Search results for "Atg1"

showing 2 items of 12 documents

ATG16L1 contribution to Crohnʼs disease risk in Sicily

2011

medicine.medical_specialtyCrohn's diseaseSettore MED/09 - Medicina InternaPolymorphism Geneticbusiness.industryGastroenterologyAutophagy-Related Proteinsmedicine.diseaseGastroenterologyCrohn DiseaseRisk FactorsInternal medicinemedicineHumansImmunology and AllergyCarrier ProteinsbusinessCrohn's disease.genetics.ATG16L1SicilyATG16L1Inflammatory Bowel Diseases
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Rab33B and its autophagic Atg5/12/16L1 effector assist in hepatitis B virus naked capsid formation and release

2015

Hepatitis B virus morphogenesis is accompanied by the production and release of non-enveloped capsids/nucleocapsids. Capsid particles are formed inside the cell cytosol by multimerization of core protein subunits and ultimately exported in an uncommon coatless state. Here, we investigated potential roles of Rab GTPases in capsid formation and trafficking by using RNA interference and overexpression studies. Naked capsid release does not require functions of the endosome-associated Rab5, Rab7 and Rab27 proteins, but depends on functional Rab33B, a GTPase participating in autophagosome formation via interaction with the Atg5-Atg12/Atg16L1 complex. During capsid formation, Rab33B acts in conju…

virusesATG8ImmunologyATG5Autophagybiochemical phenomena metabolism and nutritionBiologyGroup-specific antigenMicrobiologyVirus ReleaseCell biologyATG12CapsidVirologyRabCellular Microbiology
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