Search results for "Audit"
showing 10 items of 1421 documents
Anatomy and Physiology of the Peripheral and Central Auditory System
2019
The auditory system is responsible for the hearing sense and it consists of the peripheral auditory system (outer, middle and inner ear) and of the central auditory system (vestibular and cochlear nuclei, auditory and vestibular pathways and vestibular and auditory cortices). The outer ear comprises the auricle and the auditory canal and its function is to guide air pressure waves to the middle ear. The middle ear consists of the tympanic membrane, connected to the inner ear by three ossicles (malleus, incus and stapes), which vibrations allow the transmission of originally airborne sound waves to the perilymph of the inner ear. The middle ear provides a pressure gain as well as enhanced qu…
Event-Related Potentials to Changes in Sound Intensity Demonstrate Alterations in Brain Function Related to Depression and Aging
2020
Measures of the brain’s automatic electrophysiological responses to sounds represent a potential tool for identifying age- and depression-related neural markers. However, these markers have rarely been studied related to aging and depression within one study. Here, we investigated auditory event-related potentials (ERPs) in the brain that may show different alterations related to aging and depression. We used an oddball condition employing changes in sound intensity to investigate: (i) sound intensity dependence; (ii) sensory gating; and (iii) change detection, all within a single paradigm. The ERPs of younger (18–40 years) and older (62–80 years) depressed female participants and age-match…
Tema 1. Conceptos básicos de la auditoría sociolaboral
2014
Presentación del Tema 1 de la asignatura Auditoría Sociolaboral
Towards therapeutic gene delivery to human cancer cells : targeting and entry of baculovirus
2008
Geeniterapia on yksi tulevaisuuden hoitomuodoista taistelussa syöpää vastaan. Virukset ovat evoluution myötä kehittyneet tehokkaiksi geeninsiirtäjiksi ja ovat nykyään käytetyimpiä geeninsiirtovektoreita. Yksi geenihoitojen yleistymisen esteistä on kuitenkin ollut virusvektoreiden puutteellinen kohdennus haluttuun kudokseen. Kohdentaminen on erityisen tärkeää syövän hoidossa, jotta hoito vaikuttaisi pääasiassa pahanlaatuisiin soluihin.Mäkelä kehitti tutkimuksessaan syöpäsoluihin kohdentuvia bakulovirusperäisiä geeninsiirtovektoreita. Hän tutki myös viruksen sisäänmenomekanismeja ja kulkeutumista kohdesoluissa.- Hyönteisiä infektoiva bakulovirus on luontaisesti vaaraton ihmisille. Se on helpo…
Comparison of Delivery Methods in Phage Therapy against Flavobacterium columnare Infections in Rainbow Trout
2021
This dataset consists of three phage therapy experiments to prevent Flavobacterium columnare infections in rainbow trout. Experiments I and II were done in stagnant water, and Experiment III in a flow-through system. See the documentation file attached with the dataset for full description of the methods (also found in the original article).
Quantity and Quality of Aquaculture Enrichments Influence Disease Epidemics and Provide Ecological Alternatives to Antibiotics
2021
Environmental heterogeneity is a central component influencing the virulence and epidemiology of infectious diseases. The number and distribution of susceptible hosts determines disease transmission opportunities, shifting the epidemiological threshold between the spread and fadeout of a disease. Similarly, the presence and diversity of other hosts, pathogens and environmental microbes, may inhibit or accelerate an epidemic. This has important applied implications in farming environments, where high numbers of susceptible hosts are maintained in conditions of minimal environmental heterogeneity. We investigated how the quantity and quality of aquaculture enrichments (few vs. many stones
The influence of infective dose, nutrient availability and coinfection on virulence of Flavobacterium columnare : implications of intensive aquacultu…
2016
Ecological factors are known to affect disease dynamics and even lead to disease emergence. Especially in opportunistic, environmentally transmitted pathogens, the environment may significantly contribute to pathogen virulence. Intensive farming, including aquaculture, has been suggested to create conditions favouring development of highly virulent pathogens. At Finnish fish farms, epidemics caused by opportunistic Flavobacterium columnare have been constantly increasing in their prevalence and severity since the 1980’s. Yet, factors behind the increased virulence of the pathogen and their mechanisms of action have largely remained unsolved. In this thesis, I explore the effects of infectio…
Exploring evolutionary responses to increasing temperature in an environmental opportunistic pathogen
2017
Transmission and host and mate location in the fish louse Argulus coregoni and its link with bacterial disease in fish
2007
FM Matthias Bandilla osoittaa väitöstutkimuksessaan, että kirjolohen kalatäitartunnalla on selkeä yhteys Flavobacterium columnare -infektioon, joka on yksi ongelmallisimmista bakteeritaudeista suomalaisessa kalanviljelyssä tällä hetkellä. Vaikka heikko kalatäitartunta ei aiheuta kalan kuolemaa, yhdessä bakteerialtistuksen kanssa se voi olla tappava. Vastaavien vuorovaikutusten ymmärtäminen olisi tärkeää vesiviljelyn kannalta, koska erilaisten mikrobien aiheuttamien tautien ja loisten yhteisesiintyminen kalanviljelylaitoksella on ennemminkin sääntö kuin poikkeus.Kalatäi (Argulus coregoni) on pääasiassa lohikaloilla esiintyvä äyriäispintaloinen, jonka levinneisyys ulottuu koko pohjoiselle vyö…