Search results for "Ascription"

showing 10 items of 13 documents

Transcriptional Profiles and Stromal Changes Reveal Bone Marrow Adaptation to Early Breast Cancer in Association with Deregulated Circulating microRN…

2020

Abstract The presence of a growing tumor establishes a chronic state of inflammation that acts locally and systemically. Bone marrow responds to stress signals by expanding myeloid cells endowed with immunosuppressive functions, further fostering tumor growth and dissemination. How early in transformation the cross-talk with the bone marrow begins and becomes detectable in blood is unknown. Here, gene expression profiling of the bone marrow along disease progression in a spontaneous model of mammary carcinogenesis demonstrates that transcriptional modifications in the hematopoietic compartment occurred as early as preinvasive disease stages. The transcriptional profile showed downregulation…

0301 basic medicineCancer ResearchMyeloidStromal cellInflammationApoptosisBreast NeoplasmsBiologySettore MED/08 - Anatomia PatologicaCXCR403 medical and health sciencesMice0302 clinical medicineBone MarrowmedicineBiomarkers TumorTumor Cells CulturedAnimalsHumansCirculating MicroRNACell ProliferationMice Inbred BALB CInnate immune systemGene Expression ProfilingAcquired immune systemAdaptation PhysiologicalXenograft Model Antitumor AssaysGene Expression Regulation NeoplasticHaematopoiesis030104 developmental biologymedicine.anatomical_structureOncologyTrascriptional profiles early brest cancer microRNAs030220 oncology & carcinogenesisCancer researchFemaleBone marrowmedicine.symptomStromal CellsTranscriptomeCancer research
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How Hand Gestures Contribute to Action Ascription

2019

ABSTRACTThis article investigates the embodied achievement of intersubjectivity by analyzing depictive gestures that are produced during the final components of the ongoing verbal TCU and extended ...

050101 languages & linguisticsLinguistics and LanguageCommunicationSocial Psychologybusiness.industryCommunication05 social sciences050105 experimental psychologyAscriptionAction (philosophy)Embodied cognition0501 psychology and cognitive sciencesbusinessPsychologyIntersubjectivityGestureResearch on Language and Social Interaction
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Discordances in Ascriptions of Agency and Reflectivity in the First Psychotherapy Session

2018

We analyzed the first sessions of nine long-term individual psychotherapies with a model of ten discursive tools of agency ascription and studied discursive discordances, sequences of two talk turns in which the therapeutic dyad was misaligned in terms of how they ascribed agency to the client. We also studied how the clients’ agency self-ascriptions in the turn immediately following the discordances changed from the first turn. Classifying these discordance sequences, eight different types of sequences were found. One, in which the clients’ reflective agency constructions were missed by the therapists, was subjected to a detailed analysis. peerReviewed

050103 clinical psychologyLinguistics and LanguageSocial Psychology05 social sciences050109 social psychologylong-term individual psychotherapiestoimijuusfirst sessionspsykoterapiaReflectivityAscriptionAgency (sociology)Developmental and Educational Psychology0501 psychology and cognitive sciencesSession (computer science)PsychologySocial psychologydiscursive toolsreflektio
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The internationality imperative in academia. The ascent of internationality as an academic virtue

2017

ABSTRACTThe paper investigates internationality as an academic virtue that is highly relevant for research biographies. The discursive trajectory of this virtue is assessed by comparing ascriptions of internationality in 216 academic obituaries from the US, UK and Germany, from physics, sociology and history, and from the 1960s, 1980s and 2000s. Our analysis reveals that internationality as a virtue is more prevalent in German than in US obituaries, that it plays a greater role in physics than in history obituaries, and that, independent from national and disciplinary contexts, the ascription of internationality increases over time. The results are relevant for research on academic values a…

050402 sociologyVirtueHigher educationbusiness.industrymedia_common.quotation_subjectDiscourse analysis05 social sciences050301 educationEducationEpistemologyInternationalizationEducational researchAscription0504 sociologySociologyComparative educationbusiness0503 educationDisciplinemedia_commonHigher Education Research & Development
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Spanish Version of the Time Management Behavior Questionnaire for University Students

2012

The main objective of the study is to analyze the psychometric properties and predictive capacity on academic performance in university contexts of a Spanish adaptation of the Time Management Behavior Questionnaire. The scale was applied to 462 students newly admitted at the Universitat de València in the 2006-2007 school year. The analyses performed made it possible to reproduce the factorial structure of the original version of the questionnaire with slight modifications in the ascription of various ítems. The underlying factorial structure includes four interrelated dimensions (Establishing objectives and priorities, Time management tools, Perception of time control and Preference for di…

