Search results for "Atopic"
showing 10 items of 100 documents
Cyanocobalamin Ultraflexible Lipid Vesicles: Characterization and In Vitro Evaluation of Drug-Skin Depth Profiles
2021
Atopic dermatitis (AD) and psoriasis are the most common chronic inflammatory skin disorders, which importantly affect the quality of life of patients who suffer them. Among other causes, nitric oxide has been reported as part of the triggering factors in the pathogenesis of both conditions. Cyanocobalamin (vitamin B12) has shown efficacy as a nitric oxide scavenger and some clinical trials have given positive outcomes in its use for treating skin pathologies. Passive skin diffusion is possible only for drugs with low molecular weights and intermediate lipophilicity. Unfortunately, the molecular weight and hydrophilicity of vitamin B12 do not predict its effective diffusion through the skin…
Patients Withdrawing Dupilumab Monotherapy for COVID-19-Related Reasons Showed Similar Disease Course Compared With Patients Continuing Dupilumab The…
2022
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The Influence of Microbiome Dysbiosis and Bacterial Biofilms on Epidermal Barrier Function in Atopic Dermatitis—An Update
2021
Atopic dermatitis (AD) is a common inflammatory dermatosis affecting up to 30% of children and 10% of adults worldwide. AD is primarily driven by an epidermal barrier defect which triggers immune dysregulation within the skin. According to recent research such phenomena are closely related to the microbial dysbiosis of the skin. There is growing evidence that cutaneous microbiota and bacterial biofilms negatively affect skin barrier function, contributing to the onset and exacerbation of AD. This review summarizes the latest data on the mechanisms leading to microbiome dysbiosis and biofilm formation in AD, and the influence of these phenomena on skin barrier function.
Derechos y deberes. El horizonte de la responsabilidad
2013
El artículo recorre aquellos acontecimientos y textos del siglo XX más reveladores a la hora de abordar la relación entre derechos y deberes, proponiendo una lectura renovada de la noción de responsabilidad humana. La reflexión sobre las carencias del individualismo y del estatalismo, latentes en la cultura jurídicopolítica contemporánea, no pretende relativizar el papel de los derechos sino tratar de reforzarlo a través de un discurso permeable a otras formulaciones de las exigencias de justicia y a otras concepciones del mundo, con el objetivo de fortalecer la conciencia cívica, el tejido social relacional, la asunción responsable de las propias obligaciones y una idea de universalidad má…
Does sensitization through the skin occur?
2000
A different pattern of risk factors for atopic and non-atopic wheezing in 9-12-year-old children
2005
Few epidemiological studies have compared the risk factors of asthma or wheezing between atopic and non-atopic children. The objective of this study was to determine if there are specific risk factors for current wheezing related to atopic status in schoolchildren. Schoolchildren 9-12 yr of age from three Spanish cities (n = 2720) were subject to a cross-sectional study of asthma risk factors (by questionnaire) and atopy (by skin prick test) according to the ISAAC phase-II protocol. Risk factors for current wheezing (in the last 12 months) as reported by parents were investigated among the atopic (positive prick test to at least one allergen) and the non-atopic (negative prick test) childre…
Evaluation of Erythema Severity in Dermatoscopic Images of Canine Skin: Erythema Index Assessment and Image Sampling Reliability.
2021
The regular monitoring of erythema, one of the most important skin lesions in atopic (allergic) dogs, is essential for successful anti-allergic therapy. The smartphone-based dermatoscopy enables a convenient way to acquire quality images of erythematous skin. However, the image sampling to evaluate erythema severity is still done manually, introducing result variability. In this study, we investigated the correlation between the most popular erythema indices (EIs) and dermatologists’ erythema perception, and we measured intra- and inter-rater variability of the currently-used manual image-sampling methods (ISMs). We showed that the EIBRG, based on all three RGB (red, green, and blue) channe…
Selection of erythema index and image sampling method for the objective erythema estimation in dogs with atopic dermatitis
2020
Canine atopic dermatitis (CAD) is a common inflammatory and pruritic skin disease associated with allergy to exogenous allergens. The regular monitoring of skin lesions is essential to execute the anti-allergic therapy successfully. Erythema is one of the most important CAD-related lesions since it represents acute skin inflammation. Previously, we studied two optical systems (i.e., multispectral and dermatoscopic devices), which could objectively estimate erythema severity. However, we did not investigate, which image sampling method for selecting erythema-representing pixels and erythema index (EI) are correlated with the visual erythema assessment the most. In this paper, we tested three…
Vitamin D receptor gene polymorphisms in atopy
2021
Abstract Background The occurrence of allergic conditions, for example allergic asthma, rhinitis, and atopic dermatitis, is rising worldwide. These allergic conditions are associated with poor life quality. Vitamin D is proposed to be linked with increased risk and severe forms of allergic diseases. Aims This review article aimed to evaluate the vitamin D level role and polymorphisms of vitamin D receptor gene (VDR) in atopy. Methods & Materials We analyzed publications that were focusing on levels of vitamin D and/or polymorphism analysis of vitamin D receptor gene in allergic asthma, rhinitis, and atopic dermatitis patients. Results We noticed that levels of vitamin D are extensively stud…