Search results for "Association."
showing 10 items of 1723 documents
Cross-Frequency Coupling in Developmental Perspective
2019
It is generally assumed that different electroencephalogram (EEG) frequency bands are somehow related to different computational modes in the brain. Integration of these computational modes is reflected in the phenomenon of cross-frequency coupling (CFC). On slow temporal scales, CFC may reflect trait-like properties, which posits a question of its developmental trends. This is the first study that explored source-level CFC measures in a developmental perspective using both cross-sectional and longitudinal designs. CFC measures demonstrated good test-retest stability and proved to be higher in adults in cortical areas participating in sensory-motor integration, response inhibition, and atte…
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
2023
Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on t…
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary …
2023
Funder: British Lung Foundation (BLF); doi: https://doi.org/10.13039/501100000351
Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms
2010
Background— Cholesteryl ester transfer protein (CETP) inhibitors raise high-density lipoprotein (HDL) cholesterol, but torcetrapib, the first-in-class inhibitor tested in a large outcome trial, caused an unexpected blood pressure elevation and increased cardiovascular events. Whether the hypertensive effect resulted from CETP inhibition or an off-target action of torcetrapib has been debated. We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target. Methods and Results— We compared the effect of CETP single-nucleotide polymorphisms …
Biotic homogenisation in bird communities leads to large-scale changes in species associations
2020
AbstractAimThe impact of global change on biodiversity is commonly assessed in terms of changes in species distributions, community richness and community composition. Whether and how much associations between species, i.e. the degree of correlation in their spatial co-occurrence, are also changing is much less documented and mostly limited to local studies of ecological networks. In this study, we quantify changes in large-scale patterns of species associations in bird communities in relation to changes in species composition.LocationFrance.Time period2001-2017.Major taxa studiedCommon breeding birds.MethodsWe use network approaches to build three community-aggregated indices reflecting co…
Reasoned and implicit processes in heavy episodic drinking : An integrated dual‐process model
2020
Objectives: University students commonly engage in heavy episodic drinking (HED), which contributes to injury risk, deleterious educational outcomes, and economic costs. Identification of the determinants of this risky behaviour may provide formative evidence on which to base effective interventions to curb HED in this population. Drawing from theories of social cognition and dual‐process models, this study tested key hypotheses relating to reasoned and implicit pathways to action for HED in a sample of Australian university students who drink alcohol. Design: A two‐wave correlational design was adopted. Methods: Students (N = 204) completed self‐reported constructs from social cognition th…
Reciprocal relations between past behavior, implicit beliefs, and habits : A cross-lagged panel design
2023
The current study assessed cross-lagged relationships between binge drinking, implicit beliefs, and habit in undergraduate university students ( N = 105). Students completed self-report survey and implicit measures in lab visits 3 months apart. A structural equation model revealed cross-lagged relations between habit and behavior, and some evidence for a reciprocal relationship between implicit beliefs and habit. Implicit beliefs were related to alcohol behavior across time, but no cross-lagged relationship was observed. Findings provide preliminary support for recent advances in habit theory, suggesting that implicit beliefs and habit may develop in tandem or even share common knowledge s…
MOTIVATION – A STIMULATING FACTOR FOR INCREASING HUMAN RESOURCE MANAGEMENT PERFORMANCE
2012
Motivation is the basis of behaviours and activities that people deliver inside the association in relation to the peculiarity of the challenges that follow a category or another of functional relations. Thus, in order to assure the performance of the modern associations there is the need to know and understand the elements that motivate or demotivate an employee and even more, to apply them. Individual and constructional performance is in direct relationship with the direct implementation of the management of human resources. Thus, only by knowing the motivational theories and by applying efficient managerial strategies in order to engage the employees in competitive achievement of the org…
Transformacja Polskiego Związku Łowieckiego w świetle ewolucji modelu łowiectwa w Polsce
2020
The Polish Hunting Association is a nationwide organization of Polish hunters and hunting clubs, whose traditions date back to the interwar period. This study presents the genesis and evolution of the Polish Hunting Association, which, in the wake of social and political changes in the country, has been transformed from a voluntary association into a monopolistic and compulsory-membership organization, which is to carry out tasks commissioned by public authorities. Additionally, as a result of further amendments, the Association has been transformed into a governmental agency, organizationally subordinated to the minister of the environment also in the scope of appointing its high-rank staf…
Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease.
2022
Background & Aims: Obesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of macrophage scavenger receptor 1 (MSR1, CD204) remains incompletely understood. Methods: A total of 170 NAFLD liver biopsies were processed for transcriptomic analysis and correlated with clinicopathological features. Msr1(-/-) and wild-type mice were subjected to a 16-week high-fat and high-cholesterol diet. Mice and ex vivo human liver slices were treated with a monoclonal antibody against MSR1. Genetic susceptibility was assessed using genome-wide association study data from 1,483 patients with NAFLD and 430,101 participants of the U…