AdultMaleLinguistics and LanguageTime FactorsPsychometricsUniversitiesApplied psychologyLanguage and LinguisticsYoung AdultAscriptionSurveys and QuestionnairesMultiple time dimensionsHumansTime managementStudentsSelf-regulated learningGeneral PsychologyReliability (statistics)Reproducibility of ResultsTime ManagementConvergent validitySpainScale (social sciences)WorkforceWorkforceFemalePsychologySocial psychologyThe Spanish journal of psychology
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Identification of a putative regulator of early-histone gene expression of Paracentrotus lividus

2016

Drosophila GAGA factor (GAF) is a nuclear protein, conserved along evolution, with multiple roles in gene regulation, chromatin remodelling, Polycomb-dependent silencing, and insulator functions (1). GAF recognizes and specifically binds GAGAG consensus DNA motif by its C2H2-type zinc-finger domain, and interacts with other regulatory factors by its BTB/POZ domain. We have identified plGaga, a cDNA coding for a putative GAF of the sea urchin P. lividus, which showed significant sequence similarity with Drosophila and vertebrate GAFs. Real time RT-PCR revealed that the plGaga RNA is always present during embryo development decreasing rapidly in abundance at the larval pluteus stage. We raise…

GAGA factor trascriptional regulation
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Cognitive status and referential acts in functional discourse grammar

2018

In Functional Discourse Grammar, both Ascription and Reference are characterized as actional processes and are captured at the Interpersonal Level of linguistic description. Additionally, the temporal sequencing of Discourse Acts seems relevant to establishing dependency relations among them. However, the remainder of the levels of representation in the theory contain static descriptions of linguistic structures and not of processes. In this paper, I will argue that this is the result of an inherent contradiction between FDG’s characterization as a static grammar and the dynamicity of verbal interaction, which is best solved if the theory commits itself to the procedural nature of the Inter…

Linguistics and LanguageGrammarmedia_common.quotation_subjectFunctional discourse grammarRepresentation (arts)Interpersonal communicationReferentLanguage and LinguisticsLinguisticsAscriptionContradictionLinguistic descriptionPsychologymedia_commonQuaderns de Filologia - Estudis Lingüístics
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Handling knowledge: Using classroom materials to construct and interpret information requests

2015

Abstract This article contributes to the recent conversation analytic interest in exploring the mechanisms of action formation and ascription by investigating how embodied interactional practices involving material objects relate to the organization of social action. Using as data information request sequences in student–student interaction, the study highlights the material nature of an interactional context and examines how students orient in talk and by bodily-visual means to their and their co-conversants’ textual documents during individual task work. Sequential analyses illustrate how the manual handling of such everyday learning materials as handouts and tasks sheets is not only an i…

Linguistics and Languagemedia_common.quotation_subjectta6121Context (language use)Language and LinguisticsMultimodalitySocial actionsAscriptionArtificial Intelligenceta516Conversationlearning materialsmultimodalitysocial epistemicsmedia_common060201 languages & linguisticsCognitive science4. Education05 social sciences050301 education06 humanities and the artsAction (philosophy)Embodied cognitionaction formation0602 languages and literatureclassroom interactionobjects in interactionConstruct (philosophy)Psychology0503 educationSocial psychologyJournal of Pragmatics
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Kā robežas ietekmē NATO ģimenes locekļu integrāciju uzņēmējvalstī

2020

Bakalaura darbā es koncentrējos gan uz fiziskajām, gan abstraktajām NATO robežām, kas ir ietekmējošie faktori NATO ģimeņu integrācijas procesā uzņemšanas valstī un organizācijas dalībnieku identitātes veidošanā. Es skatu kā abstraktās robežas, piemēram, valodas robežas, tiek konstruētas un uzturētas militārajā kontekstā. Analizējot dalībnieku intervijas, es uzsveru cilvēku pieredzes aspektus gan NATO robežās, gan ārpus tām, dalībnieku pašidentifikāciju, kā arī kultūru apvienošanos.

NATOAntropoloģijaStructural BordersIntangible BordersTransculturalizationSelf-Ascription and Identity
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The southernmost Miocene occurrence of the last European herpetotheriid Amphiperatherium frequens (Metatheria, Mammalia)

2012

Abstract The present work provides for the first time a detailed description of teeth attributable to metatherians in the Miocene fossil record of Spain, and justifies their generic and specific ascription. The fossil elements found correspond to Amphiperatherium frequens, the last herpetotheriid that inhabited Europe. This is so far the southernmost occurrence of this species, thus showing that its geographic range extended further southward than previously thought.

PaleontologyAscriptionFossil RecordbiologyHerpetotheriidaeGeneral EngineeringMetatheriaNeogenebiology.organism_classificationGeologyComptes Rendus Palevol
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