidized proteoforms originated under a given condition is required to assess the exact molecular nature of the species responsible for the process under investigation…

High-precision measurement of a low Q value for allowed β−-decay of 131I related to neutrino mass determination

2022

The ground-state-to-ground-state β−-decay 131I (7/2+) → 131Xe (3/2+) Q value was determined with high precision utilizing the double Penning trap mass spectrometer JYFLTRAP at the IGISOL facility. The Q value of this β−-decay was found to be Q = 972.25(19) keV through a cyclotron frequency ratio measurement with a relative precision of 1.6 × 10−9. This was realized using the phase-imaging ion-cyclotron-resonance technique. The new Q value is more than 3 times more precise and 2.3σ higher (1.45 keV) than the value extracted from the Atomic Mass Evaluation 2020. Our measurement confirms that the β−-decay to the 9/2+ excited state at 971.22(13) keV in 131Xe is energetically allowed with a Q va…

Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ‐Lactams

2021

Abstract Asymmetric access to γ‐lactams is achieved via a cyclobutanone ring expansion using widely available (1S,2R)‐1‐amino‐2‐indanol for chiral induction. Mechanistic analysis of the key N,O‐ketal rearrangement reveals a Curtin–Hammett scenario, which enables a downstream stereoinduction (up to 88:12 dr) and is corroborated by spectroscopic, crystallographic, and computational studies. In combination with an easy deprotection protocol, this operationally simple sequence allows the synthesis of a range of optically pure γ‐lactams, including those bearing all‐carbon quaternary stereocenters. In addition, the formal synthesis of drug molecules baclofen, brivaracetam, and pregabalin further …

Evidence against the wobbling nature of low-spin bands in 135Pr

2021

International audience; The electromagnetic character of the ΔI=1 transitions connecting the 1- to 0-phonon and the 2- to 1-phonon wobbling bands should be dominated by an E2 component, due to the collective motion of the entire nuclear charge. In the present work it is shown, based on combined angular correlation and linear polarization measurements, that the mixing ratios of all analyzed connecting transitions between low-lying bands in 135Pr interpreted as 0-, 1-, and 2-phonon wobbling bands, have absolute values smaller than one. This indicates predominant M1 magnetic character, which is incompatible with the proposed wobbling nature. All experimental observables are instead in good agr…

The Use of Stable Isotope Ratio Analysis to Trace European Sea Bass (D. labrax) Originating from Different Farming Systems

2020

This study aimed to determine whether isotopic ratio mass spectrometry (IRMS) can discriminate farmed European sea bass according to different farming systems and geographic origins. Dicentrarchus labrax of commercial size from three different rearing systems (concrete tank inland, sea cages, and extensive methods in valleys or salt works) were collected at the trading period (autumn&ndash